2021 News Briefs - International Neuromodulation Society

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Researchers Begin Human Trial of Deep Brain Stimulation in Anorexia Nervosa

Dec. 29, 2021 - A 10-person clinical trial has begun in Queensland, Australia, to study deep brain stimulation as a potential treatment for people who have treatment-resistant anorexia nervosa. (Source: ABC)

Author Discusses Disparities in Access to Spinal Cord Stimulation

Dec. 22, 2021 - An article discusses current gaps and barriers in patient access to spinal cord stimulation. (Source: NeuroNews)

Registry-Based Study in Norwegian Epilepsy Patients Assessed Long-Term Vagus Nerve Stimulation Efficacy

Dec. 22, 2021 - A 60-month study evaluated the efficacy of vagus nerve stimulation for epilepsy in adults and children, based on a Norwegian registry. An associated regression analysis sought to identify predictors of response. (Source: DocWire News)

Journal Article Describes Experience with Neurostimulation for Refractory Tourette Syndrome

Dec. 9, 2021 - A team of co-authors report on effects of deep brain stimulation in a man with refractory Tourette syndrome that involved obsessive compulsive symptoms and tics. The authors offer suggestions about targeting pathways and circuits, saying single components may be involved in multiple pathways that are related to different states. (Source: Clinical Case Reports)

Authors Study Noninvasive Brain Stimulation Targeting and Outcomes

Nov. 13, 2021 - A sham-controlled study of patients with post-stroke hemiplegia compared two methods of targeting repetitive transcranial magnetic stimulation, and assessed the feasibility of targeting through functional near-infrared spectroscopy. (Source: Neurology and Therapy)

Article Describes Deep Brain Stimulation Treatment of a Patient with Obsessive Compulsive Disorder

Dec. 21, 2021 - A patient with obsessive compulsive disorder underwent deep brain stimulation in Argentina for the condition. (Source: OI Canadian)

Clinicians Report on Treating Two Long-COVID Patients with Noninvasive Brain Stimulation

Dec. 15, 2021 - Clinicians in Germany report on treatment of two patients who had long-COVID symptoms, and were administered noninvasive alternating current stimulation of the eyes and brain. The authors report on the patients' cognition and visual-field function. (Source: Restorative Neurology and Neuroscience)

Noninvasive Brain Stimulation Study Investigates Decision-Making

January 2022 - Investigators in Europe published results of a placebo-controlled study of the modulating effect of high-definition transcranial direct current stimulation to the temporo-parietal junction on how participants weighed choices about environmental sustainability that might benefit future generations, which the authors said entailed intergenerational mentalizing while engaging in a social dilemma game of the type used in behavioral economics. (Source: Cortex)

Noninvasive Neurostimulator to Be Studied in Stroke Survivors

Dec. 17, 2021 - Helius Medical Technologies Inc. announced a partnership with a researcher at the Medical University of South Carolina to study the effect of the company's cranial-nerve non-invasive neuromodulation system on dynamic balance in chronic stroke survivors. (Source: BioSpace)

Researchers Prepare for a Clinical Trial of a Potential Visual Prosthesis

Dec. 16, 2021 - Researchers in Chicago are seeking clinical trial participants for a study of an intracortical visual prosthesis, set to begin in 2022. (Source: WGN)

Study Reports Effects of Deep Brain Stimulation on Postural Alignment and Adaptation in Parkinson's Disease

Dec. 14, 2021 - Researchers studied alterations in body position of Parkinson's disease patients with deep brain stimulation off or on, and in comparison to young and old control participants. (Source: PLoS One)

Clinicians Investigate Noninvasive Brain Stimulation in Laryngeal Dystonia

Dec. 2, 2021 - Clinicians published a a safety, feasibility, and pilot study of repetitive transcranial magnetic stimulation in adductor laryngeal dystonia, at a frequency that prolongs intracortical inhibition. (Source: Experimental Brain Research)

Advisory Panel Reviews Data about Neurostimulator Trialled After Ischemic Stroke

Dec. 13, 2021 - An FDA advisory panel reviewed clinical trial data submitted by Israel-based BrainsGate concerning its sphenopalatine ganglion stimulation device, which is intended to provide short-term therapy starting 8 - 24 hours after ischemic stroke. (Source: MedTech Dive)

Company Announces $5 Million Equity Investment

Dec. 8, 2021 - NeuroSigma, Inc. announced that the Korea-based digital telecommunications company KT Corporation made a $5 million equity investment in the company, which developed external trigeminal nerve stimulation to treat neurological and neuropsychiatric indications. (Source: Globe Newswire)

Company Announces Patent for Noninvasive Therapy Addressing Acute Stroke Symptoms

Dec. 13, 2021 - The company electroCore, Inc. announced receiving a U.S. patent related to noninvasive electrical stimulation to treat acute symptoms of stroke or transient ischemic attack. (Source: Globe Newswire)

Alternative Electrode Implantation Techniques Reported

Dec. 12, 2021 - Clinicians report, in two cases, on three different alternatives for dorsal root ganglion electrode implantation. (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)

Review Assesses Monotherapy with Baclofen in Severe Spasticity

Dec. 11, 2021 - A team of authors reviewed 20 studies regarding the effects of monotherapy with intrathecal baclofen on pain, function and quality of life in patients with severe spasticity. (Source: Current Pain and Headache Reports)

Authors Report a Retrospective Study of Spinal Cord Stimulation in Neurogenic Claudication

December 2021 - A retrospective study of a prospectively collected database assessed outcomes and efficacy of spinal cord stimulation in neurogenic claudication in patients with, or without, prior surgery for lumbar spinal stenosis. (Source: Pain Physician Journal)

Patient Enrollment Begins in Clinical Trial of Noninvasive Brain Stimulation Following Stroke

Dec. 9, 2021 - BrainQ announced the start of patient enrollment in its pivotal clinical trial of frequency-tuned electromagnetic field treatment in people who recently experienced moderately severe ischemic stroke. The company's wearable stimulation device received FDA breakthrough device designation, announced last week. (Source: PR Newswire)

Researchers Seek Symptom-Severity Biomarkers in Obsessive Compulsive Patients Implanted with Deep Brain Stimulation Systems

Dec. 9, 2021 - A research team reports on seeking candidate biomarkers of symptom intensity through recording of local field potentials in study participants who have obsessive compulsive disorder and were implanted with deep brain stimulation systems capable of making such recordings. (Source: Nature Medicine)

Clinicians to Study Cervical Spinal Cord Stimulation in Patients at Risk of Secondary Stroke

Dec. 8, 2021 - Researchers in Berne, Switzerland are starting a proof-of-concept trial in up to 15 enrollees of cervical spinal cord stimulation to invesstigate its effect on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. The device will be explanted after 15 days, and patients followed for six months. (Source: Trial Bulletin)

University Research Focuses on Wireless Neurostimulators

Dec. 8, 2021 - A television segment features research at Rice University to have two or more wireless neurostimulation implants powered and programmed by a single transcutaneous transmitter. (Source: WQAD)

Researchers Present a Psychological Screening Protocol for Pain Patients Anticipating Neuromodulation Therapy

Dec. 3, 2021 - At a recent scientific meeting, researchers presented a psychological screening protocol that was used to decide which chronic pain patients should proceed to an in-person psychological assessment prior to a neuromodulation trial phase. (Source: NeuroNews)

Device Company Announces $32 Million in Series A Funding

Dec. 2, 2021 - Avivomed Inc. announced a $32 million Series A round of financing for its neuromodulation technology. (Source: Business Journals)

Investigators Publish 2-Year Data from Patients Receiving Restorative Neurostimulation for Chronic Low Back Pain

December 2021 - Investigators have published results from up to two years from a longitudinal cohort of 42 patients with chronic mechanical low back who received restorative neurostimulation therapy. (Source: Pain and Therapy)

$10 Million in Seed Funding Raised by a U.K. Startup Seeking to Commercialize a Noninvasive Stimulation Device for Parkinson's Disease Motor Symptoms

Nov. 24, 2021 - A startup spun out of London's Imperial College, Charco Neurotech, has raised $10 million in seed funding as it pursues commercial development of a noninvasive system to deliver vibrational stimulation to peripheral nerves in Parkinson's disease patients, which the company says is intended to decrease stiffness, slowness, and freezing of gait. The system includes an app to track symptoms and quality-of-life measures. (Source: Business Weekly)

Clinicians Report Observations of Pediatric Epilepsy Patients Following Responsive Neurostimulation

December 2021 - A multicenter retrospective observational study presents preliminary data about safety and efficacy in the off-label use of responsive neurostimulation in pediatric patients with drug-resistant epilepsy. (Source: Neurosurgery)

Article Reports on Lower-Limb Neuromodulation for Chronic Pain Following Traumatic Injury

Nov. 24, 2021 - A team of co-authors report on use on an implantable neuromodulation device in the lower limb as an adjunctive procedure in patients who have continued chronic pain after failed revisional microneurosurgery in a nonreconstructable zone of injury. (Source: Clinics in Podiatric Medicine & Surgery)

University Prize Awarded to Neuromodulation Researcher in Switzerland

Nov. 23, 2021 - A neuromodulation researcher has been awarded a 2021 ETH Zurich Latsis Prize, worth CHF 25,000 ($26,762). The recipient's work includes development of a lower limb prosthesis with sensors and a neural interface, which provides above-knee amputees sensation when their prosthetic foot touches the ground. (Source: ETH Zurich)

Researchers Report Recent Data in Studies of Deep Brain Stimulation for Depression

Nov. 22, 2021 - A news article recounts recent developments in research into personalization of deep brain stimulation for treatment-resistant depression, including recently published data. (Source: Science)

Brain-Injured Hockey Player's Neurorehabilitation Includes Neuromodulation

Nov. 19, 2021 - A human-interest article describes how a former ice hockey player, who had a traumatic brain injury three years ago, is undergoing intensive neurorehabilitation now that incorporates a noninvasive portable neuromodulation system intended to foster brain plasticity during the training. (Source: Sportsnet.ca)

Case Report: Noninvasive Vagus Nerve Stimulation in Patients with COVID-Related Acute Respiratory Distress Syndrome

Nov. 18, 2021 - Nemechek Technologies reported that two case reports were published on two individuals who recovered from COVID-19-induced acute respiratory distress syndrome after being treated with transcutaneous auricular vagus nerve stimulation. (Source EIN Presswire)

Study Investigates Noninvasive Brain Stimulation and Cognitive Approaches in Problem-Solving

Nov. 18, 2021 - Researchers in Japan studied repetitive transcranial magnetic stimulation and cognitive behavior related to "giving up" during problem solving. (Source: Medical Xpress)

Survey Group Seeks Respondents Concerning Neurostimulation Treatment

Nov. 17, 2021 - A working group at LIverpool University is looking for people to take part in a survey on implantable neurostimulation devices. (Source: OUCH(uk))

Researchers Study Laser-Evoked Potentials During Chronic Pain Treatment with Dorsal Root Ganglion Stimulation

Nov. 16, 2021 - Researchers studied the rate that laser-evoked potentials recovered in patients who had been implanted with dorsal root ganglion stimulation systems to treat chronic neuropathic leg or groin pain. The authors hypothesize that recovery of the laser-evoked potentials may reflect therapy-induced changes in the nociceptive system. (Source: Pain Practice

Brain-Computer Interface System Receives FDA Breakthrough Device Designation

Nov. 17, 2021 - Blackrock Neurotech LLC has received FDA Breakthrough Device designation for its Moveagain brain-computer interface system. The company said it hopes to commercialize the implant in 2022. The system is intended to allow tetraplegic patients to control devices from their brain. (Source: Fierce Biotech)

Interview Series Installment Features Neuromodulation and Functional Neurosurgery

Nov. 17, 2021 - University of Illinois College of Medicine Prof. Konstantin Slavin, MD, chief of Stereotactic and Functional Neurosurgery, spoke in a 30-minute interview about the current and future evolution of neuromodulation therapies. (Source: Machine Medicine)

$2 Million Grant Will Support Noninvasive Brain Stimulation Research Over Five Years for Post-Stroke Aphasia

Nov. 16, 2021 - Researchers in New Mexico have received a $2 million grant from the National Institute on Deafness and Other Communication Disorders to study combining treatment for post-stroke aphasia with noninvasive brain stimulation meant to enhance brain plasticity, high-definition transcranial direct current stimulation. (Source: University of New Mexico)

Company Announces Opioid-Use Disorder Research Study

Nov. 16, 2021 - With a $2.49 million grant from the National Institutes of Health HEAL Initiative, Spark Biomedical plans to launch a clinical trial in January 2022 to further study transcutaneous auricular neurostimulation during acute detoxification for opioid use disorder (Phase I) and relapse prevention (Phase II). The treatment arms involve using active or placebo stimulation in combination with active or placebo medication. (Source: Globe Newswire)

Patient Enrollment Complete in a Clinical Trial of a Neurostimulation Device for Overactive Bladder

Nov. 16, 2021 - Bluewind Medical Ltd. announced it has completed enrollment in the OASIS clinical study of the company's RENOVA™ iStim tibial nerve stimulation system for treatment of overactive bladder. (Source: PR Newswire)

Study: Deeper Brain Structures and Transcranial Electrical Stimulation

January - February 2022 - Researchers reported about electric fields in deep human brain structures in conjunction with transcranial electrical stimulation. Their studies involved seven subjects who were undergoing brain monitoring for epilepsy. (Source: Brain Stimulation)

Company Receives Breakthrough Device Designation for a Chronic Cluster Headache Device

Nov. 15, 2021 - The Belgian company Man & Science received an FDA Breakthrough Device Designation for its neuromodulation intervention to treat chronic cluster headache, an occipital nerve field stimulation system. (Source: FDA News)

Grant Funds University Research on Neurostimulation as a Potential Therapy for Addiction

Nov. 4, 2021 - The University of Minnesota's Center for Neural Circuits in Addictions received a $100,000 grant from the National Institutes on Drug Abuse to continue research on neurostimulation as a potential addiction treatment. (Source: University of Minnesota)

Neurostimulator Company Plans U.S. Pivotal Trial in Generalized, Drug-Resistant Epilepsy

Nov. 10, 2021 - NeuroPace, Inc. announced receiving Investigational Device Exemption from the U.S. FDA to study its responsive neurostimulation system in patients with drug-resistant idiopathic generalized epilepsy. The pivotal study, NAUTILUS, is expected to begin enrolling patients in 2022. (Source: Globe Newswire)

Comparative Study Looks at Neurostimulation in Parkinson's Disease Patients with Sleep Apnea

Nov. 6, 2021 - A study of deep brain stimulation in Parkinson's disease compared outcomes in 22 patients who had mild to moderate sleep apnea with 28 who did not. (Source: AJMC)

Company Announces FDA Clearance for Noninvasive Brain Stimulation Platform

Nov. 2, 2021 - Magstim announced FDA clearance for a navigated transcranial magnetic stimulation platform with analytics and workflow components. (Source: Mass Device)

U.S. Patient Begins Pilot Study of Pulmonary Nerve Stimulation in Heart Failure

Nov. 2, 2021 - Cardionomic, Inc. announced initial U.S. enrollment in a pilot study of cardiac pulmonary nerve stimulation in patients with acute decompensated heart failure. (Source: PR Newswire)

Companies Announce Data Integration Project for Patients Receiving Deep Brain Stimulation for Parkinson's Disease

Nov. 2, 2021 - A collaboration between Rune Labs and Medtronic plc involves remote patient monitoring for 12 months in up to 1,000 Parkinson's disease patients whose deep brain stimulation systems can record local field potentials. Data shared with their treating physicians will also include patient-reported symptoms, medication dosing, and information from a wearable device. (Source: Yahoo News)

Proof-of-Concept Study Explores Closed-Loop Brain Stimulation and Cognitive Control

Nov. 2, 2021 - A proof-of-concept study in patients undergoing epileptic monitoring demonstrated participants' relative cognitive control during a conflict task when they received closed-loop direct stimulation of sub-parts of the internal capsule vs. open-loop stimulation. The closed-loop stimulation was applied when they were having difficulty with a laboratory test of cognitive control. Investigators also reported comparative effects on anxiety and the ability to shift focus. (Source: Genetic Engineering and Biotechnology News)

New Startup is Pursuing Commercialization of Depression Treatment

Oct. 29, 2021 - A new startup, Magnus Medical, exited stealth mode with $25 million in early funding, and a Breakthrough Device designation from the FDA for noninvasive neurostimulation treatment for severe depression. The treatment combines transcranial magnetic stimulation with digital imaging scans to tailor the neurostimulation individually. (Source: Fierce Biotech)

Case Report: Patient-Specific Tractography and Current Steering to Resolve Life-Threatening Post-Implantation Dyskinesias

Oct. 14, 2021 - A team of co-authors present their experience combining patient-specific tractography and current steering to resolve a case of severe life-threatening dyskinesias due to a persistent microlesion effect after implantation of deep brain stimulation leads targeting the subthalamic nucleus. (Source: Stereotactic and Functional Neurosurgery)

Researchers Share Interim Results of Brain Stimulation for Depression

Oct. 29, 2021 - Researchers published an interim analysis, in 29 participants after 4 weeks of treatment, in a randomized controlled study of deep brain stimulation in treatment-resistant depression. (Source: American Journal of Psychiatry)

