2020 News Briefs - International Neuromodulation Society

Earlier News:

Review and Meta-Analysis Compares Spinal Cord Stimulation Waveforms for Treating Chronic Low Back Pain

Sept. 23, 2020 - A systemic review and meta-analysis gathered evidence for various spinal cord stimulation waveforms -- tonic, burst, and high-frequency -- relative to each other for treating chronic refractory low back pain. The analysis included randomized controlled trials and prospective cohort studies; the authors there were some heterogeneity and limitations in evidence, and that evidence of longitudinal efficacy is needed for the more-novel waveforms. (Source: Pain Physician)

Pilot Study Will Use Accelerated Approach to Transcranial Magnetic Stimulation

Sept. 22, 2020 - Nexstim Plc announced a pilot study for a new treatment protocol for severe depression is starting in Finland. In it, intermittent theta burst magnetic stimulation is given several times a day for one week, rather than a conventional approach in which transcranial magnetic stimulation is given once a day for several weeks. (Source: Globe Newswire)

Review Includes Peripheral Nerve Stimulation for Acute Post-Operative Pain

September 2020 - A review about two types of regional analgesia for acute post-operative pain that are "free of many of the limitations of both opioids and local anesthetic-based techniques" includes percutaneous peripheral nerve stimulation, saying it is "unique . . . in that it does not induce sensory, motor, or proprioception deficits and is cleared for up to 60 days of use." The review, however, calls for additional validation in the setting of acute pain through randomized controlled trials of the two non-pharmaceutical methods it covers. (Source: Anesthesiology)

Laboratory Study Provides Insight into Neuronal Effects of Ultrasound Neuromodulation

Sept. 18, 2020 - A laboratory study in a transgenic mouse brain slice model to determine effective parameters to elicit neuromodulation through ultrasound showed its application increased calcium signaling, the neuronal response rate depended on pulse repetition frequency, and it reversed effects of a sodium channel blocker. (Source: Scientific Reports)

Novel, Intermittent Stimulation to be Studied in Participants Cleared for Deep Brain Stimulation for Movement Disorder

Sept. 24, 2020 - A newly posted open-label clinical trial, Novel Paradigms of Deep Brain Stimulation for Movement Disorders, will evaluated symptoms and cognitive function as 20 subjects undergo periods of novel stimulation patterns, varying in frequency, contact location, and/or temporal pattern. Investigators at Cleveland Clinic initiated the trial after preclinical observations about intermittent, coordinated reset, stimulation. (Source: Clinicaltrials.gov)

Mixed-Methods Analysis Evaluates Patient Experiences with Spinal Cord Stimulation for Failed Back Surgery Syndrome

Sept. 23, 2020 - A study of patients in the Netherlands who received spinal cord stimulation for failed back surgery syndrome explored their expectations and experiences and found quality-of-life and psychosocial themes related to outcomes, including stigma regarding chronic pain and spiritual well-being, with acceptance and coping emerging as motifs among the various themes. (Source: Neuromodulation: Technology at the Neural Interface)

$31 Million Funding Round for Company Developing Implantable Neurostimulator for Migraine

Sept. 22, 2020 - Salvia BioElectronics B.V. announced it has raised $31 million in a Series A round of funding. The company is developing an implantable neurostimulation approach to chronic migraine based on subcutaneous bioelectronic foils. (Source: PR Newswire)

Wearable-Pain-Relief Device Manufacturer Adds Smartphone-Based Stimulation-Control App

Sept. 22, 2020 - NeuroMetrix, Inc. has launched the Quell smartwatch app to control its over-the-counter wearable, transcutaneous electrical nerve stimulation device for knee, foot and leg pain. (Source: Street Insider)

Visual Prosthetic Clinical Trial Resumes in Los Angeles

Sept. 22, 2020 - Second Sight Medical Products Inc. announced that in-person visits have resumed for four participants who are enrolled in its Early Feasibility Study of the Orion® Visual Cortical Prosthesis System at the UCLA Medical Center. Visits were paused in March due to the COVID-19 pandemic. (Source: Street Insider)

Review Considers Patient Experience with Neuromodulation

Sept. 23, 2020 - A systemic review in Neuromodulation of seven published studies of qualitative patient experience with neuromodulation therapy tracked four broad themes: coping with chronic pain, expectations, managing challenges and regaining normalcy. (Source: Pain Medicine News)

Authors Study Stimulation-Induced Dyskinesia in Meige Syndrome

Sept. 21, 2020 - Eight physicians in Beijing published a retrospective assessment of 32 patients who underwent deep brain stimulation for Meige syndrome, comparing programming control factors in 10 who had stimulation-induced dyskinesia and 22 others who didn't. They found the patients with dyskinesia had active contacts on the therapeutic stimulation lead that were in a different area of the subthalamic nucleus than the patients who didn't have dyskinesia. (Source: Neuromodulation: Technology at the Neural Interface)

Paper Examines Access to Deep Brain Stimulation for Parkinson's Disease in High-Income Countries

Sept. 1, 2020 - Two authors sought to determine treatment gaps in deep brain stimulation for Parkinson's disease in nine high-income countries. (Source: Value in Health Regional Issues)

Device Approval in Canada Announced

Sept. 21, 2020 - Axonics Modulation Technologies, Inc. announced Health Canada approval of its next-generation rechargeable implantable neurostimulator for the Axonics r-SNM® System, which provides sacral neuromodulation therapy. (Source: Business Wire)

Noninvasive Neurostimulator is Subject to a Patent

Sept. 21, 2020 - NeuroMetrix, Inc. announced issuance of a U.S. patent for its wearable transcutaneous electrical nerve stimulation technology that adjusts stimulation levels based on the user's body position, regulating control in response to the device orientation. (Source: Street Insider)

Team Describes Prototype That May Enable Personalized Prosthetics

Sept. 21, 2020 - A research team described rapid prototyping of soft implants for use as neuromuscular interfaces, which they say might enable personalized bioelectronics for neuroprosthetic applications. Demonstrated in small laboratory animals and in zebrafish, they say the prototypes are "leveraging the robotically controlled ink-jet deposition of low-viscosity conductive inks, extrusion of insulating silicone pastes and in situ activation of electrode surfaces via cold-air plasma". (Source: Nature Biomedical Engineering)

Facility in the UAE Serves Patients with Deep Brain Stimulation Systems

Sept. 21, 2020 - Last year, the Cleveland Clinic Abu Dhabi began evaluating patients for deep brain stimulation, with around six to seven patients who may receive the surgery there next month. In the meantime, the facility has been performing programming updates for nearby patients who were not able to travel to their implanting centers to have those visits due to the pandemic. (Source: The National)

Newspaper Profile Features Arkansas's First Female Neurosurgeon to Become a Full Professor

Sept. 20, 2020 - The University of Arkansas for Medical Science announced that Dr. Erika Petersen --who joined the faculty 10 years ago and directs the neurosurgery program with a burgeoning deep brain stimulation service -- has become the first female neurosurgeon to be promoted to full professor in Arkansas. (Source: Arkansas Gazette)

Company Devises Subcutaneous Route for Pain Control with Ketamine

Sept. 19, 2020 - An article describes how an agent sometimes delivered intrathecally, ketamine, was formulated to be delivered subcutaneously through a customized insulin delivery device for short-term, acute pain control. (Source: Forbes)

Effectiveness of Various Neurostimulation Techniques for Tinnitus Evaluated in Meta-Analysis

Sept. 18, 2020 - A meta-analysis of of 32 studies involving 1,458 participants evaluated effectiveness of different noninvasive brain stimulation therapies for tinnitus. (MD Linx)

Clinical Trial Will Evaluate Brain Implant That Delivers Near-Infrared Light

Sept. 17, 2020 - A clinical trial starting soon in France will follow 14 early-stage Parkinson's disease patients, half of whom will have an implanted fiber optic cable that delivers pulses of near-infrared light to their brain's substantia nigra. The trial will evaluate safety and clinical benefits on symptoms and disease progression, in addition to looking for evidence of neuroprotection of dopamine-producing cells. (Source: Science)

Noninvasive Acoustic Neuromodulation Studied in Patients with Insomnia

Sept. 17, 2020 - In a clinical trial, 107 people with insomnia received 10 hour-long sessions of placebo or noninvasive acoustic neuromodulation intended to influence the autonomic nervous system. The placebo used random tones and the active interevention used so-called "high-resolution, relational, resonance-based electroencephalic mirroring (HIRREM)," which monitors brainwaves and plays back audible tones of varying pitch. (Source: Newswise)

Clinicians Report on Supervised Three-Week Test of Sacral Neuromodulation for Overactive Bladder

Sept. 16, 2020 - A prospective study followed patients with overactive bladder for one year who received a sacral neuromodulation system after a three-week test phase that included two waves of reprogramming, each a week apart, in non-responders. (Source: Urology Times)

Company Presents Data About Tremor Changes Associated with Use of Its Noninvasive Electrical Stimulation Device

Sept. 14, 2020 - Cala Health presented data about hand-tremor symptoms from 44 people with essential tremor who used the company's noninvasive electrical stimulation system over the course of three months. (Source: Fierce Biotech)

Patient in Israel Receives Vagus Nerve Stimulator Implant for Treatment-Resistant Depression

Sept. 14, 2020 - A person with severe depression that did not respond to medical treatment has received a vagus nerve stimulator implant for the condition in Israel, where he was reportedly the first person in that country to receive the device, which has been available as a treatment for epilepsy there for 15 years. (Source: Jerusalem Post)

University Acquires Brain-Machine Interface Technology

Sept. 11, 2020 - Tufts University has been donated the brain-computer-interface enterprise BrainGate  and its technology, along with fund from BrainGate's former executive chairman, alumnus Jeff Stibel, to establish a research consortium and two endowed professorships at the university to further develop and potentially commercialize aspects of the technology. (Source: Medical Design and Outsourcing)

CE Mark Announced for Deep Brain Stimulation System

Sept. 10, 2020 - Boston Scientific announced its fourth-generation Vercise Genus deep brain stimulation system received CE mark approval in Europe. (Source: Mass Device)

Open-Source Platform Allows Near-Real Time Closed-Loop Stimulation During Intracranial EEG Recording

December 2020 - Researchers published their tool to investigate closed-loop stimulation for research and therapeutic use, an open-source platform for near real-time closed-loop stimulation designed for intracranial EEG recordings and stimulation that they call a Closed-Loop System for Electrical Stimulation (CLoSES). (Source: NeuroImage)

Noninvasive Neurostimulator for Acute Migraine Gets CE Mark Approval in Europe

Sept. 8, 2020 - Theranica announced CE mark approval for its wearable neurostimulation device for acute treatment of migraine, Nerivio. (Source: Mass Device)

In England, NICE Issues Sacral Neuromodulator Guidance for Overactive Bladder

Sept. 8, 2020 - England's National Institute for Health and Care Excellence (NICE) has issued guidance recommending use of the rechargeable implantable sacral neuromodulation system by Axonics Modulation Technologies for the treatment of overactive bladder, the company announced. (Source: OA Online)