Noninvasive Brain Stimulation System Released in U.S. for Therapeutic, Diagnostic Applications

Oct. 22, 2021 - Nextstim Plc announced the launch of a new navigated transcranial magnetic stimulation system configuration, NBS5+, in the U.S. (Source: Globe Newswire)

Company Developing Neurostimulation Treatment for Spinal Cord Injury Has Initial Public Offering

Oct. 21, 2021 - A Swiss startup focused on noninvasive electrical stimulation for functional recovery after spinal cord injury, ONWARD Medical, raised CHF93 million in an initial public offering on Euronext Brussels and Euronext Amsterdam. (Source: Startupticker.com)

$11.3 Million Grant Will Fund Projects in Deep Brain Stimulation for Parkinson's Disease

Oct. 25, 2021 - The National Institute for Neurological Disorders and Stroke awarded researchers at the University of Minnesota $11.3 million to continue work on projects to help further how treatment with deep brain stimulation may address symptoms of Parkinson's disease. (Source: News-medical.net)

Biomechanics Expert Studies Researches Sprain Rehabilitation with Transcranial Direct Current Stimulation

Oct. 19, 2021 - Researchers are undertaking a sham-controlled study of transcranial direct current stimulation during rehabilitation from ankle sprain to improve stability and decrease chances of recurrence. (Source: Appstate.edu)

Peripheral Nerve Stimulator Receives FDA Expanded Indication

Oct. 20, 2021 - The FDA has cleared an indication expansion to the head, neck and torso for SPR Therapeutics' Sprint peripheral nerve stimulator, which was previously cleared for use in the back and extremities. (Source: Pain Medicine News)

Phase I Results Presented in Study of Deep Brain Stimulation in Stroke

Oct. 20, 2021 - Phase I results were presented at the annual meeting of the Congress of Neurological Surgeons regarding a clinical trial of deep brain stimulation to the dentate nucleus in patients who had post-stroke hemiparesis of the upper extremities. The single-arm, open-label study enrolled 12 patients. The investigators said they are now planning a randomized, sham-controlled Phase II study in up to 40 patients. (Source: Medical Xpress)

Company Issues Field Safety Notice in Europe

Oct. 20, 2021 - According to a news report, Medtronic issued a field safety notice to European healthcare providers saying that based on four reported instances, its Percept PC deep brain stimulation implant may stop working and need removal after a patient with the device has a cardioversion, which sends electric shocks to the heart to restore a fast or irregular heartbeat to a normal rhythm. (Source: Fierce Biotech)

Researchers Report on Electrical Stimulation of the Visual Cortex of a Blind Person

Oct. 19, 2021 - A research team reports on implantation of a microelectrode array in the visual cortex of a blind individual. The intracortical array was left in place for six months as part of a registered clinical trial in Spain. (Source: The Journal of Clinical Investigation)

Startup to License Neurostimulation Intellectual Property

Oct. 19, 2021 - The Feinstein Institutes for Medical Research announced an exclusive agreement to license neurostimulation patents and patent applications to Neuvotion, a startup that was founded by a professor from the organization's Institute of Bioelectronic Medicine. The startup raised $1 million in seed funding and is pursuing therapies for movement disorders or impairments resulting from stroke or injury. (Source: Innovateli)

Health Canada Expands Use of Noninvasive Brain Stimulation for Migraine Treatment to Patients Aged 12 and Older

Oct. 19, 2021 - The company electroCore has received an amended medical device license from Health Canada that allows expansion of the label for its gammaCore noninvasive vagus nerve stimulator for use in acute and preventive treatment of migraine in adolescents aged 12 - 17. (Source: FDA News)

Company Announces Migraine Study

Oct. 19, 2021 - Theranica announced publication of a study that evaluated its remote electrical neuromodulation system for acute treatment of migraine in chronic migraine patients. (Source: NeuroNews)

Results Presented Concerning External Trigeminal Nerve Stimulation in Migraine

Oct. 19, 2021 - Findings were presented at the 2021 Annual Meeting of the American Neurological Association from a randomized, double-blind, sham-controlled trial of external trigeminal nerve stimulation for acute treatment of migraine. (Source: Medscape)

Peripheral Nerve Stimulation Device Company Raises $37 Million

Oct. 18, 2021 - SPR Therapeutics announced it has raised $37 million in Series D funding to support commercialization of its peripheral nerve stimulation system for pain relief. (Source: Globe Newswire)

Company Seeks FDA Device Clearance for Treatment of Fibromyalgia

Oct. 7, 2021 - NeuroMetrix has submitted a request to the FDA for de novo clearance of the Quell external neurostimulation system as a prescription treatment for chronic pain symptoms of fibromyalgia. (Source: Seeking Alpha)

Authors Present Evidence for a Common Neurostimulation Treatment Pathway in Essential Tremor

Oct. 4, 2021 - A team of co-authors retrospectively analyzed a cohort of individuals with essential tremor who had been treated with unilateral deep brain stimulation. To predict outcome of stimulation targets that share a common tract, the authors correlated percentage of contralateral improvement with structural connectivity measures using normative connectomes. (Source: NeuroImage: Clinical)

Observational Study Investigates Pulse-Dosing of Spinal Cord Stimulation and Recharge Patterns

Oct. 2, 2021 - A prospective, multicenter, observational study investigated intermittent stimulation with 10 kHz spinal cord stimulation and device recharge time. (Source: Pain Medicine)

Scientists Publish Meta-Analysis of Noninvasive Brain Stimulation for Cognitive Performance

Oct. 5, 2021 - A team of scientists in Korea conducted a meta-analysis of studies about transcranial direct-current stimulation as a technique to improve cognitive performance. (Source: Technology Networks)

Review Presents Findings About Deep Brain Stimulation for Tremor in Multiple Sclerosis

Oct. 5, 2021 - A systematic review and meta-analysis presents findings about deep brain stimulation for tremor in multiple sclerosis and other effects from the intervention. (Source: Multiple Sclerosis News Today)

Study Participant Describes Her Experience with Personalized Brain Stimulation to Treat Depression

Oct. 4, 2021 - In Nature Medicine, a study team described delivery of personalized deep brain stimulation for depression in one patient participating in their study, which makes use of a responsive neurostimulation system originally developed to sense and limit epileptic seizure activity. (Source: CNN)

Studies Compare Subperception, Other Modalities, of Spinal Cord Stimulation

Sept. 28, 2021 - Data presented at the mid-year meeting of the North American Neuromodulation Society compared subperception spinal cord stimulation (SCS) with other SCS modalities. (Source: Pain Medicine News)

Investigator Discusses Spinal Cord Stimulation for Painful Diabetic Neuropathy

Sept. 29, 2021 - An interview focuses on the recent FDA approval of a high-frequency spinal cord stimulation system for painful diabetic neuropathy. (Source: NeuroNews)

Researchers Share Data on COVID-19 Patients Treated with Vagus Nerve Stimulation

Sept. 29, 2021 - In a pre-print, data were published from the SAVIOR-1 study of noninvasive vagus nerve stimulation in hospitalized patients who had active SARS-CoV-2 infection. (Source: Street Insider)

Article Highlights Differences Between Adaptive and Conventional Deep Brain Stimulation in Parkinson's Disease

Sept. 29, 2021 - An article summarizes a study that compared conventional and adaptive deep brain stimulation in Parkinson's disease, (Source: DocWire News)

Researcher Presents Response-Rate Changes Over 60 Days in Pain Patients Who Received Peripheral Nerve Stimulation

Sept. 29, 2121 - A study presented at PAINWeek 2021 retrospectively tracked changes in response rates in patients who received percutaneous peripheral nerve stimulation for 60 days. (Source: Pain  Medicine News)

Clinical Trial Participant Discusses His Experience with a Brain Stimulation Intervention for Addiction

Sept. 29, 2021 - A television segment features a man who is participating in a clinical trial of deep brain stimulation for treatment-resistant addiction. (Source: WSAZ)

One-Year Outcomes Published in Clinical Trial of Restorative Neurostimulation in Refractory Mechanical Chronic Low Back Pain

October 2021 - Clinicians have published results in an international randomized, double-blind, sham-controlled trial of an implantable neurostimulator designed to restore multifidus control and relieve symptoms. Their article reported 12-month outcomes in 204 patients with refractory mechanical chronic low back pain. (Source: Pain)

Observations Published of Pediatric Epilepsy Patients with Responsive Neurostimulation Systems

Sept. 15, 2021 - A team of co-authors published a multicenter retrospective observational study of 35 pediatric patients and young adults with epilepsy who were implanted with a responsive neurostimulation system. (Source: Neurosurgery)

Institute Pursues a Vagus Nerve Stimulator for Type 2 Diabetes

Sept. 28, 2021 - The recently formed Neo-Bionica Institute is developing an implantable vagus nerve stimulator for people with Type 2 diabetes to activate after meals in order to potentially stimulate insulin production and regulate blood sugar levels. (Source: 9 News)

Company Undertakes Preclinical Work on Neurostimulator to Potentially Treat ALS

Sept. 27, 2021 - The U.S. National Institute of Neurological Disorders and Stroke awarded PathMaker Neurosystems a $371,000 Small Business Technology Transfer grant to complete investigations, in mouse models of amyotropic lateral sclerosis, of its NeuralSynchronizer external device that targets multiple sites in the spinal cord to reduce nerve activation, to suppress motor neuron hyperexcitability. (Source: ALS News Today)

Clinicians Study Peripheral Nerve Stimulation for Pain Following Leg Amputation

Sept. 27, 2021 - A pilot study compared peripheral nerve stimulation to standard medical therapy alone in patients following lower-limb amputation. The patients were followed for three months to track effects on acute and sub-acute post-amputation pain. (Source: Anesthesiology News)

Study Investigates Tractography in Essential Tremor Treatment

Sept. 25, 2021 - Using tractography after deep brain stimulation surgery, researchers investigated the dentato-rubro-thalamic tract with the highest correspondence to intraoperative tremor control in patients with essential tremor. They used the depiction to evaluate short-term postoperative adverse and beneficial effects. (Source: DocWire News)

Study Will Evaluate Neurostimulation in Post-Traumatic Stress Disorder

Sept. 10, 2021 - The National Institutes of Health and the U.S. Centers for Disease Control have granted $700,000 for a sham-controlled study of transcutaneous auricular nerve stimulation in chronic post-traumatic stress disorder in first responders to the 2001 attack on the World Trade Center. (Source: BioWorld)

Researchers Conduct a Cost-Benefit Analysis for Spinal Cord Stimulation

Sept. 24, 2021 - Researchers developed a probabilistic cost-effectiveness analysis that compared conventional medical management with, and without, spinal cord stimulation over five years in patients with failed back surgery syndrome in Spain. (Source: Journal of Pain Research)

Patient Enrollment Starts in Neurostimulation Trial in Depression

Sept. 23, 2021 - Neurolief Ltd. announced enrollment of the first patient in its pivotal clinical study of its noninvasive brain stimulation system as a potential adjunctive treatment for depression. (Source: Business Wire)

Multicenter Trial Investigates Upper Extremity Rehabilitation and Noninvasive Brain Stimulation in Stroke Patients

Sept. 23, 2021 - At the European Stroke Organisation Conference (ESOC) 2021, results were presented of a prospective, randomized trial in 119 patients with mild to moderate stroke who received rehabilitation for upper extremity function that was combined with either sham or active transcranial direct current stimulation. (Source: Medscape)

Researchers Study Effects of Neurostimulation on Lower Limb Rehabilitation After Stroke

Sept. 21, 2021 - In a pilot randomized controlled trial, clinicians compared physical rehabilitation in subacute stroke that had task-specific training for gait and lower limb performance with, or without, transcranial direct current stimulation. (Source: Neuromodulation: Technology at the Neural Interface)

Materials Research Aims to Reduce Friction in Brain Electrical Leads

Sept. 23, 2021 - Researchers in Korea published their development of a lubricated non-immunogenic probe that an article says may have an application in deep brain stimulation leads, potentially reducing insertion effects through decreasing surface friction. (Source: Parkinson's News Today)

Grant Will Fund Research on Providing Sensory Feedback in Prosthetic Limbs

Sept. 22, 2021 - The U.S. National Institute of Neurological Disorders has awarded a biomedical engineer at the University of Houston $2.8 million for a research project to improve the control of robotic limbs and provide natural sensory feedback from robotic prostheses to amputees. (Source: University of Houston)

Company Plans to Pursue Translational Research for an Auditory Nerve Implant

Sept. 15, 2021 - Blackrock Neurotech announced plans to fund preclinical studies and a pilot clinical trial in the development of an auditory nerve implant device that the company has worked on in collaboration with the University of Minnesota, MED-EL, Hannover Medical School (MHH), Feinstein, and the University of Utah. In 2019, the project received a $9.7 million grant from the National Institutes of Health. (Source: PR Newswire)

Clinicians Publish a Retrospective Case Series of Spinal Cord Stimulation Patients

Sept. 8, 2021 - A cases series of spinal cord stimulation patients at the Cleveland Clinic from 2000 to 2005 examined indications and complications. (Source: Pain Practice)

Study Examines Dystonia Genotypes and Response to Neurostimulation Treatment

Sept. 22, 2021 - Researchers assessed 396 patients with dystonia who had at least 12 months of follow-up from deep brain stimulation (DBS) surgery to compare responses to treatment based on different genotypic mutations. (Source: Neurology Today)

Noninvasive Brain Stimulation Offered for Smoking Cessation Treatment

Sept. 20, 2021 - A smoker describes receiving transcranial magnetic stimulation treatment at a South Carolina university medical center to quit smoking. (Source: MUSC)

Study Compares Anatomic and Paresthesia-Based Neurostimulation Lead Placement

Sept. 15, 2021 - A study in Neuromodulation: Technology at the Neural Interface compared spinal cord stimulator (SCS) placement using either paresthesia mapping or anatomic approaches in patients who received burst SCS systems for chronic low back pain. (Source: NeuroNews International)

Neurotech Company Raises Almost $23 Million in Venture Funding

Sept. 16, 2021 - The neurotech data company Rune Labs has raised $22.8 million in Series A financing. The company combines electophysiology, imaging, and device data for therapy development. (Source: Fierce Biotech)

Show Features Prosthetic Limbs with Neural Interfaces

Sept. 1, 2021 - A national public television segment in the U.S. highlights research to add a sense of touch to prosthetic limbs through a neural interface. (Source: PBS News Hour)

Sleep Apnea Device Receives Breakthrough Designation

Sept. 14, 2021 - Nyxoah SA announced the U.S. FDA gave Breakthrough Device designation to its hypoglossal nerve stimulation system for adults with obstructive sleep apnea and complete concentric collapse of the soft palate. (Source: Globe Newswire)

FDA Expands Company's Neurostimulator Device Labeling to Include Two More Head Pain Conditions

Sept. 14, 2021 - The company electroCore announced clearance from the FDA that expands the indications for its noninvasive vagus nerve stimulator, gammaCore, to the conditions paroxysmal hemicrania and hemicrania continua. The FDA had previously cleared the device for acute and preventative treatment of cluster headache. (Source: Street Insider)

Study Tracks Ongoing Compliance with Percutaneous Tibial Nerve Stimulation

Sept. 13, 2021 - A recently presented study of patients with overactive bladder assessed their continuance of percutaneous tibial nerve stimulation treatment, and examined factors such as symptom improvement and a history of neurologic issues, such as neurogenic bladder. (Source: Renal & Urology News)

Abu Dhabi Clinic Provides Pain-Management Neuromodulation Treatments

Sept. 11, 2021 - The Cleveland Clinic Abu Dhabi has begun performing peripheral nerve stimulation treatments to help patients manage chronic pain. (Source: Gulf News)

Collaborators Announce Development of an Open-Source System that May Enable an Optogenetic Neuromodulation Platform

Sept. 10, 2021 - As part of a project aimed toward translation to an implantable device for humans, collaborators in the U.K. and China are developing an open-source system to enable optogenetic neural modulation using custom hardware and algorithms. (Source: Frontiers in Neuroscience)

The BRAIN Initiative Funds a Brain-Computer Interface Project Potentially Relevant to Epilepsy Treatment

Sept. 9, 2021- Through its BRAIN Initiative, the National Institutes of Health is providing $12.25 million in a multi-institutional grant to develop high-density electrode arrays and probes intended for eventual human trials as potential devices for use in drug-resistant epilepsy. (Source: UC San Diego)

Grant Supports Pilot Project on Potential Cranial Nerve Electrode for Degenerative Brain Disease

Aug. 20, 2021 - The National Institute of Biomedical Imaging and Bioengineering has provided researchers at the University of Wisconsin a $300,000 grant to develop pilot data demonstrating the concept of an injectable, self-curing polymer electrode for potential use as a prophylactic strategy to stimulate cranial nerves to clear misfolded proteins in the brain that cause degenerative diseases such as Parkinson’s and Alzheimer’s. (Source: University of Wisconsin)

Article About Canadian Epilepsy Patient Explains Neuromodulation Therapy

Sept. 7, 2021 - An article focuses on a family whose son with epilepsy received deep brain stimulation following treatment with vagus nerve stimulation, and explains neuromodulation therapy in general. (Source: Toronto Life)