Clinical Trial Results Presented for Phrenic Nerve Stimulator in Patients on Mechanical Ventilation

Sept. 8, 2020 - Lungpacer Medical, Inc. announced presentation of results of RESCUE 2, a multicenter randomized controlled trial of its phrenic nerve stimulator in patients on mechanical ventilation. The system uses a transvenous neurostimulator to activate the diaphragm as a temporary measure to strengthen the muscle and prepare patients to breathe independently upon weaning from mechanical ventilation. A pivotal clinical trial, RESCUE 3, is underway in the U.S. and Europe. The RESCUE 2 results were presented at the European Respiratory Society 2020 Virtual International Congress. (Source: StreetInsider.com)

Spinal-Cord-Injury Patients Surveyed About Neuromodulation for Bladder and Bowel Function

Sept. 7, 2020 - A survey of 370 individuals with spinal cord injury investigated their needs for managing neurogenic bladder and bowel function, and willingness to adopt neuromodulation interventions. (Source: Spinal Cord)

U.S. FDA Publishes Letter About Spinal Cord Stimulation Trial Phase

Sept. 4, 2020 - The U.S. FDA published a letter to healthcare providers reminding physicians to follow product labeling and carry out a trial stimulation period prior to permanently implanting a spinal cord stimulation device. (Source: FDA)

Clinical Trial Concerns Implanted Neuroprosthetic System for Hand Control in Individuals with Mid-Cervical Spinal Cord Injury

Sept. 2, 2020 - A Phase 2 trial has been initiated of a a third-generation neuroprosthetic device, the Networked Neuroprosthetic (NNP) System, at Case Western Reserve University. The fully implantable system is designed to improve hand function in individuals with mid-cervical level spinal cord injuries. (Source: CDMRP)

Researchers Report Nanoscale Clip Development for Preclinical Work in Peripheral Nerve Stimulation

Aug. 21, 2020 - Researchers share progress in creating nanoscale 3D-printed clips that have thin-film electrodes to interface with small-fiber peripheral nerves in small animal models for recording nerve activity over weeks-long time frames. The devices provide multi-channel, current-steering-based stimulation. A goal is to enable longitudinal studies to support development of therapeutics involving closed-loop control of peripheral circuit function. (Source: Nature Communications)

Grant Will Aid Research Into Neuromodulation to Address Brain-Circuit Rhythms in Mental Disorders

Sept. 3, 2020 - The U.S. National Institute of Mental Health awarded researchers $6.6 million for work on treating mental health disorders with neurostimulation that addresses the synchrony of rhythms in brain circuits. (Source: EurekAlert)

Company Announces Webinar to Release Full Pivotal Study Results Concerning Its Sacral Neuromoduation Device

Sept. 2, 2020 - Axonics Modulation Technologies, Inc. plans a webinar Sept. 9 where investigators will present full 2-year clinical results of the pivotal study of its sacral neuromodulation device. Previously, the company released topline results of the ARTISAN-SNM study. (Source: OA Online)

Article Presents Survey of Patients Awaiting Spinal Cord Stimulation During Pandemic

Aug. 21, 2020 - In seven U.K. centers, patients on a waiting list for spinal cord stimulation (SCS) for chronic pain were prospectively surveyed in May about their views on the impact of the pandemic, lockdown, and willingness to attend a National Health Service hospital to receive an SCS implant. (Source: British Journal of Pain)

Device Company Raises $67 Million

Aug. 31, 2020 - NeuroPace has raised $67 million to support commercial expansion of its implantable brain-stimulation technology for refractory focal epilepsy. (Source: MD+DI)

Brain-Implant Startup Demonstrates Technology Development

Aug. 28, 2020 - The brain-chip startup Neuralink held a live video event demonstrating neuron-spike data from a pig implanted with its technology, saying they received an FDA Breakthrough Device designation in July, and hope to recruit more staff. (Source: The Verge)

Paper Addresses Deep Brain Stimulation for Post-Infarct Dystonia

Aug. 26, 2020 - Co-authors report on a series of three patients who have post-infarct dystonia and received deep brain stimulation to the subthalamic nucleus due to striatal infarcts that decreased confidence in the globus pallidus internus as a possible stimulation target. (Source: Stereotactic and Functional Neurosurgery)

Maker of Brain-Interface Device Announces an FDA Breakthrough Device Designation

Aug. 28, 2020 - Synchron, Inc. announced receiving an FDA breakthrough device designation for its brain implant, Strentrode. The investigational device is designed to translate electrical activity in the brain and provide stimulation. It is delivered to its target location with a technique similar to placement of a neurovascular stent, through blood vessels. The company is investigating its potential to aid individuals with paralysis. (Source: BioWorld)

Article Says Neurostimulator Company Targeting Sleep Apnea Plans to Raise Funds on the Brussels Stock Exchange

Aug. 27, 2020 - An article says the company Nyxoah plans to list on Euronext Brussels in order to raise $70.9 million to fund development and sales of its neurostimulator implant for obstructive sleep apnea. (Source: New York Times)

Collaborators Work on Adaptive Deep Brain Stimulation for Parkinson's Disease

Aug. 27, 2020 - An article describes an academic collaboration to develop a wirelessly charged adaptive deep brain stimulation system, which is intended to detect and respond to biomarkers of Parkinson's disease symptoms, rather than provide continuous stimulation. (Source: Taipei Times)

Study Looks at Disparities in Spinal Cord Stimulation in the U.S.

Aug. 26, 2020 - A publication discusses socioeconomic disparities in utilization of spinal cord stimulation in the U.S., with privately insured patients having higher odds of having it for complex regional pain syndrome or failed back surgery syndrome, vs. patients with Medicare, and Medicaid patients having even lower odds of having it; black and Hispanic patients had higher odds of having it than white patients. (Source: MDLinx)

Grant Will Help Fund Study of Noninvasive Brain Stimulation in Alzheimer's Disease

Aug. 26, 2020 - A $1.5 million grant from the U.S.-based Alzheimer's Association and Bill Gates was announced for a team from the U.K. Dementia Research Institute and the Imperial College, London. The grant will help fund study of noninvasive temporal interference brain stimulation to boost functions of the hippocampus, to test if it is possible in the most-affected areas of the brain to revive mitochondrial function, which plays a role in early stages of brain degeneration seen in the disease. (Source: Yahoo! News)

Study Analyzes Deep Brain Stimulation for Cluster Headache

Aug. 22, 2020 - Looking at four cohorts, investigators statistically analyzed imaging data, outcomes, and related measures in 40 patients who underwent deep brain stimulation for refractory chronic cluster headache, and identified two influential stimulation areas. (Source: Annals of Neurology)

Brain-Interface Company Anticipates an Upcoming Technology Demonstration

Aug. 25, 2020 - The brain-implant chip startup Neuralink has announced it plans a progress update on Aug. 28, which reportedly involves a real-time demonstration of neurons firing. (Source: Daily Mail)

Company Seeks Premarket Approval for a Tibial Nerve Stimulator

Aug. 24, 2020 - Valencia Technologies Corporation announced it filed for premarket approval from the FDA of its leadless tibial nerve stimulator to treat overactive bladder. (Source: PR Newswire)

Article Presents Early Clinical Steps in Development of a Potential Visual Prosthesis

Aug. 17, 2020 - An article about technology development in Israel that combines bioelectronic and artificial intelligence capabilities mentions work toward an artificial retina implant, among among technologies addressing the diagnosis or treatment of neural disease. (Source: CTech)

Company Announces Noninvasive Brain Stimulation for Smoking Cessation

Aug. 24, 2020 - BrainsWay Ltd. announced FDA clearance from the FDA for use of its deep transcranial magnetic stimulation system as an aid in short-term smoking cessation in adults. The company intends a controlled market release in 2021. (Globe Newswire)

Peripheral Nerve Stimulator Implantation for the Upper Extremity

Aug. 11, 2020 - Co-authors published a technical note about peripheral nerve stimulation in the upper extremity for median, ulnar, and radial nerves. (Source: Pain Medicine)

Paper Presents a Case of Paired Associative Stimulation During Walking Rehabilitation after Spinal Injury

Aug. 17, 2020 - Scientists published research into using paired associative stimulation that combines transcranial magnetic stimulation and peripheral nerve stimulation during walking rehabilitation undertaken by a patient who has an incomplete spinal cord injury. (Source: Science Daily)

Dorsal Root Ganglion Treatment Effectiveness Graded in Systematic Review

Aug. 17, 2020 - An international work group graded treatment effectiveness in a systematic review of prospective trials and observational studies of dorsal root ganglion stimulation for the treatment of chronic focal neuropathic pain and complex regional pain syndrome. (Source: Pain Medicine)

Meta-Analysis Looks at Effectiveness and Adverse Effects of a Neurostimulation Target for Essential Tremor

Aug. 1, 2020 - A team of authors in China analyzed outcomes, including effectiveness over time, and adverse effects that were published up to 2019, involving 1,714 patients with essential tremor who received deep brain stimulation that targeted the ventral intermediate nucleus. (Source: Neural Plasticity)

Researchers Plan Feasibility Study of Responsive Brain Stimulation in Treatment Refractory Obesity

July 27, 2020 - Researchers published the design of a feasibility study of bilateral responsive neurostimulation of the nucleus accumbens for loss-of-control eating by individuals who have treatment-refractory obesity. (Source: Neurosurgery)

Review: MRI Compatibility of Neuromodulation Devices

Aug. 18, 2020 - A review presents guidelines for MRI compatibility of available neuromodulation devices, including spinal cord stimulators, intrathecal drug delivery systems, peripheral nerve stimulators, deep brain stimulators, vagal nerve stimulators, and sacral nerve stimulators. (Source: Neuromodulation: Technology at the Neural Interface)

Design Published of Randomized Controlled Clinical Trial of Neurostimulation in Back Pain

Aug. 16, 2020 - Clinicians published the design of a multicenter, randomized controlled trial begun in 2018 that compares 10 kHz spinal cord stimulation plus conventional medical management to conventional medical management alone, in patients with refractory back pain who have not had major back surgery, and are not good candidates for surgery. (Source: Pain Practice)

Authors Report on Respiratory Function in a Paralyzed Individual Treated with Noninvasive Spinal Cord Stimulation

Aug. 17, 2020 - Authors report  on breathing and coughing ability in a patient with tetraplegia who was treated with transcutaneous electrical spinal cord stimulation. (Source: Themagazineplus.com)

Article Addresses Occipital Nerve Stimulation

Aug. 11, 2020 - Co-authors present their approach to using ultrasound-guided placement of occipital nerve stimulators in three patients with occipital neuralgia, who were followed for an average of eight months. (Source: Pain Medicine)

Study: Deep Brain Stimulation Therapy and Function in Early Motor Complications of Parkinson's Disease

Aug. 17, 2020 - Researchers published a study of the impact of deep brain stimulation on social and occupational functioning in people who have early motor complications from Parkinson's Disease. (Source: Parkinson's News Today)