Researchers Present Feasibility Study of Low-Energy Spinal Cord Stimulation

Sept. 7, 2021 - An early feasibility study of differential target multiplexed spinal cord stimulation was presented at the annual meeting of the American Society of Interventional Pain Physicians. (Source: Pain Medicine News)

Study Reports Epilepsy Patients' Experiences with Brain Stimulation

Sept. 7, 2021 - A study followed 12 epilepsy patients and their family caregivers over two years to assess their experiences with implanted brain stimulation devices, including the patients' sense of self-perception. (Source: Healthday)

Researchers Compare Rechargeable and Non-rechargeable Spinal Cord Stimulators

Aug. 29, 2021 - Researchers retrospectively analyzed healthcare utilization and other measures in 150 chronic pain patients in Germany who received a rechargeable device (49%) and those who received a non-rechargeable device (51%). (Source: Journal of International Medical Research)

Authors Recommend Educating Diabetes-Care Providers About Neuromodulation

Sept. 7, 2021 - Researchers analyzed a clinical database and referral patterns to anticipate utilization of neuromodulation as an emerging treatment for patients with painful diabetic neuropathy. (Source: Frontiers in Pain Research)

Review Focuses on Neural Dosing

Sept. 7, 2021 - A review focuses on "the preclinical and clinical knowledge base" for insights that may help develop approaches to neural dosing in spinal cord stimulation. (Source: Journal of Pain Research)

Noninvasive Method Stimulates Corticospinal Excitability in Lower Limbs

Sept. 7, 2021 - In healthy volunteers, co-authors in Japan and Canada studied paired associative stimulation with transcutaneous spinal cord stimulation to the posterior spinal root, stimulating sensory nerves of lower-limb muscles, and investigated the effects on corticospinal excitability of those muscles for potential insights into their neuroplasticity relevant to neurorehabilitation. (Source: Neuroscience)

Authors Discuss a Data Infrastructure Role for Next-Generation Deep Brain Stimulation Therapies

Sept. 6, 2021 - In a perspective article, co-authors from Rune Labs and the University of California, San Francisco discuss the potential for a cloud-based data infrastructure that might support individualized treatment with so-called precision neuromodulation. (Source: Frontiers in Human Neuroscience)

Researchers Report Followup of Pain Patients Treated with Restorative Neurostimulation

Sept. 3, 2021 - Researchers published a two-year followup of 42 patients who were treated for chronic mechanical low back pain with restorative neurostimulation. (Source: Pain and Therapy)

Project Uses ECG Data to Model Brain Connectivity

Sept. 3, 2021 - Researchers developed and released an algorithm designed to better understand which brain regions directly interact with one another, and note that interaction's bearing on neurostimulation therapy for Parkinson's disease or epilepsy. (Source: Science Daily)

European Investigators Publish Study of Occipital Nerve Stimulation for Cluster Headache

Sept. 2, 2021 - Investigators published results of a clinical trial of occipital nerve stimulation for chronic cluster headache that assessed stimulation intensity of either 100% or 30% over 24 weeks. (Source: Clinical Pain Advisor)

Biomedical Engineers Add Neural Interface to Bionic Arm

Sept. 1, 2021 - An article details development of a prosthetic arm at the Cleveland Clinic that uses a neural-machine interface to provide a sense of touch and kinesthesia as well as motor control. (Source: CNET)

Company Plans Clinical Trial of Wearable Stimulation Device in Alzheimer's Disease

Sept. 2, 2021 - Scion NeuroStim has posted a clinical trial of noninvasive brainstem modulation device in subjects with mild, late-onset Alzheimer's disease, the WeArable Neuromodulation DeVice for the TrEatment of Alzheimer's Disease (WAVE-AD) study. (Source: Clinicaltrials.gov)

FDA Clears Electrical Stimulation Device for Prevention of Pressure Sores

Sept. 1, 2021 - An external device that provides intermittent electrical stimulation to create muscle contraction, Prelivia, has received FDA clearance to prevent pressure injuries by stimulating blood flow. (Source: Medical Product Outsourcing)

Researcher Models Deep Brain Stimulation for Potential Adaptive Systems

Sept. 1, 2021 - Research at the University College Dublin aims to apply computer modeling of deep brain stimulation (DBS) for movement disorder to develop adaptive stimulation, through embedding a smart algorithm in the device that can sense biomarkers and adjust stimulation parameters automatically. The research involves collaboration with a Dublin-based neurosurgeon who recently began providing DBS services there. (Source: Irish Times)

Paper Presents Data on Motor Symptom Effects of Deep Brain Stimulation of the Fields of Forel

September 2021 - Clinicians studied the effect of deep brain stimulation that targets a deep brain structure, the fields of Forel, on gait and balance disturbance in patients with Parkinson's disease. (Source: Neurosurgery)

Study Investigates Brain Plasticity and Responsiveness to Neurostimulation Treatment in Patients with Epilepsy

Aug. 30, 2021 - An investigator analyzed EEG recordings from 51 epilepsy patients who'd received responsive neurostimulation systems, comparing their responsiveness to the therapy to the extent that their functional connectivity reorganized within the first year. (Source: Neurology Today)

Researchers Analyze Cost-Effectiveness of Responsive Neurostimulation for Epilepsy

Aug. 29, 2021 - A team of co-authors published an analysis of the cost-effectiveness of responsive neurostimulation for drug-resistant focal-onset epilepsy. (Source: Epilepsia)

Vagus Nerve Stimulation Device Receives FDA Approval for Stroke Motor Rehabilitation

Aug. 27, 2021 - The U.S. FDA has approved MicroTransponder's Vivistim implantable vagus nerve stimulation system to aid in physical rehabilitation of motor function of the upper extremities in patients with chronic ischemic stroke. (Source: Mass Device)

Study Assesses Burst Mode of Vagus Nerve Stimulation and Heart Rate

Aug. 26, 2021 - In a pilot study, researchers assessed a novel burst paradigm for auricular vagus nerve stimulation in 42 healthy young adults. The assessment included responder rate, and heart-rate variability, comparing the novel mode to both sham and tonic stimulation. (Source: Neuromodulation: Technology at the Neural Interface)

Review Focuses on Implantable Pulse Generators for Deep Brain Stimulation

Aug. 26, 2021 - A review summarizes considerations concerning existing implantable pulse generators, and emerging technologies, for deep brain stimulation. (Source: Frontiers in Human Neuroscience)

Academic Researchers Release Neurostimulation Modeling Software

Aug. 26, 2021 - A university-developed open-source software platform has become available that automates modeling of electrical nerve stimulation in three dimensions, for predicting how specific nerves will respond to different stimulation patterns from custom electrodes. Its four-year development was funded by the National Institutes of Health Common Fund's Stimulating Peripheral Activity to Relieve Conditions program (SPARC) program. (Source: Medical Xpress)

Study Assesses Noninvasive Brain Stimulation Effect on Gait in Parkinson's Disease

Aug. 25, 2021 - In a randomized, double-blind, sham-controlled crossover study, researchers studied the effect of transcranial direct current stimulation on exercise benefits for gait in patients with Parkinson's disease. (Source: Technology Networks)

National Institutes of Health $10 Million Grant Announced for Brain-Computer Interface Study

Aug. 26, 2021 - Synchron, Inc. announced a $10 million grant from the U.S. National Institutes of Health for a clinical trial of its Synchron motor neuroprosthesis. The clinical trial, COMMAND, will evaluate the company's Stentrode device in up to six individuals with paralysis to potentially enable some digital communication capabilities. (Source: Business Wire)

Researchers Test Ultra-Low Frequency Waveform in Subjects with Chronic Pain

Aug. 25, 2021 - A group of co-authors wrote that following animal studies, for two weeks, they tested the analgesic effects of epidural ultra-low frequency currents in 20 subjects who had chronic back and leg pain, checking changes in pain levels again one week after explanting the electrodes. (Source: Science Translational Medicine)

Pharmaceutical Company Partners with Neurostimulation Company on Bioelectronic Medicine

Aug. 23, 2021 - Merck announced it is partnering with neuroloop GmbH on development of neurostimulation for chronic inflammatory disease. (Source: Pharmafield)

Study Assesses Home-Based Followup Care for Deep Brain Stimulation Patients

Aug. 23, 2021 - A randomized trial in JAMA Neurology compared standard-of-care treatment to home-based postoperative management in Parkinson's disease patients who received deep brain stimulation. (Source: AJMC)

Noninvasive Brain Stimulation Studied in Bradykinesia

Aug. 23, 2021 - A small study of transcranial direct current stimulation in Parkinson's disease patients assessed effects on upper limb bradykinesia. The stimulation targeted the supplementary motor area. (Source: Parkinson's News Today)

Clinicians Investigate Vagus Nerve Stimulation in Parkinson's Disease Patients with Freezing of Gait

Aug. 20, 2021 - A randomized, double-blinded crossover study of noninvasive vagus nerve stimulation in Nature https://www.nature.com/articles/s41531-021-00190-x tracked inflammatory cytokines and other biomarkers in Parkinson's disease patients, and recorded changes in motor symptoms, such as freezing of gait. (Source: Psychiatry Advisor)

Authors Present Published Findings About Deep Brain Stimulation of the Habenula

Aug. 17, 2021 - A team of co-authors published a systemic review of the literature and clinical trial registries concerning deep brain stimulation of the habenula, whose role has been indicated in some neuropsychiatric disorders. (Source: Psychiatry)

Authors Discuss Science and Clinical Application of Functional Connectivity Research

Nov. 15, 2021 - An article synthesizes concepts that have emerged from studies of brain functional connectivity in various conditions and over an individual's lifespan. Neuromodulation treatment that targets brain circuits is one of the immediate areas of clinical impact for this emerging understanding, the authors say. (Source: NeuroImage)

Article Traces Evolution of Spinal Cord Stimulation Therapies

Aug. 15, 2021 - A clinician briefly reviews the evolution in spinal cord stimulation methods, such as the emergence of closed-loop stimulation therapy and other new algorithms that provide sub-perception pain treatment therapy. (Source: Interventional Pain Medicine and Neuromodulation)

Analysis Assesses Burst Spinal Cord Stimulation Outcomes in Patients with Psychological Stress

Aug. 19, 2021 - Using data about burst spinal cord stimulation treatment from the prospective, multi-center, single-arm, international TRIUMPH study, investigators assessed outcomes in pain patients who had high psychological stress. (Source: Spine Journal)

Company Prepares for Commercial Launch of a Neurostimulator for Cluster Headache

Aug. 18, 2021 - Unity HA, which acquired the sphenopalatine ganglion stimulation system, Pulsante, for cluster headache from Autonomic Technologies, Inc., announced the company has been renamed Realeve to support commercialization of the device, which received FDA Breakthrough Device designation earlier this year. In addition, the company announced appointment of a new chief executive officer, industry veteran Jon Snyder. (Source: Business Wire)

Noninvasive Neurostimulator Receives FDA Breakthrough Designation to Aid Stroke Rehabiliation

Aug. 18, 2021 - The FDA has granted Breakthrough Device Designation to the Portable Neuromodulation Stimulator (PoNS) device from Helius Medical Technologies, for adjunctive use during physical rehabilitation of gait and balance following stroke. (Source: Medical Device Network)

Startup Envisions Merging Spinal Fusion Hardware with a Neuromodulation System

Aug. 16, 2021 - The medical device startup SynerFuse said it is working on a therapy for chronic low back pain that integrates spinal fusion hardware, an active neuromodulation system, and sensors in a novel "smart" device. (Source: Yahoo Finance)

Clinicians Publish an Alternative Implantation Approach for Dorsal Root Ganglion Stimulation

July 30, 2021 - In a tutorial, clinicians published an alternative implantation technique. Their paper is entitled, "A paramedian approach for dorsal root ganglion stimulation placement developed to limit lead migration and fracture". (Source: Pain Practice)

Spun-Out Company Will Focus on a Wearable Nerve Stimulator for Tourette Syndrome

Aug. 9, 2021 - To commercialize a wrist-worn peripheral nerve stimulation device for Tourette Syndrome, the University of Nottingham has spun-out a company, Neurotherapeutics Solutions Ltd. Worn like a wristwatch, the device produces a rhythmic stimulation. (Source: Medical Xpress)

Letter: Panel Proposes the New Term, Persistent Spinal Pain Syndrome

Aug. 2, 2021 - In a letter to the editor, several co-authors note that an independent international panel of 25 experts has proposed the term persistent spinal pain syndrome to replace "failed back surgery syndrome". (Source: European Journal of Pain)

Investigators Study Respiration-Gated Auricular Vagus Nerve Stimulation in Depression

Oct. 2021 - In a crossover study of subjects experiencing recurrent depression, investigators used transcutaneous auricular vagus nerve stimulation that was gated to inhalation or exhalation, comparing results and recording functional MRI scans one week apart. Their paper is entitled, "Respiratory-gated auricular vagal afferent nerve stimulation (ARVANS) modulates brain response to stress in major depression". (Source: Journal of Psychiatric Research)

Large Spinal Cord Stimulation Case Series Involved Preoperative Magnetic Resonance Imaging

Aug. 11, 2021 - A team of authors report on a series of 160 patients who were treated with spinal cord stimulation at an academic center from 2013 to 2021, and, as recommended in consensus guidelines, underwent preoperative imaging with MRI prior to placement of paddle electrodes. (Source: Neuromodulation: Technology at the Neural Interface)

Review: Noninvasive Brain Stimulation in Borderline Personality Disorder

Aug. 10, 2021 - A systematic review focused on published reports about transcranial magnetic stimulation in patients with borderline personality disorder. (Source: Healio)

Paper Reports on Transcranial Pulsed Ultrasound Stimulation in Patients with Alzheimer's Disease

Aug. 9, 2021 - An analysis evaluated the change in cortical thickness and cognitive function in 17 Alzheimer's disease patients following treatment with transcranial pulsed ultrasound stimulation as a potential add-on therapy. (Source: Medical Xpress)

Researchers Investigate Noninvasive Brain Stimulation in Post-Stroke Aphasia

Aug. 6, 2021 - A clinical trial at Syracuse University in New York is testing transcutaneous direct current stimulation in patients with aphasia from stroke in the left brain hemisphere. (Source: Medical Xpress)

Science and PINS Prize Honors a Neural Interface Project that is Developing Prosthetic "Sensing" for Lower-Limb Amputees

Aug. 6, 2021 - The Science and PINS Prize for Neuromodulation was given this year to Stanisa Raspopovic, whose peripheral-nerve interface project in the Department of Health Science and Technology at ETH Zürich is developing a "sensing leg" for lower-limb amputees (Source: Science)

Neurostimulator for Obstructive Sleep Apnea Receives FDA Nod

Aug. 5, 2021 - Zoll Medical, which acquired Respicardia in April, announced FDA approval of the next-generation Remedē  EL-X implantable neurostimulation system to treat severe sleep apnea.(Source: Mass Device)

Review Gathers Clinical Trial Evidence in Noninvasive Brain Stimulation for Nicotine Dependence

Aug. 4, 2021 - A systemic review of randomized controlled trials summarizes evidence regarding noninvasive brain stimulation for smoking cessation. (Source: News-medical.net)

Young Investigators Researching Neuromodulation for Behavioral Conditions Receive Acknowledgement

Aug. 4, 2021 - In prizes for young investigators who received grants from the Brain & Behavior Research Foundation, three of the six prizes were given for work involving neuromodulation in psychiatric conditions. (Source: Bakersfield.com)

Authors Report on Noninvasive Vagus Nerve Stimulation for COVID-19 Respiratory Symptoms

July 29, 2021 - An article reports on 51 patients who were hospitalized with COVID-19 pneumonia and received transcutaneous vagus nerve stimulation to address respiratory symptoms at a public hospital in Buenos Aires, Argentina. (Source: Journal of Emerging Diseases and Virology)

Crossover Trial Reported that Involved Connectivity-Based Deep Brain Stimulation Settings in Patients with Essential Tremor

Aug. 2, 2021 - A team of co-authors from the Mayo Clinic published a blinded trial in patients with essential tremor who were crossed over between connectivity-based deep brain stimulation settings, standard-of-care programming, and sham. The directional stimulation settings targeted the dentato-rubro-thalamic tract. (Source: The Neuroradiology Journal)

Article Reports Deep Brain Stimulation Outcomes in Dystonia

Aug. 2, 2021 - The extent of symptom improvement over time was reported for 67 patients with either generalized, cervical, or brain pathology-induced dystonias who underwent deep brain stimulation surgery between 2014 and 2020 at four centers in India, Kuwait, Egypt, and Turkey. (Source: Neurology International)

Clinical Trial Will Evaluate Voltage-Driven Deep Brain Stimulation in Patients with Treatment-Resistant Obesity

Aug. 2, 2021 - Physicians in Pittsburgh, PA received FDA clearance to enroll six patients with chronic refractory obesity in a pilot study of deep brain stimulation of the lateral hypothalamic area. (Source: PR Newswire)

Presentation Reports on Heart Patients Who Were Treated with Autonomic Nervous System Modulation

July 30, 2021 - Orchestra BioMed announced longterm followup data on hypertensive patients who were crossed over during a clinical trial from a control group to treatment with its implantable pulse generator that modulates autonomic nervous system function and provides standard pacemaker functions. The data were presented in a meeting of the Heart Rhythm Society. (Source: Globe Newswire)

Temporary Spinal Cord Stimulation Studied in Cardiac Surgery Patients

July 30, 2021 - In a late-breaking clinical trials presentation, researchers shared data from a randomized pilot study of perioperative spinal cord stimulation in patients with a history of paroxysmal atrial fibrillation who underwent coronary bypass surgery. (Source: MedPage Today)

Assistive Neurostimulator Receives Breakthrough Designation

July 21, 2021 - Synapse Biomedical Inc. announced the FDA has granted Breakthrough Device Designation to its percutaneous diaphragm stimulator that is designed to aid in weaning from mechanical ventilation, TransAeris. (Source: PR Newswire

Review Addresses Brain Stimulation in Alcohol-Use Disorders

August 2021 - A team of authors reviews evidence and methodological considerations in the use of brain stimulation in alcohol-use disorders. (Source: Comprehensive Psychiatry)

Study Proposes a Predictive Model of Individualized Brain Stimulation Treatment Using Functional Connectivity

July 28, 2021 - Researchers published a proof-of-concept study for individualized targeting of transcarnail magnetic stimulation (TMS) treatment. The study drew from data regarding 25 healthy controls and 93 participants with anxious misery, from a dataset entitled Dimensional Connectomics of Anxious Misery. They developed a proposed model that uses functional connectivity, symptom scores, and electric-field modelling to predict symptom change following a hypothetical course of TMS treatment. (Source: Neuropsychopharmacology)

Temporary Peripheral Nerve Stimulation Evaluated in Chronic Axial Low Back Pain

July 28, 2021 - A multicenter study of patients with axial low back pain evaluated pain scores in patients who used temporary peripheral nerve stimulation of medial nerves for two months, following the patients for five to eight months and beyond. (Source: Pain Medicine News)

Company Receives Nod for U.S. Clinical Feasibility Trial of Intravascular Brain-Machine Interface

July 28, 2021 - Synchron Inc. announced it has received an Investigational Device Exemption from the U.S. FDA to begin human feasibility studies there of its Stentrode device, which is implanted via a blood vessel in the brain, as a potential way to aid paralyzed patients to control digital devices, such as computer cursors. The U.S. study would enroll up to six patients, and follows clinical investigation in Australia involving four patients. (Source: Bloomberg)

FDA Presents Guidance on Non-clinical Testing and Clinical Considerations for Implanted Brain-Machine Interfaces for Patients with Loss of Limb Function

July 28, 2021 - On July 29, 2021, the U.S. Food and Drug Administration (FDA) will host a 90-minute webinar, starting at 11 a.m. U.S. Eastern time, for stakeholders interested in learning about its final guidance on "Implanted Brain-Computer Interface (BCI) Devices for Patients with Paralysis or Amputation - Non-clinical Testing and Clinical Considerations". Registration is not required, but calling in 15 minutes in advance is advised to allow time to connect. A transcript will be posted after the fact. (Source: FDA)

Subanalysis Evaluates Intermittent Burst Spinal Cord Stimulation

July 27, 2021 - In a subanalysis of the TRIUMPH  and REALITY clinical studies, "Ultra-Low Energy Cycled Burst Spinal Cord Stimulation Yields Robust Outcomes in Pain, Function, and Affective Domains: A Subanalysis From Two Prospective, Multicenter, International Clinical Trials," the utility was evaluated of using intermittently cycled burst spinal cord stimulation in patients with chronic pain. (Source: Neuromodulation: Technology at the Neural Interface)

Meeting Presentations Share Studies of Investigational Stimulation Approach for Alzheimer's Disease

July 26, 2021 - Cognito Therapeutics announced presentation of six posters about its gamma frequency stimulation therapy in mild to moderate Alzheimer's disease, The data presented at the Alzheimer's Association International Conference were gathered in a prospective Phase 2 study. (Source: Valdosta Daily Times)

Investigators Publish Analysis of Noninvasive Neurostimulation Trial in Fibromyalgia

July 26, 2021 - NeuroMetrix, Inc. announced publication of an analysis of a comparative trial in subjects with fibromyalgia who received either wearable transcutaneous nerve stimulation or sham treatment for three months at home. (Source: Globe Newswire)

Clinicians Report Experience with Adjunctive Infection Control Measure

July 23, 2021 - A retrospective review evaluated the effectiveness of an antibacterial envelope in reducing surgical site infection in spinal cord stimulator implant surgeries. (Source: Journal of Pain Research)

Study Compares Estimate Approaches for Evoked Compound Action Potentials

July 22, 2021 - A study compared schemes for estimating evoked compound action potentials based on data from patients undergoing a spinal cord stimulation trial. (Source: Neuromodulation: Technology at the Neural Interface)

Review Looks at Literature About Unilateral Deep Brain Stimulation in Parkinson's Disease

July 22, 2021 - A review summarizes evidence and controversies in the literature regarding effects of left- or right-sided deep brain stimulation in Parkinson's disease, both concerning motor and non-motor outcomes. (Source: NPJ Parkinson's Disease)

Researchers Study Neurostimulation Using Gamma Frequency Light or Sound

July 22, 2021 - An article describes emerging noninvasive brain stimulation using light or sound to stimulate the visual and auditory cortex at a gamma frequency. (Source: MD+DI)

Peripheral Nerve Stimulation Study Begins in Patients with Knee Pain

July 22, 2021 - Enrollment has begun in a clinical trial of a peripheral nerve stimulation device by Micron Medical Corporation, in patients with knee pain. (Source: Digital Journal)

Studies Suggest Brain Pathway for Obsessive Compulsive Disorder

July 19, 2021 - A review integrates findings in studies of brain connectivity networks at the cortical and subcortical level, plus deep brain stimulation, in patients with obsessive compulsive disorder, and proposes a unified network that may be modulated at different points. (Source: Biological Psychiatry)

Researchers Investigate Evoked Compound Action Potentials in Relation to Perception and Discomfort

July 12, 2021 - In a small study with potential application to neurostimulation programming, researchers looked at different postures and pulse widths of spinal cord stimulation in conjunction with estimates of thresholds for evoked compound action potentials, which were examined in relation to thresholds for perception and discomfort. (Source: Frontiers in Neuroscience)

Investigational Neurostimulation Treatment for Fibromyalgia Receives Breakthrough Designation

July 20, 2021 - NeuroMetrix, Inc. announced that its Quell noninvasive neurostimulation device received FDA Breakthrough Device Designation for treatment of fibromyalgia, following a double-blind, randomized, sham-controlled clinical trial. (Source: Globe Newswire)

Study Focuses on Neurostimulation in Cluster Headache

July 20, 2021 - In a study, occipital nerve stimulation reduced the frequency of medically intractable chronic cluster headaches. (Source: Healio)

Company Raises $65 Million for Pivotal Trial of Overactive Bladder Device

July 20, 2021 - Neuspera Medical has raised $65 million on a series C round of equity financing, with plans to use it for a pivotal clinical trial of its implantable neuromodulation device to address urinary urge incontinence in overactive bladder. (Source: PR Newswire)

Device Receives FDA Approval for Painful Diabetic Neuropathy

July 19, 2021 - Nevro Corp. announced FDA approval of its spinal cord stimulation system for the indication of painful diabetic neuropathy treatment with 10 kHz stimulation. (Source: PR Newswire)

Study Provides 12 Months of Data on Tibial Nerve Stimulator

July 15, 2021 - Twelve-month results were published in a prospective, single-arm, study of an implantable tibial nerve stimulator in patients with overactive bladder. (Source: Urology Times)

Presentation Describes Nanoparticles Under Development as Wireless Brain-Activity Sensors

July 15, 2021 - Researchers plan a presentation on injectable brain-activity sensors based on electro-plasmonic nanoparticles that convert electrical signals into optical signals that can be detected using near-infrared light. (Source: Phys.org)

Researchers Demonstrate Thought-to-Text Technology in a Paralyzed Individual

July 14, 2021 - Researchers published a demonstration of decoding words from brain activity via a brain-computer interface above the speech motor cortex in a person who lost the ability to speak due to stroke more than 15 years ago. At the same time, Facebook, which helped fund the research, indicated it is segueing its product development from a consumer headset or helmet to wrist-worn devices that use electromyography. (Source: The Verge)

Data Published About Transcutaneous Stimulation in Cerebral Palsy

July 13, 2021 - SpineX announced publication of data about the effect of transcutaneous electrical stimulation on posture and locomotion 12 children with cerebral palsy. (Source: Globe Newswire)

Investigational PTSD Device Wins Recognition

July 13, 2021 - An Israel-based company announced recognition for its investigational "self-neuromodulation" device for PTSD therapy, which provides audiovisual interface and tracks EEG signals. The company, GrayMatters Health, was among eight finalists for the Nature Spinoff Prize. (Source: PR Newswire)

Review Gathers Findings About Spinal Cord Stimulation in Multiple Sclerosis

July 10, 2021 - An article summarizes a systemic review of spinal cord stimulation in patients with multiple sclerosis who were experiencing motor disorders, urinary dysfunction, or neuropathic pain. (Source: AJMC)

Vagus Nerve Stimulation Studied in Long COVID

July 9, 2021 - A study of transcutaneous vagus nerve stimulation in patients with long-COVID syndrome was published by the Laboratory of Neurophysiology & Movement Biomechanics at the Université Libre de Bruxelles in Belgium and the Human Waves Clinic. (Source: European Pharmacological Review)

Turkish Startup sees Interest in Its Vagus Nerve Stimulator

July 9, 2021 - A vagus nerve stimulator with adjustable stimulation parameters, developed in Turkey, is being used for studies into autonomic nervous system issues, such as inflammatory response to infection. (Source: Daily Sabah)

Pharmaceutical Company Announces Vagus Nerve Stimulator Collaborations

July 8, 2021 - Merck KGaA has entered into a cooperative agreement with neuroloop GmbH, part of B. Braun Group, for development of a neurostimulator that adapts neuroloop's vagus nerve stimulation cuff that offers controllable selective stimulation. The agreement seeks to enable targeted treatment of chronic inflammatory diseases to complement existing drug therapies. In a related announcement, Merck is entering into a collaboration with Innervia Bioelectronics, a start-up and subsidiary of Inbrain Neuroelectronics S.L. of Barcelona for development of vagus nerve stimulation based on energy-efficient graphene. (Source: Global Legal Chronicle)

Device Maker Announces Licensing and Distribution Agreement

July 7, 2021 - Neurolief announced a licensing agreement to develop and market its noninvasive brain stimulation system for migraine and depression in greater China and South Korea. (Source: Business Wire)

Overactive Bladder Clinical Trial Continues Enrollment

July 6, 2021 - BlueWind Medical, Ltd. announced enrollment of the the 100th patient in its clinical pivotal study of its tibial neuromodulation therapy for overactive bladder. (Source: HJNews)

Device Maker Prices U.S. Offering

July 2, 2021 - Nyxoah SA, which is developing neurostimulation to treat obstructive sleep apnea, has priced a U.S. initial public offering at $30 per share, to raise US$85.1 million. The offering was expected to close on July 7, 2021. (Source: Globe Newswire)

News Segment Features Patient Who Received Neurostimulation for Complex Regional Pain Syndrome

July 2, 2021 - A patient who received spinal cord stimulation for complex regional pain syndrome that affected her feet is interviewed in a local television segment. (Source: WSAW)

Company Announces Grant of Up to $9.3 Million to Evaluate a Neurostimulation Treatment for Epilepsy

June 30, 2021 - NeuroPace, Inc. has received a National Institutes of Health grant from the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to provide up to $9.3 million over five years in order to evaluate its RNS neurostimulator in the treatment of a type of childhood-onset epilepsy, Lennox-Gastaut syndrome. (Source: Globe Newswire)

Noninvasive Brain Stimulation Receives Breakthrough Designation, Company Says

June 30, 2021 - Neuroelectrics announced its transcranial electrical stimulation system for refractory focal epilepsy has received breakthrough device designation from the FDA. (Source: Mass Device)

Researchers Study Noninvasive Brain Stimulation in Mild Anxiety

June 30, 2021 - Results of a small single-blind, randomized, sham-controlled study were published concerning effects of combining transcranial direct current stimulation with gamified attention bias modification training. (Source: BioSpace)

Company Announces Limited U.S. Launch of Neurostimulator for Back Pain

June 29, 2021 - Mainstay Medical announced its ReActiv8 implantable restorative neurostimulation system for intractable back pain will undergo a limited launch in the United States beginning this summer as physicians are trained and certified in its use. (Source: Mass Device)

Presentation of Innovative Neurological Devices Includes Neuromodulation Componesnts

June 29, 2021 - Directional deep brain stimulation and a flexible cortical electrode are among the technologies featured in a collection of emerging neurological devices. (Source: MD+DI)

Device Maker Raises $126 Million in Initial Public Offering

June 30, 2021 - CVRx issued 750,000 more shares than anticipated in its initial public offering, which opened at $18 per share, higher than the anticipated range of $15 to $17. The offering raised $126 million for the company, which makes a neuromodulation device for cardiovascular disease. (Source: Renaissance Capital)

Company Announces Public Offering

June 30, 2021 - The company electroCore, Inc. announced pricing of an underwritten public offering at $1 per share, with the offering expected to close on or about July 2, with gross proceeds of $18 million. (Source: Globe Newswire)

Amputee Discusses Neurostimulation Pain Relief

June 30, 2021 - A man whose hand was amputated after a fireworks accident last year received peripheral nerve stimulation for pain relief, in addition to a prosthesis that reads forearm muscle movement and provides the capacity for the hand to open, close, and grip. (Source: Wisconsin State Journal)

Company Anticipates Launch of Sacral Neuromodulation System

June 25, 2021 - Axonics Modulation Technologies announced it has filed a premarket approval supplement with the FDA for its non-rechargeable sacral neuromodulation system. (Source: Mass Device)

Publication Presents Deep Brain Stimulation in Schizophrenia

June 25, 2021 - A published case study described 12-month results in a patient with treatment-resistant schizophrenia, who received deep brain stimulation to the substantia nigra pars reticulata. (Source: Medical Xpress)

U.S. Study Will Gather Data on Vagus Nerve Stimulation in Treatment-Resistant Depression

June 24, 2021 - Enrollment has begun in Virginia in a randomized, prospective, controlled clinical trial https://clinicaltrials.gov/ct2/show/NCT03887715 of vagus nerve stimulation in treatment-resistant depression. (Source: WDBJ)

Company Announces First Novel Implantation Technique in Baroflex Stimulator Treatment

June 23, 2021 - CVRx announced the first clinical application of a new ultrasound-guided approach to placing a baroreceptor stimulation lead in a patient receiving the implant to address heart failure. (Source: MedTech Outlook)

Clinical Trial Assesses Noninvasive Stimulation in Urinary Incontinence

June 22, 2021 - In a clinical trial in women with mixed urinary incontinence, investigators compared symptoms and patient impressions of improvement in groups treated with either pelvic floor muscle training and transcutaneous tibial nerve stimulation or pelvic floor muscle training alone. (Source: MD Linx)

Case Series Tracks Neurostimulation Response by Gender

June 22, 2021 - A case series of 387 patients who received spinal cord stimulation or dorsal root ganglion for chronic pain documented pain severity at baseline and follow-up, treatment response and lead fractures or implants, stratified by age and gender. (Source: Neuromodulation: Technology at the Neural Interface)

Pilot Study of Vagus Nerve Stimulation in Patients with Long COVID

June 22, 2021 - A pilot study evaluated transcutaneous auricular vagus nerve stimulation in patients in Belgium who were experiencing symptoms of long COVID. (Source: Digital Journal)

Clinical Trial Will Investigate Neurostimulator to Improve Consciousness During Seizures

June 21, 2021 - A clinical trial will begin in September at three sites in patients with temporal lobe epilepsy, who will receive an implanted neurostimulator which is being investigated as a potential intervention to improve consciousness during seizures. (Source: Yale School of Medicine)

Data Analysis Looks at Lead Anchoring, Migration, and Fracture in Dorsal Root Ganglion Stimulation

June 18, 2021 - A multi-center pooled data analysis examined lead migration and fracture rate in dorsal root ganglion stimulation when using either anchoring and non-anchoring techniques. (Source: Pain Practice)

Meta-Analysis About Pain Neuroscience Education

June 21, 2021 - An author of a meta-analysis was interviewed about the efficiency of therapeutic pain education in various formats. (Source: Pain Medicine News)

Man Discusses Receiving Investigational Neurostimulation for Treatment-Resistant Addiction

June 18, 2021 - A news feature profiles a participant in a U.S. clinical trial of deep brain stimulation for opioid-use disorder. (Source: Washington Post)

Clinical Trial to Address Post-Treatment Cognitive Outcomes in Adult Survivors of Childhood Leukemia

June 18, 2021 - Clinicians are recruiting participants for a clinical trial of transcranial direct current stimulation to improve cognitive outcomes, such as executive functioning, in adult survivors of acute lymphoblastic leukemia. (Source: Cancer Therapy Advisor)

Company Announces Partnership with University for Noninvasive Peripheral Nerve Stimulation Therapies