Study Looks at Deep Brain Stimulation Cycle Effects on Gait in Parkinson's Disease

Aug. 17, 2020 - In a preprint, authors present their study of entraining stepping movements of Parkinson's disease patients thought alternating a stimulation cycle speed close to stepping speed in patients with deep brain stimulators targeting the subthalamic nucleus. (Source: bioRxiv)

Authors Investigate Dorsal Root Ganglion Stimulation Motor Effects Following Paralysis

Aug. 14, 2020 - In a case series published in Early View in Neuromodulation, researchers report on using bilateral dorsal root ganglion stimulation to evoke motor response in the upper leg of patients who have chronic motor complete spinal cord injury. (Source: NeuroNews)

Abstract Presents Early Results of Controlled Trial of Neurostimulation in Painful Diabetic Neuropathy

September 2020 - In a meeting abstract about a prospective, multicenter, randomized, controlled trial, early results are presented that compare 10 kHz spinal cord stimulation with conventional medical management vs. conventional medical management alone in treating painful diabetic neuropathy. (Source: EASD Virtual Meeting)

Study Explores Potential of Epidural Stimulation to Regain Hand and Arm Movement after Stroke

Aug. 13, 2020 - A clinical trial in Pittsburgh will investigate evoked motor responses in the course of 30 days of epidural spinal cord stimulation in people who have lost arm and hand function following subcortical stroke. (Source: Trialbulletin.com)

Brain Imaging Studies Help Suggest Optimal Brain Stimulation Target for Obsessive Compulsive Disorder

July 14, 2020 - Investigators write in Nature Communications that certain fiber tracts seem most effective as a stimulation target when treating obsessive compulsive disorder with deep brain stimulation. The study was based on pre- and post-implant MRI imaging in 50 patients who were treated at a number of centers around the world. (Source: Psych Central)

Company Announces FDA Clearance for Obsessive Compulsive Disorder Treatment

Aug. 12, 2020 - The company MagVenture announced it received FDA clearance for its transcranial magnetic stimulation therapy for adjunctive treatment of obsessive compulsive disorder. (Source: Mass Device)

Survey Examines the Need to Standardize Implanted Stimulator Connectors

Aug. 11, 2020 - A team of authors has published results of a survey of members of the North American Neuromodulation Society regarding potential development of standard connectors for implanted stimulators, a possibility being explored by the Institute of Neuromodulation. (Source: Neuromodulation: Technology at the Neural Interface)

Tibial Nerve Stimulation System Clinical Trial Starts

Aug. 11, 2020 - A clinical trial of an implantable tibial nerve stimulation system has begun in the U.S. and Europe in patients with overactive bladder. The OverActive Bladder Stimulation System Study (OASIS) is an open-label prospective trial to evaluate efficacy in treating urinary urge incontinence. (Source: Urology Times)

Case Series: 10 kHz Spinal Cord Stimulation for Chronic Thoracic Pain

July/August 2020 - A team of authors has published a multicenter retrospective chart review of 19 patients who had 10 kHz spinal cord stimulation for chronic thoracic pain, with outcomes gathered at 1, 6, and 12 months post-implant. They also analyzed anatomic lead placement. (Source: Pain Physician Journal)

Company Enters Licensing Agreement for Neural Processing and Decoding Software

Aug. 11, 2020 - Blackrock Microsystems LLC, a microelectrode array maker for brain-computer interfaces, obtained a license to commercialize neural processing and decoding software, NeuroKey, from the Wyss Center for Bio and Neuroengineering. (Source: Business Wire)

FDA Breakthrough Device Designation Announced for Noninvasive Neuromodulation Headset

Aug. 10, 2020 - Neurolief announced an FDA breakthrough device designation for its multichannel noninvasive brain neuromodulation device for the treatment of major depressive disorder. (Source: Mass Device)

Reviewers Analyze Studies of Noninvasive Vagus Nerve Stimulation for Headache Relief

Aug. 8, 2020 - A literature review in Neuromodulation analyzed findings from six clinical trials of noninvasive vagus nerve stimulation for acute headache relief. (Source: AJMC)

Aneasethetists in the UK Release Guidance on Spinal Cord Stimulation Competencies for Pain Medicine Specialists

July 2020 - The Faculty of Pain Medicine of the Royal College of Aneasethetists has issued "Guidance on Competencies for Spinal Cord Stimulation", which outlines core, and advanced, knowledge for pain medicine specialists who either may encounter the therapy in the course of their work, or who are providers of the therapy. (Source: Faculty of Pain Medicine)

Company Seeks FDA Clearance for Noninvasive Neurostimulator

Aug. 6, 2020 - Helius Medical Technologies, Inc. submitted a request for FDA clearance of its noninvasive neurostimulation device for treatment of gait deficit in multiple sclerosis as an adjunct to a supervised therapeutic exercise program. (Source: Globe Newswire)

Vagus Nerve Stimulation Studied in Language-Learning Task

Aug. 6, 2020 - Researchers at the University of California, San Francisco, and the University of Pittsburgh published a study into using transcutaneous vagus nerve stimulation to enhance a language-learning task, in which native English speakers were asked to distinguish between four Mandarin tones. (Source: UCSF)

Retrospective Analysis Compares Re-Operation Rates of Paddle or Percutaneous Spinal Cord Stimulators

Aug. 4, 2020 - A single-center retrospective chart review analyzed re-operation rates of percutaneous and paddle leads in spinal cord stimulation systems. (Source: Pain Medicine)

Science & PINS Prize for Neuromodulation Announced

Aug. 6, 2020 - Viviana Gradinaru, professor of neuroscience and biological engineering at the California Institute of Technology, is the 2020 grand prize winner of the Science & PINS Prize for Neuromodulation for her essay about development of minimally invasive gene delivery tools and identification of novel therapeutic targets, both in and outside the brain, in strategies that include minimally invasive optogenetic-mediated modulation. (Source: AAAS)

Prospective Trial Assesses Brain-Responsive Neurostimulation in Adults with Medically Intractable Seizures

July 20, 2020 - In a long-term prospective open label trial, brain-responsive neurostimulation was assessed for safety, efficacy, and quality of life in adults who were treated over nine years for medically intractable focal onset seizures. (Source: Neurology)

Sacral Neuromodulation Study Evaluates Bowel Function

July18, 2020 - A retrospective study evaluated the clinical effect of sacral neuromodulation on bowel dysfunction in patients with neurogenic bladder. (Source: Colorectal Disease)

Company Announces Enrollment in Trial of Noninvasive Stimulation for Opioid Withdrawal in Newborns

Aug. 5, 2020 - Spark Biomedical announced three newborns have completed a clinical trial of opioid withdrawal treatment using its pediatric transcutaneous auricular neurostimulator. (Source: ForexTV)

FDA Approval for Rechargeable Sacral Neuromodulator Announced

Aug. 4, 2020 - Medtronic announced FDA approval for its rechargeable InterStim Micro sacral nerve stimulator and SureScan leads to treat overactive bladder, fecal incontinence and non-obstructive urinary retention. (Source: MedTech Dive)

Studies Present Seizure-Reduction Data from Neurostimulation for Epilepsy

Aug. 3, 2020 - An article summarizes data from two studies concerning seizure reduction in patients with epilepsy treated with a responsive neurostimulation system. (Source: Neurology Live)

Results Published from Transcranial Magnetic Stimulation Data Collaboration

Aug. 3, 2020 - Theta-burst transcranial magnetic stimulation data were pooled from 22 studies in a collaboration focused on evaluating individual variability of response. Based on the findings, the collaborators offer some recommendations for controlling methodological variability. (Source: Brain Stimulation)

Review: Circuit Dysfunction and Neurostimulation Trials in PTSD

July 31, 2020 - A review discusses ongoing neurostimulation trials, and highlights the current understanding of neuronal circuit dysfunction in post-traumatic stress disorder. (Source: Journal of Neurosurgery)

Article Presents Transcranial Magnetic Stimulation for Depression

Aug. 1, 2020 - An editorial introduces a journal article about a study using an accelerated, high-dose, resting-state functional connectivity–guided intermittent theta-burst transcranial magnetic stimulation for treatment-resistant depression. (Source: The American Journal of Psychiatry)

Study Explores Noninvasive Brain Stimulation Method During Post-Stroke Motor Activity

July 29, 2020 - Researchers report on lower extremity function in 12 subjects who had chronic stroke and participated in a double‐blind, placebo controlled, crossover study of the safety, feasibility, and potential effectiveness of bilateral high-frequency repetitive transcranial magnetic stimulation during cycling. (Source: Neuromodulation: Technology at the Neural Interface)

Lateral Spinal Cord Stimulation Studied to Restore Sensation in Limb Amputees

July 29, 2020 - Researchers report on using lateral spinal cord stimulation in four upper-limb amputees to study the feasibility of evoking sensations to restore somatosensation. (Source: eLife)

Safety and Efficacy of Vagus Nerve Stimulator Studied in Rheumatoid Arthritis

July 28, 2020 - A safety-and-efficacy study assessed a miniaturized vagus nerve stimulator in patients with drug-resistant rheumatoid arthritis. (Source: The Lancet Rheumatology)

Retrospective Case Series Reports Outcomes of Patients Receiving Occipital Nerve Stimulation

July 28, 2020 - Clinicians in France retrospectively reviewed 60 patients with intractable occipital headaches who received occipital nerve stimulation following referral between 2008 and 2014. (Source: Neuromodulation: Technology at the Neural Interface)

Researchers Study Paresthesia-Free Nerve Root Stimulation in Chronic Pain Patients

July 28, 2020 - Researchers in Canada investigated paresthesia‐free high‐frequency spinal nerve root stimulation in 14 patients with intractable, dermatomal neuropathic pain. (Source: Neuromodulation: Technology at the Neural Interface)

Two-Year Results Announced in Pivotal Trial of Sacral Nerve Stimulator

July 28, 2020 - Axonics Modulation Technologies released topline results of its two-year pivotal clinical study of its sacral neuromodulation device in 129 for treatment of urinary and bowel dysfunction. (Source: MD+DI)

Case Series Reports on Potential New Neurostimulation Target in Spinal Cord Injury

July 24, 2020 - Researchers report investigating dorsal root ganglion stimulation to evoke motor response in patients with motor-complete spinal cord injury, as a potential new target for spinal cord stimulation treatment. (Source: Neuromodulation: Technology at the Neural Interface)

Paper: Neurostimulation in Chronic Postsurgical Pain

July 24, 2020 - A study evaluated 10-kHz spinal cord stimulation in chronic postsurgical pain. (Source: MD Linx)

Company Plans Trial of Noninvasive Brain Stimulation in Depression

July 24, 2020 - Soterix Medical Inc. announced investigational device exemption clearance from the FDA to begin a trial of transcranial direct current stimulation for patients with major depressive disorder. (Source: New Kerala)