June 17, 2021 - Cala Health, Inc. announced a partnership with the University of California, San Francisco to develop noninvasive peripheral nerve stimulation therapies. The announcement said the partnership builds on the recent launch of the company's transcutaneous stimulation therapy for hand tremors and integration of a data science platform. (Source: Business Wire)

Company Announces FDA Clearance for Noninvasive System for Chronic Pain

June 17, 2021 - NeuraLace Medical Inc. announced it has received FDA clearance for its noninvasive Axon Therapy for chronic nerve pain, which uses electromagnetic induction. (Source: PR Newswire)

Publication Reports Study of Vagus Nerve Stimulation in Stroke Rehabilitation

June 16, 2021 - An article summarizes a study in Lancet about vagus nerve stimulation combined with rehabilitation to improve arm function after stroke. (Source: Neurology Advisor)

Article Notes Neurostimulation Options for Acute Migraine Relief

June 16, 2021 - An overview of acute treatments for migraine includes neurostimulation methods, such as remote electrical neuromodulation, transcranial magnetic stimulation and noninvasive vagus nerve stimulation. (Source: Healio)

Review Summarizes Evidence for Peripheral Nerve Stimulation in Facial Pain Syndrome

June 15, 2021 - An article summarizes a journal article in Neuromodulation on peripheral nerve stimulation in trigeminal neuropathic pain. (Source: Clinical Pain Advisor)

Company Receives Clearance for Clinical Trial

June 15, 2021 - The FDA has granted LivaNova PLC an investigational device exemption for its clinical study of hypoglossal nerve stimulation in adults with moderate to severe obstructive sleep apnea. (Source: Business Wire)

Funding Announced for Project to Develop an Implantable Treatment to Aid Memory in Brain-Damaged Patients

June 15, 2021 - A multi-site $3.4 million project funded by the U.S. Army Medical Research and Development Command will focus on developing a prototype implantable device intended to treat memory loss in individuals with traumatic brain injury or neurological disease. (Source: University of Pennsylvania Almanac)

Company Announces Study in a Rare Form of Cognitive Decline

June 14, 2021 - Cognito Therapeutics announced it is beginning a study to evaluate its noninvasive visual and auditory stimulation technology in a rare condition associated with cognitive decline, Down syndrome associated Alzheimer's disease. (Source: Valdostsa Daily Times)

Company Announces Neurostimulator Approval

June 11, 2021 - Medtronic announced the FDA has approved its recharge-free neurostimulator for spinal cord stimulation, Vanta. (Source: Becker's Spine Review)

Noninvasive Neurostimulation Cognitive Effect Studied

June 10, 2021 - A recently published study explored the effect of cervical transcutaneous vagal nerve stimulation on cognitive performance during a state of sleep deprivation. (Source: Technology Networks)

Neurostimulator Company Files for Initial Public Offering

June 7, 2021 - CVRx filed paperwork to hold an initial public offering to raise up to $75 million to further commercialize its neurostimulator for heart failure. (Source: Mass Device)

Review Analyzes Infectious Complications of Dorsal Root Ganglion Stimulation Therapy

June 6, 2021 - A systemic review analyzes the incidence of infectious complications from the trialling and implantation of dorsal root ganglion stimulation systems. (Source: Neuromodulation: Technology at the Neural Interface)

One-Year Results Reported of Deep Brain Stimulation for Treatment-Resistant Obsessive Compulsive Disorder

May 2021 - Clinicians report a 1-year follow-up on a series of 11 patients with refractory obsessive-compulsive disorder who received deep brain stimulation to the bed nucleus of stria terminalis. (Source: World Neurosurgery)

Editorial Proposes Adopting a New Term for a Common Back Pain Condition

June 8, 2021 - In an editorial, clinicians explain support for retiring the term "failed back surgery syndrome" in favor of the proposed phrase "persistent spinal pain syndrome". (Source: Journal of Pain Research)

Study Explores Peripheral Nerve Stimulation for Recurrent Back Pain

June 8, 2021 - A recent prospective study examined the feasibility of targeted peripheral nerve stimulation of lumbar medial branch in participants whose chronic axial pain had returned after radio-frequency ablation. (Source: Pain Medicine News)

Company's Deep Brain Stimulation Leads Receive FDA Approval

June 7, 2021 - The FDA has approved Medtronic's SenSight directional lead system for use in deep brain stimulation therapy. (Source: Mass Device)

Brain-Computer Interface Company Receives $40 Million in Series B Financing

June 3, 2021 - Synchron, Inc. has raised $40 million in series B financing, which will be used to help launch a pivotal clinical trial in the U.S. of its intravascular brain-computer interface for patients with paralyzed limbs to use digital devices. (Source: Business Wire)

Obstructive Sleep Apnea Neurostimulator Trial Reaches Primary Endpoints

June 7, 2021 - Nyxoah SA announced a clinical trial of its hypoglossal nerve stimulation system for obstructive sleep apnea reached primary safety and performance endpoints. (Source: BioSpace)

A Retrospective Review Compares Skin Closure Techniques and Post-Procedure Pain in Patients Receiving Spinal Cord Stimulation Implants

June 4, 2021 - A retrospective review of 155 patients who were implanted with a spinal cord stimulator or dorsal root ganglion stimulator between 2017 and 2019 compared post-procedural pain in patients who received either a running suture closure or surgical staple closure. (Source: Pain Research and Management)

Retinal Implant Company's European Clinical Trial Proceeds, and U.S. Plans Are Under Exploration

June 2, 2021 - Pixium Vision announced the first patient has been implanted with its sub-retinal implant in a European clinical trial, and the company is exploring possible posting on NASDAQ to access U.S. markets. (Source: Globe Newswire)

Clinicians Report on 15 Years of Deep Brain Stimulation Therapy in Parkinson's Disease

June 2, 2021 - A retrospective study in Grenoble reports on treatment for 15 years or more of Parkinson's disease patients with deep brain stimulation systems that target the subthalamic nucleus. (Source: MedPage Today)

Researchers Study Vagus Nerve Stimulation Effect on Freezing of Gait in Parkinson's Disease

June 2, 2021 - The company electroCore announced publication of a paper about vagus nerve stimulation in Parkinson's disease patients who have freezing of gait. The randomized, double-blind, sham-controlled crossover trial took place at the Institute of Neurosciences in Kolkata, India in collaboration with medical sciences faculty at Newcastle University in England. (Source: StreetInsider)

Brain-Computer Interface Receives CE Mark

June 1, 2021 - The Wyss Center has earned CE mark certification for a brain-computer interface software platform that runs an auditory feedback speller, which prompts a user to select letters when forming words and letters on a graphical interface. The software, NeuroKey, is currently being used in a home-based study by a patient with amyotrophic lateral sclerosis. (Source: FDA News)

Column: Centers for Medicare and Medicaid Services and FDA-Approved Neuromodulation Therapies

June 1, 2021 - A column discusses the state of U.S. Medicare reimbursement policy pertaining to neuromodulation therapy. (Source: Neurotech Reports)

Authors Summarize Evidence about Neuromodulation for Chronic Pain

May 29, 2021 - An article summarizes levels of evidence for neuromodulation therapies for chronic pain, spanning electrical nerve stimulation (implanted or external) and transcranial magnetic stimulation. (Source: The Lancet)

Center Provides Multiple Sclerosis Patients Noninvasive Brain Stimulation at Home

May 28, 2021 - An academic center is offering at-home transcranial direct current stimulation therapy for cognitive, motor, speech, or mood symptoms associated with multiple sclerosis. (Source: Multiple Sclerosis News Today)

Research Explores Vagus Nerve Stimulation in COVID-19

May 27, 2021 - An article discusses research into vagus nerve stimulation as a potential adjunct therapy for COVID-19. (Source: News-medical.net)

Facility Uses Neurostimulation for Symptoms of Withdrawal

May 26, 2021 - A residential treatment facility has used transcutaneous auricular nerve stimulation to manage symptoms associated with opioid withdrawal. (Source: Globe Newswire)

Article Reports Results of Clinical Trial of Directional Deep Brain Stimulation in Parkinson's Disease

May 27, 2021 - Clinicians published the results of a randomized, double-blind crossover study of directional deep brain stimulation in Parkinson's disease. (Source: Neuromodulation: Technology at the Neural Interface)

Institute Funds U.K. Clinical Trial of Noninvasive Neurostimulation in ADHD

May 27, 2021 - A multi-center research team led by a professor at Kings College London has received £1,884,882.42 from the National Institute for Health Research to carry out a sham-controlled, blinded clinical trial of external trigeminal nerve stimulation in up to 150 children aged 8 - 18, who have attention deficit hyperactivity disorder. (Source: Mirage News)

Clinical Trial Starts of Magnetic Peripheral Nerve Stimulation for Neuropathic Pain

May 27, 2021 - NeuraLace Medical, Inc. announced the start of a randomized, controlled clinical trial of pulsed magnetic peripheral nerve stimulation to treat post-traumatic peripheral neuropathic pain. The stimulation is delivered by the company's Axon therapy coil. (Source: PR Newswire)

Brain-Stimulation Memory Device Development Receives $1 Million in Cooperative Research Funding

May 27, 2021 - Nia Therapeutics announced A $1 million cooperative agreement with the University of Pennsylvania to complete development of its closed-loop brain stimulation system to address memory issues in people who have brain injury or a neurodegenerative disease. The funding is sponsored by the U.S. Army Medical Research and Development Command, through its Medical Technology Enterprise Consortium. (Source: Medium)

Neurostimulator Receives Breakthrough Designation for Cluster Headache

May 25, 2021 - Unity HA announced it sphenopalatine ganglion stimulator received breakthrough device designation from the FDA for the treatment of acute pain associated with chronic cluster headaches. (Source: PR Newswire)

Researchers Seek to Predict Optimal Deep Brain Stimulation Parameters

May 24, 2021 - Researchers used fMRI and machine learning to try to predict optimal deep brain stimulation settings when programming DBS systems in patients with Parkinson's disease. (Source: Nature Communications)

Scientific Presentation Covers Personalized Neuromodulation Approach in Acute Depression

May 24, 2021 - A presentation at the 2021 American Psychiatric Association annual meeting discussed the potential for use of accelerated theta burst repetitive transcranial magnetic stimulation therapy in acute depression. (Source: Psychiatry & Behavioral Learning Network)

Data Presented from a Clinical Trial of Neurostimulation in Chronic Mechanical Low Back Pain

May 25, 2021 - A late-breaking plenary session of the 2021 virtual meeting of the North American Neuromodulation Society covered data from a clinical trial of neurostimulation in patients with refractory chronic mechanical low back pain. (Source: Pain Medicine News)

Neuromodulation Devices Receive Recognition in an Industry Design Competition

May 25, 2021 - Neurostimulation device maker Nalu Medical, Inc. announced its micro-implantable pulse generator was recognized during the 2021 Medical Design Excellence Awards as a gold-award winner in the Implant and Tissue-Replacement Device category. Also recognized in the 2021 awards was Theranica's Nerivio migraine device, which received a silver award in the category of Digital Health Products and Mobile Medical Apps. (Source: PR Web)

Researchers Present Data on Peripheral Nerve Stimulation for Post-Amputation Pain

May 21, 2021 - In a scientific meeting presentation, physicians presented comparative data on pain control from either eight weeks of peripheral nerve stimulation with standard medical therapy vs. standard medical therapy alone, in a group of 16 veterans who had had leg amputation. (Source: Healio)

Study Provides Data on Low Amplitude Settings for Sacral Nerve Stimulation

May 21, 2021 - A study examined the efficacy of sub-sensory amplitude settings for sacral neuromodulation in women with overactive bladder. (Source: Urology Times)

Clinical Trial Data Presented Concerning Neurostimulation for Symptoms of Opioid Withdrawal

May 21, 2021 - Data from a randomized controlled trial concerning noninvasive neurostimulation for opioid withdrawal symptoms were presented at a late-breaking plenary session of the 2021 virtual meeting of the North American Neuromodulation Society. The study evaluated the effect of transcutaneous transuricular neurostimulation in reducing symptoms of opioid withdrawal. (Source: Pain Medicine News)

Study Focuses on "Neural Dosing" Options for Sub-Perception Spinal Cord Stimulation

May 20, 2021 - An article summarizes a study published in Neuromodulation: Technology at the Neural Interface of high and low frequency options for sub-perception spinal cord stimulation. (Source: NeuroNews)

Researchers Report on a Prosthetic Limb that Provides a Sense of Touch

May 20, 2021 - Researchers published in Science about adding a sense of touch to a robotic limb controlled by a brain-machine interface. (Source: Northern Public Radio)

Brain-Computer Component Maker Receives Venture Financing

May 19, 2021 - Blackrock Neurotech has received a $10 million round of venture financing, which the company said will help it accept additional contracts that it has been being offered. (Source: CNBC)

Company Receives CE Marking for Sacral Neuromodulator

May 18, 2021 - Axonics Modulation Technologies announced CE mark approval for its second-generation sacral nerve stimulator and wireless patient controller. (Source: Mass Device)

Company Pursues Noninvasive Vestibular Stimulation Device

May 18, 2021 - A business announcement described PROTXX's wearable, dry-electrode, device, Neurvesta, that is initially focused on electrical vestibular stimulation to augment loss of motion-sensing cells due to aging or head impacts. (Source: EIN Presswire)

Company Announces CE Marking for Stretchable Brain-Surface Electrode

May 18, 2021 - WISE Srl announced CE marking of its cortical strip for brain monitoring, which can stimulate and record brain activity. (Source: BusinessWire)

Five-Year Data Published on Central Sleep Apnea Neurostimulation Therapy

May 17, 2021 - ZOLL Medical Corporation announced publication of five-year, post-approval, data on safety and efficacy of transvenous phrenic nerve stimulation for the treatment of moderate to severe central sleep apnea. The technology was developed by Respicardia, Inc., which Zoll acquired in April 2021. (Source: BusinessWire)

Data Presented on Neurostimulation Therapy for Medication-Resistant Hypertension

May 17, 2021 - Orchestra BioMed, Inc. presented interim two-year data from a European randomized controlled study of the company's autonomic nervous system stimulator in patients with persistent hypertension. The data were presented May 15, 2021 at the virtual American College of Cardiology meeting. (Source: Globe Newswire)

Researcher at the University of Washington is Recruiting Patients for Overactive Bladder Studies

May 17, 2021 - Three different urinary incontinence devices are being trialled in women at the University of Washington. Two of the devices stimulate either nerves in the ankle or lower back, and each use external batteries. The third device being studied is self-contained and inserted vaginally. (Source: Newswise)

Company Nets Over $200 Million in Initial Public Offering

May 14, 2021 - Axonics, Inc. gained $201.3 million in its initial public offering. The total included proceeds from underwriters' exercise of purchase options. (Source: Mass Device)

Agency Cautions Against Placing Mobile Devices with Strong Magnets Near Medical Devices

May 14, 2021 - The FDA issued a warning letter that people should keep at least six inches between any cell phone or smart watch with a high-strength magnet and electronic medical devices, particularly heart defibrillators, which monitor heart rate. Certain devices have a magnet mode for procedures such as MRI scans, which temporarily suspends normal operations when in proximity to the magnet. (Source: Medtech Dive)

Study Summarizes Patient Perceptions of Therapeutic Brain Stimulation

May 14, 2021 - In a systemic review of patient perceptions of noninvasive brain stimulation, authors found four studies assessed perceptions of repetitive transcranial brain stimulation in psychiatric patients. (Source: NeuroNews)

Review Assessed Noninvasive Brain Stimulation in Migraine

April 27, 2021 - A review analyzed randomized controlled trials of transcranial direct current stimulation used repeatedly for longer than four weeks. The authors performed a meta-analysis on its efficacy. (Source: Journal of Pain Research)

Researchers Report on a "Mindwriting" Brain Interface in a Paralyzed Study Subject

May 12, 2021 - Researchers describe development of an intracortical brain-computer interface that decodes attempted handwriting from neural activity in the motor cortex and translates it into text in real time. (Source: Nature)

Company Announces CE Mark for Chronic Migraine Treatment

May 12, 2021 - Swedish medical technology company Chordate Medical Holding AB announced its neuromodulation treatment for chronic migraine has received a CE mark. The treatment is undergoing clinical study in Germany and Finland, and previously was cleared in Europe for chronic rhinitis. (Source: Med-Tech Innovation News)

Neurostimulation Device Company Eyes a $150 Million Initial Public Offering

May 11, 2021 - Axonics, Inc. announced it has begun a proposed public offering of $150 million in shares of its common stock. The company said it will use proceeds to retire debt and commercialize its neuromodulation products in the U.S. and abroad. (Source: Mass Device)

Company Announces Publication of a 24-Month Spinal Cord Stimulation Study

May 10, 2021 - Saluda Medical announced publication of 24-month results from the prospective, multicenter, open-label Avalon Study of its closed-loop spinal cord stimulation system for chronic pain. (Source: PR Newswire)

Company Creates Spinal Cord Stimulation App

May 6, 2021 - Medtronic released a mobile app for patients receiving spinal cord stimulation therapy. (Source: Spinal News International)

Study: Noninvasive Pain Stimulation for Arthritis Knee Pain

April 30, 2021 - A small open-label feasibility study explored transcranial direct current stimulation for pain relief in patients who have knee osteoarthritis. (Source: Medscape)