Company Pursues Auricular Vagus Nerve Stimulation in COVID-19-Related Pneuomonia

July 20, 2020 - Nemechek Technologies, LLC is seeking an FDA Emergency Use Authorization for its  transcutaneous auricular vagus nerve stimulation device in patients with pneumonia from coronavirus infection. The device is being evaluated in COVID-19 patients in a clinical trial in Argentina. (Source: WFMJ)

Research Grant Announced for Abdominal Electrical Stimulation

July 23, 2020 - In COVID-19-related research into therapeutic electrical stimulation, researchers in Australia have received a $2.4 million grant for research into electrical stimulation of the abdominal muscles in people with upper-body paralysis, to evaluate if it could reduce their time on mechanical ventilation. The funding from the government of New South Wales is part of a $15 million research package for spinal cord injury research. (Source: Sydney Morning Herald)

Company Announces Approval of Neurostimulator Patient-Programmer Application

July 23, 2020 - Abbott announced FDA approval of an iOS-compatible application allowing patients to control their spinal cord stimulator or deep brain stimulation systems on a handheld mobile device. (Source: MD Mag)

Irish Noninvasive Neurostimulation Company Raises Funds

July 22, 2020 - Belfast-based Neurovalens has raised £5.1 million for clinical trials of its noninvasive neurostimulation technology, which the company is developing to potentially treat diabetes, insomnia, anxiety and obesity. (Source: Mobi Health News)

Pilot Trial Compares Deep Brain Stimulation in Parkinson's Disease to Optimum Medical Management without Neurostimulation

July 21, 2020 - A prospective, randomized controlled pilot trial compared, over five years, deep brain stimulation in early stage Parkinson's disease with optimum medical management alone. (Source: Neurology Advisor)

Patient in Germany Receives Lung-Pacing Implant as Part of Clinical Study to Wean COVID-19 Patients from Mechanical Ventilation

July 10, 2020 - A medical center announced implanting the first patient in Germany in a safety-and-effectiveness study, RESCUE-3, of an implanted diaphragm pacing system to help wean COVID-19 patients from mechanical ventilation. (Source: Innovations Report)

Review Discusses Brain Connectivity and Neuromodulation Effects

July 20, 2020 - A review addresses the "growing intersection between two fields: neuromodulation and brain connectomics." (Source: NeuroImage)

Researchers Study Neural Response to Mechanical Stimulation

July 20, 2020 - In work they said may have implications for future therapy development, researchers report in ACS Nano basic research into using magnetic nanodiscs as a tool for studying neural responses to stimulation of cells' pressure receptors. The study included focusing on pressure-sensitive neurons in the dorsal root ganglion. (Source: Mirage)

Pilot Study Investigates Vagus Nerve Stimulation in Rheumatoid Arthritis

July 16, 2020 - A pilot, sham-controlled study of vagus nerve stimulation in patients with drug-refractory rheumatoid arthritis was presented at the 2020 Interdisciplinary Autoimmune Summit. (Source: Healio)

Early Stage Neuromodulation Company Targeting Chronic Pain Raises $30 Million

July 15, 2020 - Presidio Medical, which is developing a neuromodulation technology platform to treat chronic pain, has raised $30 million in a funding round led by Invus Opportunities. (Source: Medical Device Network)

Study Evaluated Spinal Cord Stimulator Sensations Post-Implant

July 10, 2020 - A retrospective study of post-spinal-cord-stimulator unpleasant paresthesia and/or dysesthesia was presented at the 2020 annual meeting of the American Academy of Pain Medicine. (Source: Pain Medicine News)

Noninvasive Neurostimulator Receives Emergency Use Authorization for Breathing Issues

July 14, 2020 - Devicemaker electoCore announced the U.S. FDA has issued an emergency use authorization for its vagus nerve stimulation device to be used in asthmatic people with difficulty breathing who are potentially affected by the novel coronavirus. (Source: Fierce Biotech)

Paper Analyzes Factors Concerning Spinal Cord Stimulator Removal

July 11, 2020 - A journal article presents analyses conducted to describe timing, and identify factors, associated with spinal cord stimulation removal. (Source: NeuroNews)

Study Tracks Cognitive State of Parkinson's Disease Patients Receiving Long-Term Deep Brain Stimulation

July 9, 2020 - A 10-year follow-up study reported in Neurology evaluated whether long-term deep brain stimulation in people with Parkinson's disease is cognitively safe and explored whether there is a changed risk for development of dementia. (Source: Parkinson's News Today)

Device Company Announces Conditional Labeling for 3T MRI Scans

July 2, 2020 - Axonics Modulation Technologies announced an FDA premarket approval supplement for conditional labeling to permit full-body 3T MRI scanning in patients implanted with its sacral neuromodulation system. (Source: Mass Device)

Cardiology Journal Hails Heart Failure Device Study Design as a Potential Future Model

July 2, 2020 - Noting that, among other things, device studies are challenging because they are usually smaller than drug trials, difficult to blind, randomize and control, and have diverse endpoints, an editorial in the Journal of the American College of Cardiology about the BeAT-HF (Baroflex Activation Therapy in Patients with Heart Failure and a Reduced Ejection Fraction) trial calls the trial's unique design a "model" for future clinical trials of therapies intended to treat a life-threatening or irreversibly debilitating disease. The editorial notes that initial therapy approval might be based on intermediate endpoints with the expectation that clinical reductions in morbidity be pursued in ongoing studies.(Source: Medtech Dive)

Report: Post-Stimulation, and Without Locomotor Training, Some Spine-Injured Patients Develop Spontaneous Volitional Movement

 June 30, 2020 - Researchers report on the development of spontaneous volitional movement in the absence of stimulation in some individuals who received long-term spinal cord stimulation, after complete spinal cord injury, without locomotor training being part of the study protocol. (Source: Frontiers in Systems Neuroscience)

Researchers Report Results of Pilot Five-Year Clinical Trial in Parkinson's Disease Patients

June 30, 2020 - A pilot study over five years compared outcomes in 30 early Parkinson's disease patients who received deep brain stimulation plus medical management vs. patients who only received optimal medical management alone. (Source: U.S. News & World Report)

Authors Propose a Multidimensional Responder Index for Chronic Pain Therapies

June 27, 2020 - A team of authors propose a multidimensional responder index that they say may provide a more meaningful response measure than a numeric rating scale in clinical trials for chronic pain therapies. (Source: Neuromodulation: Technology at the Neural Interface)

Company Begins Marketing Neurostimulator in Australia

 June 18, 2020 - The Nevro Omnia spinal cord stimulation system became available July 1 in Australia. (Source: BioSpectrum)

Company Announces Device to Address Opioid Withdrawal Symptoms

June 29, 2020 - Masimo announced a percutaneous neurostimulator, worn behind the ear, designed to reduce opioid withdrawal symptoms. (Source: Mobi Health News)

FDA Approval Announced for Deep Brain Stimulation System

June 25, 2020 - Medtronic announced FDA approval of a deep brain stimulation system it said had "the ability to chronically capture and record brain signals while delivering therapy to patients with neurologic disorders associated with Parkinson’s disease, essential tremor, dystonia, epilepsy or obsessive-compulsive disorder." (Source: FirstWord Medtech)

Spinal Cord Stimulation Study Reports Psychological Measures at 12 Months

June 25, 2020 - In 12-month results from an ongoing multicenter clinical trial of burst spinal cord stimulation for chronic pain, researcher report pain-related psychological measures, in addition to changes in opioid use. (Source: Neuromodulation: Technology at the Neural Interface)

Study of Deep Brain Stimulation Evaluates Brain Tractography and Impulsiveness in Parkinson's Disease Patients

June 24, 2020 - Researchers in Australia have published, with overseas colleagues, work to map how structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson’s disease patients. A neurologist on the team was interviewed by ABC radio about the work, which the authors believe could help to plan electrode placement and inform stimulation titration to limit such side effects post-implant. (Source: Cosmos)

FDA Approval Announced for Neurostimulator for Chronic Low Back Pain

June 22, 2020 - Mainstay Medical Inc. announced FDA approval of its implantable neurostimulation system to treat intractable chronic low back pain associated with multifidus muscle dysfunction in adults who have failed therapy, including pain medications and physical therapy, and are not candidates for spine surgery. (Source: BioSpace)

Study Looks at Comparative Outcomes of Spinal Cord Stimulation in Patients with a Family History of Mental Illness

June 12, 2020 - An article summarizes a poster from the North American Neuromodulation Society annual meeting concerning prospectively gathered patient outcomes at 6 and 12 months after spinal cord stimulator implantation, in which outcomes were compared between a cohort who had a family history of psychiatric illness and another group of patients who did not. (Source: Pain Medicine News)

Basic Research Explores Directional Effects of Vagus Nerve Stimulation

June 17, 2020 - A news feature discusses a recent basic scientific investigation in rats of the effect of vagus nerve stimulation on heart rate and breathing rate, with the concept that an anodal block of the therapy might direct it in a more targeted fashion than current methods. (Source: Technology Networks)

Poster Presents Three-Month Study Results of Spinal Cord Stimulation in Painful Diabetic Neuropathy

June 15, 2020 - Three-month results were presented in a poster at the virtual scientific sessions of the American Diabetes Association in a study comparing 10 kHz spinal cord stimulation with conventional medical management alone in patients with painful diabetic neuropathy. (Source: Medscape)

Company Announces Reimbursement for Device

June 8, 2020 – Mainstay Medical Holdings plc announced that its implantable restorative neurostimulation system to treat disabling chronic low back pain has been approved for inclusion in the list of reimbursed prosthesis in Australia, effective July 1, 2020. (Source: Business Wire)

Report Presents Spine-Injured Patients' Use of Prosthetic Arm with Sense of Touch

June 9, 2020 - A research report about four men with transhumeral amputations describes their use of a self-contained robotic arm that includes hand sensation, which allows them to do such tasks as ski, repair cars, and canoe. (Source: JAMA)

Neurostimulation System Receives Breakthrough Device Designation

June 9, 2020 - GTX medical announced FDA Breakthrough Device Designation for its implantable targeted epidural spinal stimulation system designed to aid recovery of leg motor functions and neurological control after spinal cord injury. (Source: Business Wire)

First Implants Announced in Pivotal Trial of Neurostimulator in Patients with Overactive Bladder

June 10, 2020 - Neurspera Medical Inc. announced the first chronic clinical implants of its wireless sacral nerve stimulator in a pivotal trial in patients with urinary urge incontinence. (Source: PR Newswire)

Article Summarizes Current Status of Neurotechnology Applicable to Alzheimer's Disease

June 8, 2020 - An article summarizes neurotechnologies and research that are applicable to Alzheimer's disease and dementia. (Source: Neurotech Network)

Analysis Presents Explanation Factors in Spinal Cord Stimulation

June 3, 2020 - A study analyzed factors associated with spinal cord stimulator explantation in a cohort of 252 patients. (Source: Neuromodulation: Technology at the Neural Interface)

Device Maker Announces Distribution Agreement

June 1, 2020 - Endonovo Therapeutics, Inc. announced it has entered into an agreement to distribute its noninvasive stimulation device for reduction of post-operative pain and edema in Taiwan. (Source: Globe Newswire)

Device for Restless Leg Syndrome Receives FDA Approval

June 4, 2020 - Privately held Noctrix Health, Inc. announced it received FDA Breakthrough Device Designation for its wearable peripheral nerve stimulator to treat medically refractory primary moderate-to-severe restless leg syndrome. (Source: Medical Dialogues)

Study Explores Noninvasive Neurostimulation Effects on Tics in Tourette Syndrome

June 4, 2020 - Researchers report in Current Biology results of a study into the effects of noninvasive median nerve stimulation on tics in people with Tourette syndrome. (Source: Health Day)

Technology for Checking Neurostimulator Prior to Imaging Scan Receives FDA Premarket Approval

June 3, 2020 - Axonics Modulation Technologies, Inc. announced FDA approval of its wireless patient patient remote control with SmartMRI technology. (Source: Business Wire)

Regulatory Classification Posted for Surgical-Planning Software Recall

June 1, 2020 - A notice on the FDA website identifies as Class 1 Medtronic's Aug. 9, 2019 recall of an auto-registration feature of its  Cranial software version 3.0 or newer (3.0, 3.1, 3.1.1) with StealthStation DBS License or StealthStation S8 Software with Stealth DBS License. The software was distributed from Feb. 1, 2026 to May 1, 2019, and 54 consignees were notified. (Source: Medscape)

Registry Outcomes of Intrathecal Ziconotide for Chronic Pain Reported

May 29, 2020 - A publication presents an analysis of results of a registry, which was an open-label, long-term, mulitcenter observational study, that evaluated the short- and long-term safety and effectiveness of intrathecal ziconotide based on patient-reported outcomes. (Source: Pain Medicine)

Authors Raise the Potential of Neuromodulation of Inflammatory Response in COVID-19-Related Organ Dysfunction

May 26, 2020 - A multidisciplinary group of authors from Duke University has published a journal article on "Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19." The authors describe the potential for multiorgan failure from inflammatory cytokines and the potential for reversing inflammation through vagus nerve stimulation. They add that a human study into influencing the inflammatory reflex through splenic nerve stimulation has begun (sponsored by Galvani Bioelectronics). (Source: Journal of Cardiovascular Translational Research)

Analysis of Efficacy of Deep Brain Stimulation in Refractory Obsessive Compulsive Disorder

May 28, 2020 - A systemic review and meta-analysis evaluates deep brain stimulation in refractory obsessive compulsive disorder, drawing on reported data from eight randomized controlled trials and 38 observational studies that together comprise more than 300 patients. (Source: MDLinx)

Preprint: Noninvasive Neuromodulation Methods, the Inflammatory Response, and COVID-19

May 22, 2020 - A team of researchers in Brazil has published a perspective on the use of noninvasive neuromodulation to manage disorders related to COVID-19, such as those involving the inflammatory reflex. (Source: SSRN preprint server)

An Individual Experience with a Noninvasive Neurostimulation Device for Migraine

May 28, 2020 - A health advocate for people with chronic illness who has constant head pain relates her experience after having been offered to try a noninvasive neuromodulation device, available by prescription, for the treatment of migraine. (Source: Pain News Network)

Presentation Covers a Randomized, Controlled Trial of Percutaneous Tibial Nerve Stimulation in Overactive Bladder

May 2020 - A presentation on percutaneous tibial nerve stimulation for overactive bladder at the American Urological Association's virtual meeting covered a double-blind, randomized vs sham efficacy trial of 220 patients and three years follow-up. (Source: Uro Today)

Pain Catastrophizing Results Presented from Neurostimulation Studies in Chronic Pain Patients

May 22, 2020 - An article covers results regarding pain catastrophizing scores in two studies of burst neurostimulation for pain that were presented at the 2020 Annual North American Neuromodulation Society meeting in Las Vegas. One presentation showed 12-month results from a multicenter prospective study. The other, a feasibility study with six-month results, investigated variations in low doses of electrical stimulation. (Source: Pain Medicine News)

Review Discusses Neural Interfaces for Upper Extremity Rehabilitation Robotics

May 15, 2020 - An invited review discusses what might be required to transition devices to restore upper limb control to a clinical market. The authors say characteristics of peripheral nerve interfaces and brain-machine interfaces could enable them to be concurrently developed. (Source: Muscle & Nerve)

Registry Study Compares Depression Scores Between Groups of Bipolar Patients, With or Without Neurostimulation

May 20, 2020 - LivaNova announced publication of a study based on a 5-year prospective registry that compared treatment as usual, with or without additional vagus nerve stimulation, in patients with treatment-resistant bipolar disorder. (Source: Mass Device)

Journal Publishes 12-Month Results for Sacral Neuromodulation System

May 19, 2020 - Axonics Modulation Technologies, Inc. announced 1-year results were published from the safety and efficacy study of its rechargeable sacral neuromodulation system in patients with urinary urge incontinence. Axonics also plans to launch a multicenter registry study in the U.S. to collect data on all approved indications.(Source: Olean Times Herald)

Noninvasive Brain Stimulation and Cognitive Performance

May 16, 2020 - An article provides an overview of research into noninvasive brain stimulation and optimizing cognitive function. (Source: Neuroscience News)

Video Features a Man with Essential Tremor Who Received Deep Brain Stimulation

May 13, 2020 - An essential tremor patient is featured in a segment about deep brain stimulation therapy. (Source: KVIE)

Wrist-Worn Device Studied for Essential Tremor

May 8, 2020 - A large prospective study investigated a wrist-worn transcutaneous neurostimulator in patients with essential tremor. (Source: Medscape)

Transcutaneous Spinal Cord Stimulation Studied in Upper Limb Rehabilitation

May 1, 2020 - As a potential approach to upper limb rehabilitation, researchers sought to elicit arm and hand movements using transcutaneous cervical spinal cord stimulation. (Source: Journal of Neural Engineering)

Authors Address the Issue of Managing Intrathecal Drug Delivery Devices During the Pandemic

May 15, 2020 - An article features advice from a letter to Neuromodulation about management of intrathecal drug delivery therapy during the COVID-19 pandemic. (Source: NeuroNews)

Brain Stimulation at Home, Guided by Telemedicine, Allowed for Clinical Study in Depression

May 15, 2020 - Neuroelectrics announced the U.S. FDA has allowed a supplemental clinical study protocol to conduct direct current stimulation therapy at home using telemedicine for patients with major depressive disorder. (Source: Neuroelectrics)

Device to Address Dry Eye Disease Receives FDA Clearance

May 14, 2020 - Olympic Ophthalmics announced FDA clearance for its noninvasive cutaneous nerve stimulation device to induce acute increased tear production in adults. The device is designed to stimulate the parasympathetic activity that controls tear-film homostasis. (Source: Mass Device)

Visual Prosthesis Uses Machine Learning to Stimulate Visual Cortex

May 14, 2020 - Research into stimulating the visual cortex with a temporal pattern is being explored to help blind people visualize specific shapes or characters, such as letters. (Source: Inverse)

Man in UK Profiled Regarding His Vagus Nerve Stimulation System for Depression

May 14, 2020 - A man who has battled depression for years granted an interview about the success he has found through an implanted vagus nerve stimulator (VNS) provided by one of the few NHS trusts with a VNS service. (Source: BBC)

Brain-Computer Interface Aids Study into Memory Consolidation During Sleep

May 11, 2020 - In a study, two people with paralysis who have brain-computer interfaces for the Braingate research project were studied to learn how memories are transferred to long-term storage during sleep. (Source: Science Times)

Company Announces CE Mark for Neurostimulator

May 14, 2020 - Nevro Corp. announced CE mark approval for its rechargeable Omnia spinal cord stimulator system, which provides frequencies of 2 - 10,000 Hz. (Source: P&T Community)

Article Features Publication Concerning Interest in Vagus Nerve Stimulation for COVID-19 Respiratory Issues

May 13, 2020 - NeuroNews featured the Neuromodulation article "The Use of Non‐invasive Vagus Nerve Stimulation to Treat Respiratory Symptoms Associated With COVID‐19: A Theoretical Hypothesis and Early Clinical Experience". (Source: NeuroNews)

Company Announces Breakthrough Status Designation for Its Noninvasive Neurostimulator

May 12, 2020 - Helius Medical Technologies said its device, the portable neuromodulation stimulator (PONS), received a breakthrough designation from the FDA to use in conjunction with physical therapy to address gait issues from mild or moderate multiple sclerosis. (Source: NeurologyLive)

Guidelines Proposed for Noninvasive Brain Stimulation Treatment During the COVID-19 Pandemic

May 12, 2020 - Opinions shared in an April online conference of NYC Neuromodulation 2020 were synthesized into proposed guidelines for noninvasive brain stimulation clinical services or research activities during the COVID-19 pandemic. The publication covers transcranial magnetic stimulation (TMS) and low-intensity transcranial electrical stimulation (tES), including transcmanial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS). (Source: Brain Stimulation)

Paper Features Subanalysis of Non-Surgical Patients with Refractory Back Pain

May 8, 2020 - A subanalysis presents prospectively collected clinical outcome data for 26 non‐surgical refractory back pain patients who were treated with 10 kHz spinal cord stimulation. (Source: Anaesthesia)

Device Company Announces $130 Million Offering

May 7, 2020 - Axonics Modulation Technologies Inc. announced a public offering of 4 million shares for $32.50 apiece, closing on May 12. The company said proceeds of the $130 million offering will fund commercialization of its rechargeable sacral neuromodulation system in the U.S., Europe, and Canada. (Source: Odessa American)

Investigational Device Exemption Announced for Device Studied in Autoimmune Disorder

May 6, 2020 - SetPoint Medical announced it has received approval from the FDA to study its vagus nerve stimulation system in patients with medication-resistant rheumatoid arthritis. The company anticipates a double-blind, randomized, sham-controlled clinical trial of this bioelectronic platform at 40 U.S. sites in patients who are incomplete responders or are intolerant to biologic or targeted synthetic disease modifying anti-rheumatic drugs. (Source: GlobeNewsire)

Brain Machine Interface Effort Explores Noninvasive Helmets

May 5, 2020 - The startup Kernal is developing helmets that noninvasively track electromagnetic movement and blood flow as a way to record brain activity. (Source: Bloomberg Businessweek)

Research Aims to Apply Neuromodulation to Reduce Dysphonia Symptoms

May 4, 2020 - A $50,000 grant will allow further development of a noninvasive neuromodulation technology for dysphonia. The technology involves small vibrators attached to the skin above the voicebox, in order to stimulate laryngeal mechanoreceptors. An ongoing clinical trial indicated effects on vocal symptoms caused by spasms in the musculature that is used in speech production. (Source: University of Minnesota)

Artificial Arm Includes Neural Interface

April 30, 2020 - A brief report describes use over three to seven years by four patients of a bone-anchored, self-contained robotic arm with sensory and motor components. (Source: New England Journal of Medicine)