Grant Supports Development of Device for Rehabilitation from Spinal Cord Injury

May 4, 2021 - BioCircuit Technologies announced a $4.6 million award from the National Institutes of Health to develop a noninvasive device to condition spinal reflexes during rehabilitation from partial spinal cord injury. The award will be shared with partnering laboratories at the Medical University of South Carolina and the National Center for Adaptive Neurotechnologies at the Stratton VA Medical Center in Albany, NY. (Source: Globe Newswire)

Retrospective Review Reports on Noninvasive Stimulation for Ocular Pain

May 4, 2021 - Clinicians reported a retrospective review of 18 patients of the Miami Veteran Affairs Eye Clinic who received trigeminal nerve stimulation at home for at least three months to address severe ocular pain. (Source: Neuromodulation: Technology at the Neural Interface)

Feasibility Trial Will Investigate Implantable Tibial Nerve Stimulation in Bladder Incontinence

April 27, 2021 - Medtronic announced FDA approval to launch a 12-month feasibility trial of an implantable tibial neuromodulation device in up to 20 patients who have bladder incontinence. (Source: PR Newswire)

Startup Raises $17.5 Million for Noninvasive Brain Stimulation Development

May 4, 2021 - Neuroelectrics announced raising $17.5 million in Series A financing that it said it will use to develop its noninvasive transcranial electrical stimulation platform and pursue clinical trials in focal epilepsy and refractory depression. (Source: BioSpace)

Team Wirelessly Monitors Parkinson's Disease Patients' Brain Activity

May 4, 2021 - A research team published its early development of a way to wirelessly record brain activity in Parkinson's disease patients for several hours at a time while they go about their everyday life. (Source: Gizmodo)

Review: Quality of Evidence and Clinical Effects of Auricular Vagus Neuromodulation

April 30, 2021 - A review of auricular vagus nerve stimulation randomized controlled trials indicated preliminary results concerning pathological vs. evoked pain. The review suggests improvements to reporting results and future directions, such as direct measures of neural target engagement and evaluation of blinding success. (Source: Frontiers of Neuroscience)

Study: Human Use of Wireless Implanted Brain-Computer Interface

April 28, 2021 - Researchers with the BrainGate Consortium reported the first human use of a high-bandwidth, wireless brain-computer interface. (Source: Ars Technica)

Wearables Added to Depression Trial

April 26, 2021 - LivaNova and Verily have enrolled the first patient in a sub-study, Uncover, that will use wearables to assess response to vagus nerve stimulation for depression as part of its Recover clinical trial. (Source: MD+DI)

Noninvasive Brain Stimulation Protocol Approved

April 26, 2021 - BrainsWay Ltd. announced FDA clearance of a three-minute treatment protocol with its deep transcranial magnetic stimulation system for the treatment of major depressive disorder. (Source: BioWorld)

Study Explores New Stimulation Mode for Movement Disorder

April 26, 2021 - A small crossover study explored the safety and tolerability of burst-cycling deep brain stimulation for freezing of gait in Parkinson's disease. (Source: Frontiers in Human Neuroscience)

Device for Stroke Rehabilitation Gets FDA Nod

April 23, 2021 - The FDA announced de novo authorization of Neurolutions' noninvasive brain-computer interface meant to improve grasping in patients undergoing rehabilitation for stroke. (Source: Medical Design & Outsourcing)

Brain Implants from a Patient's Perspective

April 19, 2021 - A feature article talks about the development of brain implants from the point of view of clinical trial participants and covers academic interest in such experiences, including "how a person’s selfhood can affect—and be affected by—an intelligent neural device." (Source: New Yorker)

Study Explores New Stimulation Mode for Movement Disorder

April 26, 2021 - A small crossover study explored the safety and tolerability of burst-cycling deep brain stimulation for freezing of gait in Parkinson's disease. (Source: Frontiers in Human Neuroscience)

Device for Stroke Rehabilitation Gets FDA Nod

April 23, 2021 - The FDA announced de novo authorization of Neurolutions' noninvasive brain-computer interface meant to improve grasping in patients undergoing rehabilitation for stroke. (Source: Medical Design & Outsourcing)

Brain Implants from a Patient's Perspective

April 19, 2021 - A feature article talks about the development of brain implants from the point of view of clinical trial participants and covers academic interest in such experiences, including "how a person’s selfhood can affect—and be affected by—an intelligent neural device." (Source: New Yorker)

Pivotal Study: Vagus Nerve Stimulation Paired with Rehabilitation After Stroke

April 24, 2021 - Results were reported in a pivotal randomized controlled trial of vagus nerve stimulation paired with physical rehabilitation in 106 patients who had moderate to severe arm weakness after ischemic stroke. (Source: The Lancet)

Neurostimulation Device Company's Initial Public Offering Raises $102 Million

April 22, 2021 - NeuroPace raised $102 million in the first full day of an initial public offering that was initially anticipated in SEC filings to raise $75 million. The proceeds will be used for commercialization of its RNS system, R&D, clinical studies, and repayment of about $4 million from a Paycheck Protection Program loan. (Source: MassDevice)

Researchers Present Comparative Patient Data for Two Brain Stimulation Targets in Parkinson's Disease

April 21, 2021 - A presentation covered comparative outcomes in Parkinson's disease patients of deep brain stimulation to either the subthalmic nucleus or the globus pallidus. Patients were followed for up to 10 years. (Source: AJMC Managed Markets Network)

Meeting Proceedings Cover Updates in Emerging Technologies and Therapies for Deep Brain Stimulation

April 19, 2021 - Proceedings of the 8th annual Deep Brain Stimulation Think Tank, held virtually in September 2020, were published. The meeting covered updates in neurotechnology and neuromodulation. (Source: Frontiers in Human Neuroscience)

Data Reported in Pilot Trial of Peripheral Nerve Stimulation in Postoperative Pain

April 15, 2021 - A pilot study assessed acute postoperative pain and opioid consumption in patients who received percutaneous peripheral nerve stimulation, compared to sham treatment. (Source: EurekAlert)

Pilot Trial Starts of Neuromodulation Device for Heart Failure

April 15, 2021 - Cardionomic, Inc. announced initial enrollment in Panama in a worldwide pilot study of its Cardionomic Pulmonary Neuromodulation System. The endovascular device stimulates the sympathetic nervous system via the pulmonary artery. The approach is based on early studies in which the stimulation increased cardiac contractility in chronic heart failure patients without significantly changing heart rate. (Source: SouthernMinn.com)

U.S. Medicare to Require Prior Authorization for Spinal Cord Stimulation

April 14, 2021 - Beginning July 1, the Centers for Medicare and Medicaid Services will require prior authorization for cervical fusion with disc removal and implanted spinal neurostimulators. (Source: Becker's Spine Review)

Researchers Assess Disparities in Access to Neuromodulation

April 14, 2021 - Researchers presented findings from a review of literature and surveys about disparities in access to neuromodulation therapy for women and underrepresented minorities. (Source: NeuroNews International)

Clinical Trial Starts of Spinal Cord Stimulation in Low Back Pain

April 14, 2021 - An article says a clinical trial, DISTINCT (Dorsal spInal cord STImulatioN vs mediCal management for the Treatment of low back pain), will begin in Nevada that compares spinal cord stimulation for pain to standard medical care. (Source: Las Vegas Review-Journal)

Evolution in Peripheral Nerve Stimulation for Pain

April 14, 2021 - An interview covers developments in peripheral nerve stimulation for pain. (Source: Pain Medicine News)

Patients from United Arab Emirates Start Using Abu Dhabi Facility to Receive Deep Brain Stimulation for Parkinson's Disease

April 13, 2021 - The first Parkinson's disease patients from the United Arab Emirates received deep brain stimulation implants in Abu Dhabi, where the service started last year. (Source: Gulf News)

Case Series Reports Outcomes in Pain Patients Following Peripheral Neurostimulation, With or Without a Preceding Trial

April 12, 2021 - A journal article details a retrospective case series of 72 patients who were treated with peripheral nerve stimulation (PNS) for chronic pain, 59 of whom received a preceding PNS trial. (Source: MD Linx)

Researchers Investigate the Effect of Occipital Neurstimulation on Putative Sensitization Factor in Migraineurs

April 12, 2021 - A small study compared aversive response to peripheral irritation with, and without, active occipital nerve stimulation in patients who have chronic migraine. The researchers suggest decreasing the effect of trigger factors might reduce central nervous system sensitization. (Source: Clinical Pain Advisor)

Corporation Acquires Manufacturer of Neurostimulation Implant for Heart Patients with Sleep Condition

April 12, 2021 - Zoll Medical Corporation has acquired Respicardia, Inc., and its implantable neurostimulators for the treatment of central sleep apnea in adults with reduced cardiac function. (Source: Business Wire)

Study: Neurostimulation in Patients with Refractory Overactive Bladder, from 2006 to 2019

April 11, 2021 - A publication reports findings in a study of sacral neuromodulation in 263 individuals with overactive bladder, including outcomes in patients who had failed botulinum toxin, compared with patients who had not received it. (Source: MD Linx)

Data Published on Noninvasive Neurostimulation in Pediatric Cerebral Palsy Patients

April 11, 2021 - A journal reports on combining transcranial pulsed current stimulation and transcutaneous electrical nerve stimulation to address lower limb spasticity in children with cerebral palsy. (Source: Medical Dialogues)

Technology Company Works on Wireless Brain-Computer Interface

April 9, 2021 - Neuralink posted a video of a macaque monkey using a video game controller through a wireless brain-computer interface under development by the company, which said its work builds on prior research. Coverage of the development referred to earlier work on brain-computer interface development in individuals with paralysis. (Source: Ars Technica)

Study Evaluated Noninvasive Vagus Nerve Stimulation in Hospitalized COVID-19 Patients

April 8, 2021 - Top-line results were released in a study designed to evaluate the safety and feasibility of noninvasive vagus nerve stimulation in addition to the current standard of care in patients hospitalized with active SARS-CoV-2 infection. (Source: Street Insider)

Potential Directions for Dorsal Root Ganglion Stimulation

April 7, 2021 - An interview discusses dorsal root ganglion stimulation for pain. (Source: Pain Medicine News)

Clinicians Report on Deep Brain Stimulation in Obsessive Compulsive Disorder

March 29, 2021 - A paper presents findings from a study of deep brain stimulation that targeted the bed nucleus of the stria terminalis in nine patients with treatment-resistant obsessive compulsive disorder. (Source: Translational Psychiatry)

Noninvasive Brain Stimulation Treatment for Depression in Patients with History of Childhood Trauma

March 29, 2021 - A presentation summarized findings in patients with certain types of childhood trauma and their response to transcranial magnetic stimulation for depression. (Source: Psychiatry & Behavioral Health Learning Network)

Study: Closed-Loop Spinal Cord Stimulation in Pain Patients

March 26, 2021 - Final 24-month results were published in the Avalon study of closed-loop spinal cord stimulation in chronic pain patients. (Source: Pain Practice)

Study Investigates Treatment of Painful Diabetic Neuropathy with Spinal Cord Stimulation

April 5, 2021 - A randomized clinical trial compared 10 kHz spinal cord stimulation with conventional medical management in patients with medically refractory painful diabetic neuropathy. (Source: JAMA Neurology)

Review Considers Use of Functional Electrical Stimulation to Improve Gait After Stroke

April 2021 - A review was published to guide clinical decision-making about the use of ankle-foot orthosis or functional electrical stimulation after stroke . (Source: Journal of Neurologic Physical Therapy)

In Merger, Device Company Becomes a Wholly Owned Subsidiary

March 30, 2021 - Bioventus Inc. has acquired the peripheral nerve stimulation device company Bioness, Inc. for $45 million up front, and $65 million in milestone contingency payments. (Source: Globe Newswire)

Researchers Study Noninvasive Brain Stimulation and Suicide Reduction in Depressed Patients with PTSD

April 1, 2021 - An article summarizes a study published in Neuromodulation that investigated multimodal elements of suicidality reduction after transcranial magnetic stimulation in patients with PTSD and depression. (Source: NeuroNews)

Company Receives Breakthrough Designation for Noninvasive Neurostimulation Device

March 23, 2021 - EncoraTherapeucs announced FDA Breakthrough Device designation for its tremor-reduction wearable device. (Source: Encora)

Company Announces Breakthrough Device Designation

March 31, 2021 - Neuropace, Inc. announced Breakthrough Device designation from the FDA for the potential use of its RNS system to treat idiopathic generalized epilepsy. (Source: Street Insider)

Article Addresses Choices of Neurostimulation Targets for Chronic Pain

March 31, 2021 - An interview covers when to choose neurostimulation other than spinal cord stimulation. (Source: Pain Medicine News)

Company Developing Graphene Brain Interface Announces $17 Million in Funding

March 30, 2021 - Spain-based INBRAIN Neuroelectronics S.L., founded in 2019 and working on medical device therapy for epilepsy and Parkinson's disease, announced $16.8 million in Series A funding. The funding will be used in its clinical research program concerning graphene-based electrodes. (Source: BioSpace)

Company Announces Expanded Service Life of Neurostimulation Component

March 25, 2021 - Nalu Medical's micro-implantable pulse generator has received FDA clearance for an expanded service life of 18 years. (Source: Yahoo Finance)

Neurostimulator Gains FDA De Novo Device Approval

March 30, 2021 - The FDA has given Helius Medical’s Portable Neuromodulation Stimulator approval for short-term treatment of gait deficit due to multiple sclerosis. (Source: FDA News)

U.S. Medical Center Adds Remote Programming for Deep Brain Stimulation Systems

March 29, 2021 - Rush University Medical Center in Chicago began offering a telemedicine video chat to remotely adjust treatment settings on deep brain stimulation systems. (Source: Newswise)

Practitioners Discuss Neurostimulation for Chronic Pelvic Pain

March 24, 2021 - Brief interviews of pain management physicians focus on newer research into neurostimulation for chronic pelvic pain. (Source: Pain Medicine News)

Clinicians Report Experience with Remote Spinal Cord Stimulation Programming

March 22, 2021 - An article in Neuromodulation describes the use of remote programming for spinal cord stimulations in patients with chronic pain during the COVID-19 outbreak in China. (Source: DocWire News)

Company Announces CE Mark Approval for Neurostimulator Component

March 22, 2021 - Medtronic announced CE mark approval for its SenSight directional lead system for deep brain stimulation. (Source: Mass Device)

Company Announces CE Mark Approval for Neurostimulator Component

March 22, 2021 - Medtronic announced CE mark approval for its SenSight directional lead system for deep brain stimulation. (Source: Mass Device)

Interview Discusses Brain Stimulation Technologies' Effect on Memory

March 20, 2021 - A radio interview talks about research into effects of noninvasive brain stimulation on memory, and the potential to help improve conditions like Alzheimer's disease and dementia. (Source: KCRW)

Patient is First in Arkansas to Receive Deep Brain Stimulation for Epilepsy

March 19, 2021 - The first deep brain stimulation surgery for epilepsy was conducted in Arkansas in a patient who had been using vagus nerve stimulation for the condition. (Source: UAMS News)

Lung-Pacing Company Receives Breakthrough Device Designation

March 18, 2021 - The privately held startup Stimdia Medical Inc. announced Breakthrough Device Designation from the U.S. FDA for its neurostimulator to aid in weaning patients from mechanical ventilation. (Source: Odessa American)

Company Announces Updated Spinal Cord Stimulator Labeling

March 17, 2021 - Medtronic announced the FDA approved updated device labeling to include study outcomes from a multicenter randomized control trial. (Source: PR Newswire)

Researchers Investigate Spinal Cord Stimulation in Painful Peripheral Neuropathy

March 17, 2021 - An interview covers research into spinal cord stimulation for painful peripheral neuropathy. (Source: Pain Medicine News)

Study: Data Show Disparities in Treatment with Neurostimulation for Pain

March 16, 2021 - Research published in Neuromodulation is summarized concerning an investigation into racial and socioeconomic disparities in spinal cord stimulation in patients who were covered by Medicare and/or Medicaid insurance.  (Source: Docwire News)

University Receives Grant to Develop Epidural Spinal Cord Stimulation for Spine-Injured Patients

March 15, 2021 - The National Institute of Neurological Disorders and Stroke has given the University of Louisville a $7.8-million grant under the U.S. Brain Initiative to develop and test software for adapting a commercially available spinal cord stimulation system for use in epidural spinal cord stimulation in individuals with spinal cord injury, to regain more motion and bladder control. (Source: News-Medical.net)

Newer Procedure OK'd by FDA in Neurostimulation for Obstructive Sleep Apnea

March 15, 2021 - Inspire Medical Systems, Inc. announced FDA approval of a simpler surgical implant procedure for its neurostimulation device for the treatment of obstructive sleep apnea. (Source: StreetInsider.com)

Study: Factors Influencing Uptake of Deep Brain Stimulation for Obsessive Compulsive Disorder

March 12, 2021 - In a single-institution retrospective chart review, authors sought to identify factors hindering obsessive compulsive patients from receiving deep brain stimulation therapy. (Source: Frontiers in Surgery)

Review: Sacral Neuromodulation in Neurogenic Lower Urinary Tract Dysfunction

March 15, 2021 - A review and meta-analysis covers 20 years of scientific literature concerning safety and effectiveness of sacral nerve stimulation in neurogenic lower urinary tract dysfunctions. (Source: Physicians Weekly)

Review: Peripheral Neurostimulation's Proposed Pain-Relief Mechanisms

March 12, 2021- A review presents a proposed mechanism for pain relief from percutaneous peripheral nerve stimulation. (Source: Journal of Pain Research)

Deep Brain Stimulation Service to Be Established in Dublin, Ireland

March 11, 2021 - A functional neurosurgeon is establishing the first deep brain stimulation service in Dublin, Ireland, where patients previously had to travel to Belfast or the UK for the surgery. Some 40 patients are expected to begin receiving the implantation procedures in the late summer. (Source: Athlone Advertiser)

Trial Investigates Shorter Protocol for Minimally Invasive Neurostimulation Treatment of Overactive Bladder

March 11, 2021 - A prospective, randomized, sham-controlled trial studied comparative efficacy of a shortened treatment period of overactive bladder with percutaneous tibial nerve stimulation. The shortened period was 6 weeks, rather than the usual 12 weeks, and study participants received either active stimulation or sham during that time. (Source: Medical Dialogues)

Researchers Study Recruitment Issues in Clinical Trial of Deep Brain Stimulation for Depression

March 10, 2021 - Clinicians in Canada report on an analysis of challenges in recruiting patients with treatment-resistant depression for deep brain stimulation. (Source: Neuropsychiatric Disease and Treatment)

Interview Focuses on Spinal Cord Stimulation Modes

March 10, 2021 - An interview describes how multiple waveforms are increasing spinal cord stimulation options. (Source: Pain Medicine News)

Clinicians Share Radiation-Safety Practices and Knowledge

March 9, 2021 - A survey investigated radiation-safety practices and knowledge gaps among interventional pain treatment practitioners. (Source: Regional Anesthesia & Pain Medicine)

Researchers Report Data on Potential Biomarker for Personalized Neurostimulation in Parkinson's Disease

March 5, 2021 - As a potential biomarker of motor improvement during adaptive deep brain stimulation, clinicians assessed beta band activity in a Parkinson’s disease patient. (Source: European Journal of Neurology)

Study Compares Two Spinal Cord Stimulation Modes

March 9, 2021 - A study compared spinal cord stimulation in patients with axial back pain delivered at either at high frequency (10,000 Hz) or in 500 Hz burst mode. (Source: Pain Medicine News)

Article Considers Non-Opioid Intrathecal Pain Relief in a European Setting

March 9, 2021 - A review article discusses the Polyanalgesic Consensus Conference and potential for a set of European guidelines regarding use of ziconitide for intrathecal analgesia in Europe. (Source: Brain and Behavior)

Implanted Neurostimulator Launched in Australia for Chronic Low Back Pain

March 9, 2021 - Mainstay Medical launched an implantable neurostimulation system for chronic low back pain in Australia. (Source: Medical Device Network)

Company Announces Clinical Trial Data Concerning Neurostimulation in Alzheimer's Disease

March 9, 2021 - Cognito Therapeutics announced Phase 2 results of gamma frequency neuromodulation in Alzheimer's disease. (Source: Business Wire)

Neuromodulation Device Maker Updates App with Remote Programming

March 8, 2021 - Abbott announced it has updated its patient app, NeuroSphere, which allows remote communication and programming updates for deep brain stimulation or spinal cord stimulation therapy. (Source: MobiHealthNews)

Company Announces FDA Approval of Visual Prosthetic Components

March 5, 2021 - Second Sight Medical Products announced FDA approval of its Argus 2s Retinal Prosthesis System, consisting of ergonomically redesigned glasses and a more powerful video processing unit. The company said the system integrates with its implanted systems in patients with retinitis pigmentosa. (Source: Business Wire)

Research Paper Projects Potential Function of Retinal Implant

March 5,2021 - Scientists in Europe published a virtual reality program to simulate what patients who have retinitis pigmentosa might see with retinal implants they are developing. (Source: Neuroscience News)

Researchers Explore Potential Pain Modulation with Optogenetics

March 5, 2021 - Nanoscope Therapeutics, Inc. announced presentation of a paper about pain modulation using opsin-based neuromodulation therapy. (Source: Odessa American)

Article Describes Minimally Invasive Brain-Computer Interface

Feb. 28, 2021 - An article says a sensor implanted in a vein near the motor cortex "might just be the first intracranial brain-computer interface (BCI) designed for everyday home use, enabling paralysed patients to regain independence by controlling a laptop or mobile phone using their thoughts." (Source: Medium)

Article Highlights Advances in Treating Chronic Pain with Neuromodulation

March 5, 2021 - Neuromodulation therapy is featured in an article about the future of personal health and treatment of chronic pain. (Source: MediaPlanet)

Stroke Patient Works with Neurosurgeons to Control a Robotic Limb Brace

March 3, 2021 - Physicians at Jefferson University Medical Center are working with a stroke patient to try a brain-computer interface linked to a brace on his weakened left arm to restore more motor control over the limb. (Source: The Health Nexus)

Case Report Published of Obstructive Sleep Apnea Treatment

March 3, 2021 - Nyxoah SA announced publication of case from a study of its neurostimulator, descrbing the experience of a patient who had obstructive sleep apnea with complete concentric collapse. (Source: Globe Newswire)

ELITE Study Will Gather Post-Market Outcome Data for Rechargeable Sacral Nerve Stimulation System

March 3, 2021 - A post-market study of up to 200 patients at 40 centers will assess safety, performance, and long-term outcomes of the InterStim Micro system for sacral neuromodulation. (Source: Newswise)

Company Announces Upcoming Presentation Concerning Neurostimulation in Alzheimer's Disease

March 2, 2021 - Cognito Therapeutics announced clinical data will be presented in an online scientific meeting on March 12 about gamma frequency neuromodulation in Alzheimer's disease. (Source: Business Wire)

Noninvasive Stimulation Tested in Post-Infection Joint Pain

March 2, 2021 - In a sham-controlled randomized trial, clinicians analyzed the effect of alternate sessions of transcranial direct current stimulation on persistent joint pain. The study subjects were women who had been infected by the chikungunya virus. (Source: Brain Stimulation)

Sacral Nerve Stimulation Setting is Subject of Study

March 1, 2021 - A study evaluated the effect of sub-sensory amplitude settings in sacral nerve stimulation therapy for overactive bladder. (Source: Neurology Urodynamics)

Article Addresses Access to Spinal Cord Stimulation

March 3, 2021 - An interview covers some obstacles for pain patients to access spinal cord stimulation therapy. (Source Pain Medicine News)

Journal Article Summarizes Studies of a Neurostimulation Modality for Pain Conditions Beyond CRPS

March 2, 2021 - A systemic review in Neuromodulation summarized studies of dorsal root ganglion stimulation treatment for chronic pain beyond complex regional pain syndrome (CRPS). (Source: Clinical Pain Advisor)

Noninvasive Neurostimulator Receives FDA Clearance for Acute Migraine Pain

March 2, 2021 - The FDA issued clearance for a multichannel noninvasive brain stimulation device to treat acute migraine pain, Relivion from Neurolief. (Source: Medscape)

Report: Deep Brain Stimulation Operative Time Based on Imaging Method

March 2, 2021 - Authors present findings from a retrospective chart review about operative time based on stereotactic imaging types. The findings emanated from a quality assurance study performed at an institution that changed from a deep-brain-stimulation-surgery imaging technique of post-implantation MRI to in-room CT. (Source: Surgical Neurology International)

Clinicians Propose Formalizing Recommendations for Physical Activity Following a Device Implant

March 1, 2021 - A letter proposes creation of consensus recommendations for physical activity following implantation of a neuromodulation device. (Source: American Academy of Pain Medicine)

Company Announces Distribution Agreement

March 1, 2021 - The company electroCore announced an exclusive distribution agreement in Australia for its noninvasive vagus nerve stimulator. (Source: StreetInsider.com)

Podcast About Neurosurgery and Cognition Focuses on Chronic Pain

Feb. 28, 2021 - In an interview about pain neurosurgery, Dr. Julie Pilitsis refers to chronic pain as tri-dimensional, involving sensory, cognitive, and emotional elements, saying that patients need holistic treatment from a multidisciplinary approach. (Source: Neurosurgery Podcast)

Review: Image Guidance for Deep Brain Stimulation Surgery

Feb. 26, 2021 - A review provides image guidance on deep brain stimulation surgery to treat Parkinson's disease. (Source: TBME)

Neurostimulation Device Maker Acquires a Therapeutics Company

Feb. 26, 2021 - Sacral nerve stimulator device-maker Axonics Modulation Technologies has acquired the company Contura, which developed a recently FDA-approved urethral bulking agent for overactive bladder. (Source: Medtech Dive)

Researchers Study Noninvasive Brain Stimulation and Opioid Craving

Feb. 26, 2021 - A transcranial magnetic stimulation study examined two brain areas for potentially reducing craving for opioids. The study also explored participants' pain levels. (Source: New-medical.net)

Analysis Explores Deep Brain Stimulation and Mood in Parkinson's Disease Patients

Feb. 25, 2021 - A meta-analysis examines mood changes after bilateral subthalamic deep brain simulation in patients with Parkinson's disease. (Source: Physician Weekly)

Researchers Make Data Available in Study of Stimulation and Emotional Self-Regulation

Feb. 24, 2021 - Scientists released a dataset of fMRI data associated with neurofeedback, to support research into using stimulation to reinforce self-regulation. (Source: Study Finds)

Authors Track Continuance of Percutaneous Tibial Nerve Stimulation for Bladder Condition

Feb. 24, 2021 - A study assessed rates of drop-out from continued percutaneous tibial nerve stimulation treatment for overactive bladder, compared to compliance with medical management.  (Source: Renal and Neurology News)

Article Features Experience with Treatment by Spinal Cord Stimulation for Abdominal Issues

Feb. 23, 2021 - Clinicians published a retrospective chart review of 26 consecutive patients who underwent a spinal cord stimulation trial for a primary diagnosis of nausea, vomiting, and refractory pain. (Source: Digestive Diseases and Sciences)

Noninvasive Neurostimulation Clinical Trial Completes Enrollment in COVID-19 Patients

Feb. 24, 2021 - The company electroCore has completed enrollment in a controlled trial of external vagus nerve stimulation in 110 adults with respiratory failure due to SARS-CoV-2 infection. (Source: MD+DI)

Magazine Article Features the Potential Emergence of Personalized Brain Stimulation Therapies for Mental Health Issues

Feb. 24, 2021 - A magazine article refers to recent research in obsessive compulsive disorder, and discusses possibilities concerning personalized brain stimulation therapy for issues such as depression. (Source: New York Times Magazine)

Physician Discusses Minority Diversity Issues in Access to Pain Therapies

Feb. 22, 2021 - In a video interview, Dr. Stephanie Vanterpool describes "how outreach can be used to address the disparities between white and underrepresented minority patients when it comes to accessing neuromodulation therapies." (Source: NeuroNews)

Video Explains Spinal Cord Stimulation Frequencies and Patterns

Feb. 24, 2021 - Two pain physicians from U.S. academic medical centers are interviewed in a three-minute video where they describe different spinal cord stimulation waveforms and stimulation patterns. (Source: Pain Medicine News)

Study Will Track Patients Who Begin a New Spinal Cord Stimulation Program

Feb. 24, 2021 - Celéri Health announced enrollment of the first patient in a study of long-term outcomes in up to 1,700 participants at 30 U.S. centers who plan to begin spinal cord stimulation treatment with Medtronic's differential target multiplexed programming. (Source: Globe Newswire)

Registry Data Documents Transcranial Magnetic Stimulation Treatment for Depression

Feb. 23, 2021 - Neuronetics announced publication of data from a clinical registry of 5,010 patients who were treated with two different protocols involving transcranial magnetic stimulation for depression. A standard protocol took 38.5 minutes and a shorter one took 18.75 minutes. (Source: Globe Newswire)

Study Assesses Levodopa Challenge in Two Deep Brain Stimulation Targets for Motor Disorder

Feb. 23, 2021 - A retrospective study assessed the value of short-term response to levodopa in predicting motor outcomes of Parkinson's disease patients following deep brain stimulation that either targeted the globus pallidus interna or the subthalamic nucleus. The study looked at factors such as tremor and patient age. (Source: AJMC)

Company Announces Implantation of 4th-Generation Deep Brain Stimulation System

Feb. 23, 2021 - The first U.S. Parkinson's disease patient has been implanted with a fourth-generation deep brain stimulation system from Boston Scientific. (Source: Parkinson's News Today)

Italian Startup Announces CE Mark for Its Deep Brain Stimulation System

Feb. 23, 2021 - The Italian spin-out Newronika announced it has received CE Mark approval for its deep brain stimulation system, AlphaDBS. The rechargeable system has a sensing technology that is under clinical evaluation that records local field potentials during stimulation. (Source: PR Newswire)

Percutaneous Nerve Stimulation Trialled for Low Back Pain

Feb. 22, 2021 - Investigators report a prospective, multicenter clinical trial of percutaneous peripheral nerve stimulation of medial branch nerves for chronic low back pain following lumbar radiofrequency ablation. (Source: Pain Medicine)

Neurostimulation Device Maker Announces Financing Round

Feb. 17, 2021 - Mainstay Medical announced it has closed an equity financing worth gross proceeds of $108 million. (Source: Mass Device)

Expanded MRI-Conditional Labeling Announced for Sacral Neuromodulator

Feb. 18, 2021 - Expanded labeling was approved by the FDA  for Medtronic’s InterStim II and InterStim Micro sacral neuromodulation systems that use SureScan MRI leads. (Source: Healio Neurology)

Clinicians Look at Pre-Seizure Autonomic Nervous System Feature and Neurostimulation Response in Patients with Drug-Resistant Epilepsy

Feb. 18, 2021 - Investigators studied pre-seizure heart rate variability in epilepsy patients to see if that is correlated with response to vagus nerve stimulation therapy. (Source: European Journal of Epilepsy)

Neuroradiologist Considers Emerging Neuromodulation Techniques

Feb. 18, 2021 - An interview with a neuroradiology professor mentions potential future integration of neuromodulation and neurointervention for therapy applications. (Source: NeuroNews)

Sleep Disorder Researchers Report on Monitoring of Apnea Patients Who Have an Implanted Neurostimulator

Feb. 18, 2021 - An article summarizes a published case series about overnight pulse oximetry for titration of hypoglossal nerve simulation in patients with obstructive sleep apnea. (Source: Healio)

Article Sets Forth Patient-Selection Considerations Regarding Deep Brain Stimulation for Tourette Syndrome Patients

Feb. 16, 2021 - Clinicians present current principles of patient selection in deep brain stimulation for Tourette syndrome, and raise future considerations. (Source: Neurology)

Investigational Noninvasive Device for Stroke Recovery Receives Breakthrough Device Status

Feb. 11, 2021 - The Israeli startup BrainQ announced its investigational stroke recovery device, which delivers a frequency-tuned low intensity electromagnetic field, has received Breakthrough Device designation from the U.S. FDA. (Source: PR Newswire)

Meta-Analysis Explores a Cost-Effective Threshold for Emerging Parkinson's Disease Treatment

March 2021 - Based on articles from 1998 - 2018, a team of authors analyzed utility and cost-effectives of treatment procedures, including deep brain stimulation, for Parkinson's disease. (Source: Neurosurgery)

Noninvasive Neurostimulator Receives FDA Approval for Adolescent Migraineurs

Feb. 17, 2021 - The FDA expanded clearance of electroCore's noninvasive vagus nerve stimulator for acute and preventive treatment of migraine to include adolescents aged 12 - 17, in addition to adults. (Source: MPR)

FDA Approves a Third-Generation Sacral Nerve Stimulator

Feb. 17, 2021 - Axonics received supplemental premarket approval from the FDA for its third-generation neurostimulator to treat urinary and bowel dysfunction. (Source: FDA News)

Review Considers Range of Neurostimulation Options for Chronic Disabling Low Back Back

Feb. 17, 2021 - A review centers on management of chronic disabling low back pain and rapidly evolving neurostimulation options. (Source: Journal of Pain Research)

Practitioners Surveyed on Battery Life of Deep Brain Stimulation Devices

Jan. 26, 2021 - An article presents observations concerning trends in battery life of deep brain stimulation devices. (Source: Movement Disorders)

Interview Offers an Overview of the Development of Neuromodulation for Chronic Pain

Feb. 15, 2021 - A Q&A interview covers the evolution of neuromodulation therapy for chronic pain and possible directions in its further development and application, and considers the perspective of patients and providers. (Source: Pain Medicine News)

Company Announces Neuromodulation Research Funding

Feb. 15, 2021 - In a deal that provides researchers with opportunities to study neural biomarker technology, BIOS, a Cambridge, U.K. startup, announced $900,000 funding over 12 months from the U.S. National Institutes of Health's Stimulating Peripheral Activity to Relieve Conditions (SPARC) program; a potential second-year award could bring the total funding from SPARC to about $1.4 million. Source: Business Weekly)

Researchers Try 3D Model to Optimize Neurostimulation for Pain Patients

Feb. 8, 2021 - Researchers investigated creation of a patient-specific predictive model for programming coverage of tonic spinal cord stimulation, using on magnetic resonance imaging from two patients. (Source: Journal of Neural Engineering)