New Curriculum Focuses on Spinal Cord Stimulation Training for Practitioners

May 1, 2020 - A multidisciplinary committee of the North American Neuromodulation Society has developed a training curriculum for spinal cord stimulation, as described in an article in Neuromodulation: Technology at the Neural Interface. (Source: NeuroNews)

Neurotechnology Development in the Context of COVID-19

April 2020 - An article about neurotechnology developments notes ways that neuromodulation therapies are being applied to, or studied for, treatment of respiratory issues in patients with COVID-19. An accompanying column mentions the potential for developing therapies or protection for neurological effects, and a growth in telemedicine that could include neurotechnology monitoring applications. (Source: Neurotech News)

FDA Grants Emergency Use Authorization for Lung Pacing System

April 27, 2020 - Lungpacer Medical announced its phrenic nerve stimulation system has received FDA Emergency Use Authorization to wean off patients who have COVID-19 from ventilators. The stimulator electrode is introduced via a catheter into a vein near the phrenic nerve, and provides diaphragm pacing to avert or reverse ventilator-induced diaphragm atrophy or dysfunction. (Source: Medgadget)

Young Adults Approved for Obstructive Sleep Apnea Implant

April 29, 2020 - The FDA has extended the approval of the implanted hypoglossal nerve stimulator by Inspire Medical Systems for obstructive sleep apnea to cover patients aged 18 to 21, as well as the previous age group aged 22 and older. (Source: Neurology Advisor)

Review: Transcranial Magnetic Stimulation for Pain, Headache, and Comorbid Depression

April 27, 2020 - A panel provided recommendations and treatment guidelines for transcranial magnetic stimulation in managing neuropathic pain and headaches. (Source: Neuromodulation: Technology at the Neural Interface)

Spinal Cord Stimulation for Mobility Investigated in Patients with Advanced Parkinson's Disease

April 23, 2020 - Results were published of a prospective investigation of the effects on mobility of spinal cord stimulation in patients with advanced Parkinson's disease. (Source: Parkinson's News Today)

Spinal Cord Stimulation Effect on Blood Pressure Generates Research Interest

April 13, 2020 - A retrospective study suggests spinal cord stimulation for chronic pain produces transient reductions in blood pressure that may provide a rationale for studies investigating the burden of high blood pressure medication in this group. (Source: Clinical Autonomic Research)

Visual Prosthesis Company Provides Update

April 28, 2020 - Second Sight Medical Products, Inc. provided a business update, including the status of the six recipients of its Orion visual cortical prosthesis system. The company said it is assessing strategic options. (Source: Digital Journal)

Sacral Neuromodulation Study Data Published

April 28, 2020 - One-year outcomes were reported in a safety and efficacy trial of a rechargeable sacral neuromodulation system in patients with urinary urge incontinence. (Source: Physician's Weekly)

Scientists Study Brain Stimulation in an Animal Model of Parkinson's Disease Using Optogenetics

April 27, 2020 - In an animal model of Parkinson's disease, biomedical engineers have used a relatively fast-acting form of optogenetics, Chronos, to gain insight into motor dysfunction and potentially contribute to optimizing deep brain stimulation in patients. (Source: Science Daily)

Study Investigates Gastric Application of Vagus Nerve Stimulation

April 27, 2020 - Data were published regarding a potential gastric application of transcutaneous auricular vagus nerve stimulation. The data concern use of respiratory-gated auricular vagal afferent nerve stimulation (RAVANS), which delivers electrical pulses in tune with the respiratory rhythm, in study volunteers who had had frequent indigestion. (Source: Medical Xpress)

Article Provides Basis for Investigation of Noninvasive Vagus Nerve Stimulation in COVID-19

April 27, 2020 - An article, "Use of non‐invasive vagus nerve stimulation to treat respiratory symptoms associated with COVID‐19: A theoretical hypothesis and early clinical experience," presents scientific foundations, preliminary observations, and a discussion of mechanisms. The article states that randomized controlled clinical trials are anticipated. (Source: Neuromodulation: Technology at the Neural Interface)

Randomized Trial Will Investigate Vagus Nerve Stimulation Respiratory Effects in COVID-19

April 27, 2020 - The company electroCore announced the start of a randomized, controlled, investigator-initiated clinical trial in Spain, SAVIOR, of its noninvasive vagus nerve stimulation system in patients with COVID-19, to investigate its effects on respiratory symptoms. The announcement said a U.S.-based trial, SAVIOR-2, has begun institutional review board review. (Source: Globes)

Authors Publish Review of Peripheral Nerve Stimulation for Chronic Pain

April 24, 2020 - A review covers factors that influence the clinical success of peripheral nerve stimulation for chronic pain conditions. (Source: Bioelectronic Medicine)

Review Presents Noninvasive Stimulation of the Central or Peripheral Nervous System

May 2020 - An updated review of theoretical, physiological and practical aspects of noninvasive stimulation of brain, spinal cord, nerve roots and peripheral nerves follows up on an initial 1994 review that was prepared under the auspices of the International Federation of Clinical Neurophysiology. (Source: Clinical Neurophysiology)

Research Team Reports Adding Sensory Feedback to Neural Interface

April 23, 2020 - Researchers report that, based on processing of sub-perceptual touch signals, they were able to provide some tactile feedback to a spinal-cord-injured person who has regained some hand function through use of a neural interface. (Source: Cell)

Researchers Work on Data-Sharing Effort for Neural Interface Recordings

April 16, 2020 - A spinout from Waterloo University in Canada announced work toward a future data repository of open-source information from wireless implantable neural interface technology for electrophysiology research. (Source: EurekAlert)

External Pain-Relief Stimulation System Subject to Clinical Trial

April 16, 2020 - Wearable external transcutaneous electrical nerve stimulation will be subject to a randomized study of physical therapy in patients who have fibromyalgia pain. (Source: BioSpace)

Emergency Use Authorization Issued for Diaphragm Pacing System for Use in COVID-19 Patients in the U.S.

April 15, 2020 - The TransAeris diaphragm pacing stimulator by Ohio-based Synapse Biomedical received an FDA emergency use authorization to permit its use in weaning patients with COVID-19 off mechanical ventilation. The system has CE mark in Europe. (Source: Regulatory Affairs Professionals Society)

Neurostimulator Approval Announced for Sacral Neuromodulation System

April 14, 2020 - Axonics Modulation Technologies, Inc. announced FDA approval of its rechargeable neurostimulator for sacral neuromodulation, which came through a premarket approval supplement. (Source: Business Wire)

Researchers Report Analysis Concerning Spinal Cord Stimulation Trial Phase and Infection Rate

April 8, 2020 - An analysis of data from the U.S. and Europe evaluated the length of a spinal cord stimulation trial period and infection rate. (Source: Neuromodulation: Technology at the Neural Interface)

Considerations for Chronic Pain Patients with COVID-19

April 8, 2020 - An article describes special needs and concerns about chronic pain patients with COVID-19. (Source: MedPage Today)

Research Suggests High-Density Brain Electrodes Can Survive More Than Six Years

April 8, 2020 - With preclinical results and laboratory testing to simulate device aging, scientist report they have developed brain implants with more than 1,000 electrodes that are protected with a biocompatible coating. (Source: Medical Xpress)

Grant Will Fund Research Into Light-Activated, Wireless Implantable Electrode

April 7, 2020 - The University of Pittsburgh announced a $437,144 grant from the National Science Foundation to further develop a light-activated wireless electrode for development of more precise neuronal stimulation. (Source: EurekAlert)

Paper Describes Investigation into "Remote" Neuromodulation for Acute Migraine

April 7, 2020 - Theranica Bioelectronics announced publication of a paper in which patients were given an option to incorporate remote electrical neuromodulation (REN) into treatment of acute migraine. The paper describes REN as "a novel acute migraine treatment, in which upper arm peripheral nerves (median and musculocutaneous) are stimulated to induce conditioned pain modulation—a descending endogenous analgesic mechanism in which sub-threshold conditioning stimulation inhibits pain in remote body regions". (Source: PR Newswire)

Noninvasive Brain Stimulation Study Proceeds in Patients with Chronic Pain

April 7, 2020 - Following a pilot placebo-controlled trial, researchers are planning an expanded study of transcranial alternative current stimulation in patients with chronic pain. (Source: WMC-5)

Researchers Attempt to Optimize Noninvasive Brain Stimulation for Depression

April 6, 2020 - An article describes how researchers have studied a particular protocol for repetitive transcranial magnetic stimulation in an attempt to optimize therapy for treatment-resistant depression. (Source: New Atlas)

Device Maker Seeks 3.0T MRI Conditional Labeling for Its Neurostimulator

April 6, 2020 - Axonics Modulation Technologies, Inc. announced it has submitted a premarket approval supplement to the FDA to seek full-body conditional labeling of its sacral neuromodulation system for 3.0T MRI scans. (Source: Odessa Arts)

International Neuromodulation Society Chapter Produces a Practice Guideline for Management of Neuromodulation Devices During the Pandemic

April 5, 2020 - In preparation for the suspension of all non-urgent elective surgery in the NHS for at least three months starting April 15, the Neuromodulation Society of the United Kingdom and Ireland, NSUKI, has produced a practice recommendation to aid in managing neuromodulation devices during that time. (Source: Neuromodulation Society of the United Kingdom and Ireland)

Investigators Publish an Anatomical Study Concerning Neuromodulation for Trigeminal Neuropathic Pain

April 3, 2020 - A medical research team has published their anatomical investigation of a potential intraoral route for neurostimular implantation to address trigeminal neuropathic pain in a way that may provide greater opportunity for secure anchoring, compared to the established approach to locate the foramen ovale for ablative procedures. (Source: Neuromodulation: Technology at the Neural Interface)

Neurostimulation Company Prices Public Offering, Convertible Senior Notes, Totaling Over $300 Million

April 2, 2020 - Nevro Corp. is raising more than $300 million through a public offering and convertible senior notes. (Source: Mass Device)

Noninvasive Neurostimulation Device Subject to an FDA Application for Emergency Use Authorization

April 2, 2020 - The company electroCore has submitted to the FDA an application for Emergency Use Authorization to facilitate study and clinical use of its gammaCore Sapphire noninvasive vagus nerve stimulation therapy for potential use to address respiratory symptoms associated with COVID-19. The application included non-clinical data and data from several pilot studies that involved patients with a variety of respiratory disorders. (Source: Street Insider)

Researchers Document Effects of Target Variations in Circuit-Based Neuromodulation for Depression

April 1, 2020 - In a retrospective analysis transcranial magnetic stimulation to the dorsolateral prefrontal cortex for patients with depression, an article describes how small variations in stimulation location were investigated in order to potentially address different depression symptoms, such as sleep disruption, worry, and negative mood. (Source: Science Translational Medicine)

Retrospective Review of Noninvasive Brain Stimulation After Onset of Vestibular Migraine

April 1, 2020 - A single-center retrospective review describes effects of external trigeminal stimulation after onset of vestibular migraine. (Source: Physicians Weekly)