Implant Studied to Address Vestibular Balance Disorder

Feb. 11, 2021 - The New England Journal of Medicine published an early feasibility study of an implanted vestibular protheses in individuals with instability and vision issues based on loss of vestibular hair cell function. (Source: Medical Xpress)

Authors Report on Prevalence of Pelvic Floor Symptoms in Women with Parkinson's Disease

Feb. 11, 2021 - Physicians who surveyed women with Parkinson's disease and age-matched controls investigated the extent of self-reported pelvic floor symptoms, including any beyond what may have previously been reported to a healthcare provider. (Source: Journal of Parkinson's Disease)

Article Presents Data on Painkiller Consumption Following Neuromodulation Therapy

March 2021 - In a retrospective analysis, 67 patients who had a trial or permanent spinal cord stimulator were evaluated for changes in opioid consumption. (Source: Pain Management)

Clinical Trial Assesses Noninvasive Vagus Nerve Stimulation in Stroke

Feb. 2, 2021 - The company electroCore announced completion of a 68-person enrollment in a double-blind, randomized, sham-controlled, Phase 2 trial in Turkey to assess safety and feasibility of noninvasive vagus nerve stimulation as an acute method to decrease ischemic brain injury from stroke. (Source: BioSpace)

Company Announces FDA Conditional MRI Labeling

Feb. 9, 2021 - Nyxoah SA announced FDA approval for MRI conditional labeling of its hypoglossal nerve stimulation device, for obstructive sleep apnea, for full-body 1.5T and 3T diagnostic scans within approved parameters. (Source: Globe Newswire)

FDA Breakthrough Device Designation Announced for Neurostimulator Under Development for Migraine

Feb. 8, 2021 - Minnesota-based ShiraTronics, Inc. announced FDA breakthrough device designation for a neurostimulation device for chronic migraine. (Source: PR Newswire)

Study Investigates Minimally Invasive Neurostimulation for Urinary Symptoms in Parkinson's Disease Patients

Feb. 8, 2021 - An article summarizes a study of percutaneous posterior tibial nerve stimulation in 76 Parkinson's disease patients with detrusor activity, who underwent a tapering protocol over 24 months. (Source: MD Linx)

Noninvasive Brain Stimulation Device Company Announces Acquisition

Feb. 5, 2021 - Flow Neuroscience has acquired the assets of brain stimulation technology developer Halo Neuroscience pertaining to potential treatment of depression and other mental health disorders. (Source: Medical Device Network)

Company Announces Closed-Loop Deep Brain Stimulation Implantation

Feb. 4, 2021 - Newronika, which was spun out from Italian neurological research institutions, announced the first implantation of its adaptive closed-loop deep brain stimulation system, AphaDBS. (Source: PR Newswire)

Researchers Study Noninvasive Brain Stimulation and Memory

Feb. 4, 2021 - A study that used videos to prompt formation of memories about complex and realistic events evaluated the effect of transcranial magnetic stimulation on memory. (Source: Neuroscience News)

Article Presents Update on Access to Deep Brain Stimulation in British Columbia, Canada

Feb. 3, 2021 - An article says the British Columbia Ministry of Health is recruiting a second neurosurgeon to reduce waits for deep brain stimulation (DBS) surgery by Parkinson's disease patients, and that new equipment added in June 2019 has allowed the number of annual DBS surgeries to increase from 38 to 78. The article says improvements in access were advocated for by a patient who was able to receive a DBS system 17 months ago, two years after she was referred for the procedure to manage her Parkinson's disease. (Source: Salmon Arm Observer)

Company Announces Availability of a Neuromodulation Device Master File

Feb. 1, 2021 - Development partners will be able leverage platform technology that Cirtec Medical will make available in a Device Master File from intellectual property it obtained nine months ago from the FDA- and CE mark-approved Nuvectra Algovita Spinal Cord Stimulation System. The step follows a sponsor-initiated withdrawal of a premarket approval for the system. (Source: Cirtec Medical)

Study Reports Data on Noninvasive Brain Stimulation for Tinnitus

Jan. 30, 2021 - Researchers shared outcomes from a prospective longitudinal study of high-definition transcranial direct current stimulation in a large cohort of patients with tinnitus. (Source: Progress in Brain Research)

Paper Describes Noninvasive Neurostimulation Targeting Blood Pressure Regulation in Patients with Spinal Cord Injury

Jan. 28, 2021 - Collaborators in Switzerland and Canada published research in Nature about adapting epidural electrical stimulation of the spinal cord to control blood pressure after spinal injury. (Source: Expatica)

Review: Brain Stimulation Helps Shed Light on Obsessive Compulsive Disorder

Jan. 1, 2021 - A review focuses on research that could potentially shed light on the pathophysiology of obsessive compulsive disorder, the authors say, which they believe could advance its treatment. The research includes both functional imaging studies and treatment with invasive or noninvasive brain stimulation, both of which have bearing on a proposed disease model of increased activity in brain regions that form a cortico-striato-thalamo-cortical loop. (Source: American Journal of Psychiatry)

Company Partners with University to Develop Neurostimulator for Obstructive Sleep Apnea

Feb. 2, 2021 - Nyxoah announced a collaboration and exclusive licensing agreement with Vanderbilt University to develop next-generation neurostimulation technologies to treat obstructive sleep apnea. (Source: Globe Newswire)

Company Begins Enrollment in Its Clinical Trial of Vagus Nerve Stimulation for Arthritis

Feb. 1, 2021 - SetPoint Medical announced it has enrolled the first patient in a clinical trial of vagus nerve stimulation for rheumatoid arthritis. (Source: Globe Newswire)

Authors Report a Proof-of-Concept Study of Neurostimulation in Arthritis Patients

Feb. 1, 2021 - Investigators report on a prospective, multicenter, open-label, single-arm, proof-of-concept study of auricular vagus nerve stimulation during active, treatment-resistant, rheumatoid arthritis. In the study, 27 patients were followed for 12 weeks. (Source: Lancet)

Patient Discusses Symptom Improvement after Spinal Cord Stimulation

Feb. 1, 2021 - A woman with complex regional pain syndrome raised £35,000 for spinal cord stimulation surgery. (Source: LADbible)

Report Highlights Research into Predicting Brain Response to Electrical Stimulation

Feb. 1, 2021 -  Researchers used novel electrical stimulation wave patterns to map brain activity, then employed new machine-learning techniques to analyze the data to predict the outcome of stimulation across multiple brain regions. They hope their work will have therapeutic applications. (Source: Medical Xpress)

Data Presented About Directional Deep Brain Stimulation in Parkinson's Disease

Jan. 29, 2021 - A study in 234 Parkinson's disease patients who were followed for up to 12 months following implantation of directional deep brain stimulation leads targeting the subthalamic nucleus was subject to a presentation during the January meeting of the North American Neuromodulation Society. (Source: NeuroNews)

Column Describes Neurotechnology Investigating Treatment of Neurological COVID-19 Impacts

December 2020 - An industry publication describes how investigations into treatment of respiratory or inflammatory disorders with neurotechnology devices are turning toward neurological impacts of COVID-19. (Source: Neurotech Reports)

New Terminology Proposed for a Persistent Pain Condition

Jan. 27, 2021 - An accepted manuscript, available online, by an international committee offers rationale for Failed Back Surgery Syndrome being renamed Persistent Pain Syndrome, rather than Chronic Pain after Spinal Surgery, as suggested by the new International Classification of Disease, ICD-11, which has been accepted by the World Health Organization. (Source: Pain Medicine)

Noninvasive Vagus Nerve Stimulation Method to Undergo Clinical Trial for Certain Post-COVID Symptoms

Jan. 26, 2021 - Soterix Medical Inc. announced a new clinical trial of home-based auricular vagus nerve stimulation for post-COVID neuropsychiatric symptoms, like fatigue, headache, or anxiety. (Source: PR Newswire)

Obstructive Sleep Apnea Device Receives MRI Labeling

Jan. 26, 2021 - The company Nyxoah announced its neurostimulation implant to treat obstructive sleep apnea, Genio, has received CE mark magnetic resonance imaging conditional labeling, for full-body 1.5T and 3T MRI scans. (Source: Street Insider)

Review Discusses Current Spinal Cord Stimulation Options to Treat Chronic Pain

Jan. 24, 2021 - A review covers neurostimulation for intractable chronic neuropathic pain. (Source: Brain Sciences)

Noninvasive Stimulation Trialed for Analgesia Post-Surgery

February 2021 - Researchers report a pilot randomized controlled trial of auricular neurostimulation during recovery from colorectal surgery, including a subgroup analysis by age. (Source: Diseases of the Colon & Rectum)

Brain Stimulation Device Receives FDA Clearance for Migraineurs Aged 12 and Above

Jan. 25, 2021 - Theranica's remote neurostimulation device has received expanded FDA approval for children aged 12 and up, the company announced, to treat episodic and chronic migraine. (Source: Healio)

Cardiac Care Team Reports on Smartphone - Implant Magnetic Interaction

Jan. 25, 2021 - In a single-person study, Heart Rhythm published correspondence in which authors report being able to suspend activity of an implantable cardioverter defibrillator by holding an iPhone 12 over the implant. The article says the phone has a circular array of magnets around a central charging coil to accommodate the company's "MagSafe" accessories. The iPhone manufacturer Apple addressed the concern with support document guidance to keep the devices at least six inches apart. (Source: The Verge)

Study Investigates Noninvasive Brain Stimulation to Reduce Tremor in Essential Tremor Patients

Jan. 25, 2021 - In a study, researchers used transcranial alternating current stimulation to suppress tremor in patients with essential tremor. (Source: Medical Xpress)

Woman with Parkinson's Disease Recounts Her Experience as a Deep Brain Stimulation Patient

Jan. 24, 2021 - In a column, a Parkinson's disease patient in Vancouver, British Columbia gives a vivid description of her surgery for a deep brain stimulation system, and benefits she noticed. (Source: Globe and Mail)

Company Announces FDA Approval for Deep Brain Stimulation System

Jan. 22, 2021 - Boston Scientific announced FDA approval for its fourth-generation Vercise Genus deep brain stimulation system. (Source: Mass Device)

News Segment Features Man with Dystonia, Treated by Neuromodulation

Jan. 22, 2021 - A television segment follows up on a Pennsylvania man with dystonia who received a deep brain stimulation system 21 years ago - at the time, being the youngest person to do so, a couple of years before DBS received a humanitarian device exemption from the FDA for that condition. (Source: WPXI)

Missouri Man Describes Improvement in Parkinson's Disease Symptoms After Deep Brain Stimulation

Jan. 20, 2021 - An article features a man who was diagnosed with Parkinson's disease while pursuing agriculture during retirement, and received a deep brain stimulation system to help manage his symptoms. (Source: KTVO)

Study Evaluates Obsessive Compulsive Behavior Following Personalized Noninvasive Brain Stimulation

Jan. 19, 2021 - An article in Nature Medicine describes research into the effect of  transcranial alternating current stimulation on obsessive compulsive behavior. The stimulation targeted the orbitofrontal cortex, and was personalized to the intrinsic frequency of the reward network. (Source: HealthDay)

Study Explores "Personalized" Brain Stimulation for Depression

Jan. 18, 2021 - Nature Medicine reports on a proof-of-concept study of intracranial brain stimulation in a patient with depression. (Source: UCSF)

Researchers in Texas are Enrolling Patients with Cervical Spinal Cord Injuries in a Clinical Trial of Vagus Nerve Stimulation

January 2021 - A clinical trial of vagus nerve stimulation will investigate its effect in people with cervical spine injuries on movement and a sense of touch. (Source: UT Dallas)

Clinical Trial Will Examine Post-Surgical Neurostimulation for Pain Control

Jan. 15, 2021 - A randomized sham-controlled clinical trial will evaluate the effect of percutaneous peripheral nerve stimulation on postoperative opioid consumption following orthopedic surgery. (Source: Clinical Pain Advisor)

Overview Discusses Deep Brain Stimulation for Chronic Pain

Jan. 15, 2021 - An article recounts research into deep brain stimulation for chronic pain. (Source: Neurology Advisor)

Company Announces U.S. Launch of Spinal Cord Stimulator

Jan. 14, 2021 - Boston Scientific announced it has launched its WaveWriter Alpha spinal cord stimulator systems in the United States. (Source: Mass Device)

Clinical Trial Begins of Adaptive Deep Brain Stimulation in Parkinson's Disease

Jan. 14, 2021 - Medtronic announced the first enrollment in a clinical trial of adaptive deep brain stimulation (DBS) in Parkinson's disease, Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD). (Source: Seeking Alpha)

Study Investigates Noninvasive Stimulation in Essential Tremor

Jan. 13, 2021 - Researchers report on the effect on essential tremor of transcranial cerebellar stimulation that is phase-locked to the tremor movement. (Source: Imperial College London)

Laboratory Research Demonstrates Injectable Brain Electrode

Jan. 13, 2021 - An international team reports wirelessly stimulating the brains of freely moving mice using injectable magnetoelectric nanoelectrodes activated by an external magnetic field. (Source: Science Advances)

Company Announces Breakthrough Device Designation from the FDA for Noninvasive Device for Alzheimer's Disease

Jan. 12, 2021 - Cognito Therapeutics announced its noninvasive neurostimulation device has received FDA Breakthrough Device designation for the treatment of cognitive and functional symptoms associated with Alzheimer’s disease. (Source: Argus Press)

Clinical Trial Starts of Noninvasive Neurostimulation for Upper-Extermity Rehabilitation after Spine Injury

Jan. 12, 2021 - ONWARD, formerly known as GTX Medical, announced patient enrollment has started in a trial of noninvasive spinal cord stimulation therapy in spine-injured patients who are undergoing rehabilitation for hand and arm function. (Source: Argus Press)

Company Announces Breakthrough Device Designation from the FDA for Noninvasive Device for Alzheimer's Disease

Jan. 12, 2021 - Cognito Therapeutics announced its noninvasive neurostimulation device has received FDA Breakthrough Device designation for the treatment of cognitive and functional symptoms associated with Alzheimer’s disease. (Source: Argus Press)

Clinical Trial Starts of Noninvasive Neurostimulation for Upper-Extermity Rehabilitation after Spine Injury

Jan. 12, 2021 - ONWARD, formerly known as GTX Medical, announced patient enrollment has started in a trial of noninvasive spinal cord stimulation therapy in spine-injured patients who are undergoing rehabilitation for hand and arm function. (Source: Argus Press)

Researchers Study Augmenting Upper-Limb Rehabilitation with Neurostimulation

Jan. 12, 2021 - Researchers combined noninvasive stimulation with physical rehabilitation of the hands and arms in spine-injured patients. (Source: UW Medicine)

Neuromodulation Centre Will Offer Noninvasive Brain Stimulation for Depression

Jan. 11, 2021 - Southern Health NHS Foundation Trust became the first in its region to offer depression treatment using repetitive transcranial magnetic stimulation, and one of the few health service trusts in England to launch a Neuromodulation Centre offering the treatment. An article says the service was "introduced earlier than planned due to the COVID-19 pandemic" to be available to people who struggle with mental health issues during the lockdown. (Source: Southern Daily Echo)

Neurostimulation Device Receives FDA Clearance

Jan. 11, 2021 - Spark Biomedical's wearable neurostimulator for treating opioid withdrawal received FDA clearance. (Source: FDA News)

Company Raises $38.5 Million for Device Trial in Amputation Pain

Jan. 7, 2021 - Neuros Medical, Inc. announced it raised $38.5 million in series BB financing to complete enrollment in a pivotal trial of its nerve-block technology in post-amputation pain. (Source: Neuros Medical)

Deep Brain Stimulation for Mild Alzheimer's Disease Receives Breakthrough Device Designation

Jan. 6, 2021 - Functional Neuromodulation Ltd. announced Breakthrough Device designation from the FDA for stimulation of the fornix using the Boston Scientific Corp. Vercise™ deep brain stimulation systems in patients aged 65 or older who have mild probable Alzheimer's disease that is not adequately controlled with medications. (Source: PR Newswire)

Company Announces Results of Trial of Noninvasive Brain Stimulation for Acute Migraine

Jan. 6, 2021 - Neurolief announced pivotal clinical trial findings from its study of an external brain stimulation system for self-treatment of migraine. The device stimulates occipital and trigeminal nerves. (Source: Business Wire)

Virtual Realty and Spinal Cord Stimulation Combined in Study of Patients with Chronic Leg Pain

Jan. 5, 2021 - A study explored combining spinal cord stimulation treatment for chronic leg pain with a virtual reality simulation that illuminates the patient's virtual leg when it receives treatment. (Source: WV News)

Implantation Starts in Obstructive Sleep Apnea Trial

Jan. 5, 2021 - Nyxoah S.A. announced the first patient was implanted in its pivotal study of a hypoglossal nerve stimulation device for obstructive sleep apnea. (Source: Street Insider)

Device Receives FDA Clearance for Withdrawal Symptoms

Jan. 4, 2021 - Spark Biomedical, Inc. announced FDA clearance of its transcutaneous auricular neurostimulation therapy for relief of opioid withdrawal symptoms. (Source: Globe Newswire)