Case Report: Neurostimulation in Tourette Syndrome

March 25, 2020 - A case report details treatment, using deep brain stimulation, of a 15-year-old with refractory Tourette syndrome and associated obsessive compulsive disorder. (Source: Stereotactic and Functional Neurosurgery)

Review Discusses Emerging Modalities and Implantable Technologies for Neuromodulation

March 31, 2020 - A review considers the future of neuromodulation devices that may help improve understanding of neural control of organ function and precisely modulate those functions in a programmable way. (Source: Cell)

Recording of Cortical Activity Translated Into Text

March 30, 2020 - Researchers reported on their efforts to train a machine-learning neural network to decode an electrocorticogram into a sentence. (Source: Nature Neuroscience)

Deep Brain Stimulation and Camptocormia Symptoms in Parkinson's Disease

March 29, 2020 - A medical team published results of a study that assessed improvements in Parkinson's disease-associated camptocormia following subthalamic deep brain stimulation. (Source: Medical Science Monitor)

Noninvasive Spinal Cord Stimulation Studied in Paralysis

March 25, 2020 - An international team researching transcutaneous electrical stimulation of the spinal cord (TESS) in individuals with tetraplegia published findings of its effect on observations of motor-evoked potentials in arm muscles elicited by cortical and subcortical stimulation. (Source: Journal of Neuroscience)

Paper Presents Novel Intermittent Burst Dosing for Spinal Cord Stimulation

March 26, 2020 - An article summarizes a paper published in Neuromodulation: Technology at the Neural Interface on novel intermittent burst dosing in spinal cord stimulation. (Source: NeuroNews International)

Researchers Study Working Memory and Noninvasive Brain Stimulation

March 24, 2020 - Research in healthy subjects tested the effect of transcranial magnetic stimulation on working memory, with and without cognitive load. (Source: EurekAlert)

INS Invites Mentor and Mentee Applications for Members' Neuromodulation Mentorship Program

March 24, 2020 - The International Neuromodulation Society invites applications from chapter leaders and members to participate in the INS Mentorship Program that is designed to engage the next generation of neuromodulation therapy practitioners through discussions about best practices in implantable technologies, clinical management and career development. Applications for both mentors and mentees are available, and will be reviewed by the INS board and members of the Young Neuromodulators and International Women in Neuromodulation committees. (Source: International Neuromodulation Society)

Sham-Controlled Trial Studies Noninvasive Electrical Stimulation in Movement-Evoked Pain

March 23, 2020 - A randomized sham-controlled trial studied if applying transcutaneous electrical nerve stimulation during two hours of daily activity at home for four weeks reduced movement-evoked pain and other patient-reported outcomes, compared to sham stimulation or none, in women with fibromyalgia. (Source: MDLinx)

Educational E-Health Tool Summarizes Recommendations on Referral to Spinal Cord Stimulation

March 19, 2020 - Recommendations from a European panel on appropriate referral to spinal cord stimulation is available as an educational e-health tool. (Source: Physician's Weekly)

Noninvasive Vagus Nerve Stimulation Studied for Improvement in Oromotor  Control for Feeding

March 18, 2020 - Transcutaneous auricular vagus nerve stimulation was studied in a prospective, open-label study in newborns who had oral feeding difficulties due to prematurity or neural injury, as an approach that was paired with bottle-feeding rehabilitation. (Source: Frontiers in Human Neuroscience)

Manufacturer Acquires Neuromodulation Technology Assets

March 17, 2020 - Cirtec Medical Corporation announced it has acquired intellectual property and some assets from Nuvectra Corporation to use as a platform to support their customers' development of various neuromodulation products for a variety of therapeutic applications. (Source: Benzinga)

Review Summarizes Studies of Noninvasive Brain Stimulation for Neuropathic Pain Following Spinal Cord Injury

March 13, 2020  - A review summarizes 11 studies, comprising three different types of noninvasive brain stimulation, in neuropathic pain following spinal cord injury, and identifies findings in one type concerning anxiety. (Source: American Journal of Physical Medicine & Rehabilitation)

Theory of Sensory Neuromodulation As a Potential Intervention for Neurological Disease

March 6, 2020 - A paper proposes that sensory neuromodulation may be employed to repair dysfunctional brain oscillations, and thus provide a broad therapeutic approach to neurological disease. (Source: Frontiers in Systems Neuroscience)

Authors Discuss Spinal Cord Stimulation in Parkinson's Disease

March 16, 2020 - A mini-review presents spinal cord stimulation in Parkinson's disease and potential relevant mechanisms. (Source: Bioelectronic Medicine)

Paper Describes a Deep Brain Stimulation Target in a Case of Epilepsy

March 10, 2020 - Physicians report on the use of deep brain stimulation of the anterior thalamic nucleus for treatment of refractory tuberous sclerosis-related epilepsy. (Source: World Neurosurgery)

Neurostimulator Designed to Address Swallowing Difficulties

March 10, 2020 - Phagenesis Ltd. announced its neurostimulator designed to improve swallowing in patients with dysphagia received Breakthrough Device Designation from the FDA and is CE marked in Europe. (Source: Medgadget)

Authors Summarize Findings Concerning Noninvasive Vagus Nerve Stimulation in Migraine or Cluster Headache

March 12, 2020 - A systematic review and meta-analysis summarizes six randomized controlled clinical trials of cervical noninvasive vagus nerve stimulation for migraine and cluster headache. (Source: Neuromodulation: Technology at the Neural Interface)

Researchers Compare Depressive Symptoms and Targets for Transcranial Magnetic Stimulation

March 12, 2020 - In a retrospective analysis using mapping from a large imaging database of functional connectivity, researchers compared how distinct clusters of depressive symptoms responded to different transcranial magnetic stimulation targets across independent retrospective data sets. (Source: American Journal of Psychiatry)

Company Announces Its Neurostimulator Has Received MRI Labeling

March 10, 2020 - NeuroPace, Inc. announced it has received MRI labeling from the U.S. FDA for the RNS-320 model of its responsive neurostimulation system that addresses certain types of medication-resistant epilepsy. (Source: Medgadget)

Chart Review Evaluates Noninvasive Vagus Nerve Stimulation in Vestibular Migraine

Feb. 26, 2020 - A retrospective chart review evaluated noninvasive vagus nerve stimulation for acute vestibular migraine. (Source: Pain Medicine News)

Peripheral Neurostimulator Implanted for Chronic Pain in the U.K.

March 12, 2020 - Bioness, Inc. announced the first implantation in the U.K. of its wireless neuromodulation device to treat chronic pain of peripheral nerve origin. (Source: PR Newswire)

Deep Brain Stimulation for Medically Refractory Epilepsy Performed in West Virginia

March 10, 2020 - A medical center announced the first deep brain stimulation procedures for medically refractory epilepsy were performed in West Virginia. (Source: WVU Medicine)

Noninvasive Stimulation Subject to Clinical Trial for Certain Types of Overactive Bladder

March 10, 2020 - A 12-week-long double-blinded sham-controlled clinical trial at the University of Southern California will evaluate transcutaneous electrical stimulation of the spinal cord in patients with overactive bladder due to neurological conditions, such as injury or stroke. (Source: EurekAlert)

Paper Reports Results from Deep Brain Stimulation in Patients with Refractory OCD

March 9, 2020 - Twelve-month results were reported in a series of 70 patients with refractory obsessive compulsive disorder (OCD) who received deep brain stimulation of the ventral anterior limb of the internal capsule. (Source: HCP Live)

Benelux-Area Implantation of Newer Hypoglossal Nerve Stimulator Announced

March 9, 2020 - Two Benelux patients with obstructive sleep apnea have been implanted with a newer, externally powered, hypoglossal nerve stimulation system. (Source: Globe Newswire)

Closed-Loop Deep Brain Stimulation Studied in Tourette Syndrome

March 2020 - Four individuals with Tourette syndrome who were implanted, as part of a larger clinical trial, with deep brain stimulation systems with sensing capabilities were studied for six months to differentiate tics from voluntary movement. The study authors believe that this physiological signal could potentially guide development of neuromodulation therapies for the disorder by using a closed-loop approach. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Data Presented on Patients with Chronic Knee Pain Who Received Peripheral Nerve Stimulation

March 5, 2020 - A case series presented at the American Academy of Pain Medicine Annual Meeting followed patients with chronic knee pain, who were implanted with a peripheral nerve stimulator to manage the pain, for two years. (Source: Medscape)

Lawmaker Proposes Telehealth Psychological Screening for Spinal Cord Stimulator Therapy

March 4, 2020 - A congressman in Ohio has introduced proposed legislation that would allow Medicare recipients to receive psychological screening for spinal cord stimulation through telehealth, which he said would help residents with chronic pain who have difficulty traveling from rural areas to appointments, and thereby potentially help increase access to neuromodulation. (Source: Sentinel Tribune)

CE Mark Approval Announced for Sinus Nerve Stimulator

March 3, 2020 - Tivic Health Systems, Inc. announced CE Mark approval for its handheld neurostimulator designed to provide temporary relief of sinus pain, pressure and congestion. (Source: Yahoo Finance)

Authors Contemplate Placebo-Controlled Spinal Cord Stimulation Studies

March 2020 - Given the evolving technology for spinal cord stimulation (SCS), a team of authors notes there are emerging opportunities to incorporate placebo controls and blinding when developing studies of SCS in chronic pain. (Source: Pain)

Authors Recommend Clarifying Descriptions of Certain Types of Neurostimulation

March 4, 2020 - A perspective article recommends distinctly identifying different types of burst neurostimulation. (Source: Expert Review of Medical Devices)

Study: Noninvasive Stimulation for Refractory Constipation

March 4, 2020 - An article summarizes a published, sham-controlled study of transabdominal interferential electrical stimulation in cases of refractory constipation. (Source: MedPage Today)

Physicians Summarize the Role of Neuromodulation for Chronic Pain

March 3, 2020 - A pair of physicians give an overview of neuromodulation as a therapy option for chronic pain in a health column. (Source: Harvard Health Blog)

Urology Meeting Presentation on Where to Place the Neuromodulation Lead

March 2020 - A point-counterpoint presentation about sacral, pudendal and tibial nerve stimulation, made at the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction Winter Meeting, is summarized in coverage of the meeting. (Source: Uro Today)

Research Into Deep Brain Stimulation for Obsessive Compulsive Disorder

March 1, 2020 - An editorial discusses research into deep brain stimulation (DBS) for obsessive compulsive disorder (OCD). The authors conclude, "The creation of a worldwide database for OCD, like the one developed for DBS in Tourette’s syndrome, would be an important step toward defining predictors of response. Finally, we need to leverage state-of-the-art neurotechnologies (like chronic sensing of local field potentials) to learn more about the neurocircuitry of OCD to discover biomarkers of response and to identify nodes (besides those already studied) that may be targeted to directly modulate the symptoms of OCD." (Source: American Journal of Psychiatry)

Neuromodulation Therapy Research Presented at Urology Meeting

March 2020 - An institutional review of long-term follow-up of sacral nerve stimulation (SNS) patients was presented at the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction Winter Meeting. In addition, data were presented on a leadless implantable tibial nerve stimulator and a rechargeable SNS system. (Source: Uro Today)

Depression Study Will Offer a Mobile App

Feb. 27, 2020 - LivNova said a substudy of its study that seeks to develop reimbursement evidence for implantable vagus nerve stimulation in depression will offer a wearable device and mobile app from Verily to gather additional information on study participants' behavior and response to treatment. (Source: MedTech Dive)

Review Summarizes Data About 10 kHz Spinal Cord Stimulation

Feb. 22, 2020 - A review summarizes current and emerging data about 10 kHz spinal cord stimulation for various pain syndromes. (Source: CNS Neuroscience & Therapeutics)

Spinout Raises About $16 Million for Its Heart Failure Neuromodulation Device

Feb. 24, 2020 - Minnesota-based Cardionomic Inc. has raised $15.8 million to further human testing and product development for its device that is designed to treat acute decompensated heart failure through catheter-based neuromodulation of certain nerve branches to increase heart contractibility and output. (Source: Twin Cities Business)

Column: Glial Cell Findings and the Potential Impact on Approaches to Spinal Cord Stimulation

January 2020 - A column recaps a keynote address and other developments from the North American Neuromodulation Society annual meeting in which the role of glial cells in pain processing and potential neuromodulation approaches was highlighted. (Source: Neurotech Reports)

Pain Patient in the UK Turns to Spinal Cord Stimulation to Manage Sciatica Pain

Feb. 24, 2020 - A woman who developed chronic sciatica after degenerative disc disease described being referred to spinal cord stimulation and her experiences with a newer device. (Source: Daily Mail)

Feasibility Study Results Published Regarding 10 kHz Neurostimulation in Chronic Abdominal Pain

February 2020 - Twelve-month results were published from a prospective, multicenter feasibility study of the safety and efficacy of 10 kHz spinal cord stimulation in chronic abdominal pain. (Source: Clinical and Translational Gastroenterology)

Feasibility Study Explores Deep Transcranial Magnetic Stimulation in Attention Deficit Hyperactivity Disorder

Feb. 20, 2020 - BrainsWay announced results of a randomized, blinded feasibility study of its deep transcranial magnetic stimulation system in adults with ADHD. (Source: Fierce Biotech)

Noninvasive Brain Stimulation Studied in Motor Recovery from Chronic Ischemic Stroke

Feb. 20, 2020 - Results were presented at the American Stroke Association's International Stroke Conference of a randomized, double-blind, sham-controlled clinical trial in 30 chronic ischemic stroke survivors to evaluate the safety and effectiveness of a wearable, multifocal, transcranial, rotating, permanent magnet stimulator for motor recovery. (Source: EurekAlert)

Patient in California Discusses Her Rechargeable Sacral Neurostimulator


Feb. 19, 2020 - An article presents a patient who received a rechargeable sacral neurostimulator for overactive bladder. (Source: WMC-5)

Neurologist Describes a Type of Parkinson's Disease that Recently Led to Postponement of a Concert Tour


Jan. 22, 2020 - In an article, a neurologist who specializes in movement disorder describes a type of Parkinson's disease associated with a gene involved in cellular energy metabolism, Parkin, and the option of deep brain stimulation therapy. Rock musician Ozzie Osbourne recently revealed he was diagnosed with the condition, and following an injury and hospitalization, postponed his North American leg of a concert tour. (Source: The Conversation)

Registry Tracked Patient Experience with Acute Noninvasive Vagus Nerve Stimulation for Cluster Headache

Feb. 18, 2020 - An article presents and discusses results from a prospective observational registry by gammaCore, concerning use of noninvasive vagus nerve stimulation in the acute treatment of episodic cluster headache from July 2017 to June 2018. (Source: American Journal of Managed Care)

Review: Noninvasive Brain Stimulation in Opioid Use Disorder

Feb. 14, 2020 - A systematic review of noninvasive brain stimulation for opioid use disorder considered findings from five studies, which totaled 150 study participants. (Source: Neuromodulation: Technology at the Neural Interface)

Trade Outlet Provides Overview of Neuromodulation Therapy for Chronic Pain

Feb. 14, 2020 - An article presents neuromodulation as a potential option for treatment of chronic pain, saying the therapy is an evidence-based innovation with advantages over oral painkillers, and can be trialed in advance. (Source: MedTech Outlook)

Review: Spinal Cord Stimulation as a Treatment for Ischemic Pain

Feb. 18, 2020 - A team of authors published a review about spinal cord stimulation in the treatment of inoperable ischemic pain. The review also references recommendations of the Neuromodulation Appropriateness Consensus Committee. (Source: Research Reports in Clinical Cardiology)

Researchers Study Vagus Nerve Stimulation in Motor Recovery

Feb. 17, 2020 - A study of closed-loop vagus nerve stimulation in rats examined the consequences of maladaptive central plasticity, subsequent to peripheral nerve injury, on motor function during rehabilitative training following nerve repair. (Source: University of Texas at Dallas)

Model Compares Projected Cost-Effectiveness of Systems for Spinal Cord Stimulation

Feb. 17, 2020 - A cost-effectiveness model compared a wireless spinal cord stimulation single-stage ("direct to implant") system versus a spinal cord stimulator that entails a screening stage prior to permanent implantation. (Source: Neuromodulation: Technology at the Neural Interface)

Study Explores Cortical Plasticity from Transcranial Direct Current Stimulation

May 2020 - A crossover, blinded, sham-controlled study of 22 healthy volunteers assessed stimulus-specific effects of transcranial direct current stimulation on cortical plasticity. (Source: NeuroImage)

Ultrasound Stimulation Studied in Memory Loss

Feb. 11, 2020 - A small pilot study of 35 people with probable Alzheimer's disease tracked the patients' neuropsychological scores over three months following ultrasound brain stimulation sessions with transcranial pulse stimulation, designed to activate relatively deep parts of the brain and potentially support "neuroplastic regeneration of diseased brain functions". (Source: JAMA Network)

Stimulation Device for Obstructive Sleep Apnea Undergoes Multi-Center Study

Feb. 13, 2020 - An open-label, single-arm study, at centers in Australia, France, and the United Kingdom, evaluated safety and efficacy of a bilateral hypoglossal nerve stimulation device for treatment of obstructive sleep apnea. (Source: Healio)

Newspaper Profiles Man with Movement Disorder Who Received Neurostimulation Therapy

Feb. 13, 2020 - An article features a Parkinson's disease patient in Vancouver, B.C. whose function and quality of life improved after he received a deep brain stimulation system. (Source: Vancouver Sun)

Results Presented of Clinical Trial Using Evoked Compound Action Potentials to Adjust Spinal Cord Stimulation

Feb. 13, 2020 - The 12-month results of a randomized, double-blind trial of closed-loop spinal cord stimulation for chronic pain were reported during the annual scientific meeting of the North American Neuromodulation Society. (Source: NeuroNews)

Study Provides Preclinical Evidence of Brain Stimulation During Unconscious State

Feb. 12, 2020 - Researchers from the University of Wisconsin reported research in primates in which electrical brain stimulation to the central lateral thalamus was able to arose them from a deep unconscious state induced by deep anesthesia. (Source: Wisconsin State Journal)

Analysis Pools Evidence of Smoking in Spinal Cord Stimulation Patients

Jan. 28, 2020 - A review documents the prevalence of smoking in patients with spinal cord stimulators, which can adversely impact pain-related outcomes. (Source: Regional Anesthesia & Pain Medicine)

Case Study: Advice on Perioperative Management of Spinal Cord Stimulators

Feb. 10, 2020 - In the context of a case study, two co-authors present advice about the perioperative management of spinal cord stimulators (SCS) and implantable pulse generators to minimize the risk of the SCS losing functionality when patients undergo procedures for other issues. (Source: Pain Medicine)

Clinical Trial in Spain Concerns a Potential Visual Prosthetic that Stimulates the Visual Cortex

Feb. 6, 2020 - An article focused on the first participant of a clinical trial in Spain explains research there to develop a visual prosthetic system that provides visual information from an eye-gear-mounted camera system to the visual cortex. (Source: MIT Technology Review)

Researchers Pursue Development of a Stretchable Polymer Battery

Feb. 5, 2020 - A research lab at Stanford University is developing a solid, but stretchable, polymer battery that might be used in body-worn sensors or medical device applications. (Source: Today's Medical Developments)

Researchers Issue a Guide About Supervised Home Use of Transcranial Direct Current Stimulation

Feb. 10, 2020 - Researchers have produced a guide concerning the supervised use of transcranial direct current stimulation at home for clinical research and practice. (Source: Brain Stimulation)

Author Summarizes Status of Varied Deep Brain Stimulation Targets Studied in Treatment-Resistant Obsessive Compulsive Disorder

Feb. 10, 2020 - The status of deep brain stimulation (DBS) in refractory obsessive compulsive disorder (OCD), and descriptions and rationale regarding six stimulation targets, were covered in an overview article. The article states that fewer than 300 patients with OCD have had DBS, which in the U.S. received an FDA Humanitarian Device Exception clearance. The author notes that most of these patients receiving the treatment participate in clinical trials due to insurance coverage issues. (Source: Psychiatry Advisor)

Randomized Trial Compares Neurostimulation to Medical Treatment Alone in Patients with Advanced Parkinson's Disease

Feb. 7, 2020 - A paper presents 12-month results in a randomized trial in 25 patients with advanced Parkinson's disease that compared deep brain stimulation in the caudal zona incerta versus best medical treatment. (Source: Journal of Neurosurgery)

12-Month Results Published for Prospective, Open-Label Study of Closed Loop Spinal Cord Stimulation

Feb. 5, 2020 - A team of co-authors published 12-month results regarding 50 patients who were implanted with a closed-loop spinal cord stimulation system to treat chronic pain in a prospective, open-label study. (Source: Neurosurgery)

Parkinson's Disease Patient in Germany Receives Recently Approved Deep Brain Stimulation System

Feb. 6, 2020 - The neurosurgical department of the LMU University Hospital in Munich announced that in January it was the first center to implant a Parkinson's disease patient with a deep brain stimulation system, recently approved in the European Union, which records brain signals to personalize the therapy and optimize stimulation delivery. (Source: IDW)

Study: Glutamate as a Potential Biomarker of Response, in Patients with Depression, to Deep Brain Stimulation

April 2020 - In 16 patients with treatment-resistant depression, researchers measured baseline glutamate in the rostral anterior cingulate and checked if that was predictive of response at six months to deep brain stimulation to the subcallosal cingulate. (Source: Journal of Affective Disorders)

Annual Call for Award Applications Opens for Early-Stage Neuromodulation Investigators

February 2020 - The Science & PINS Prize is accepting applications by March 15, 2020 from junior investigators who have performed research in neuromodulation. The competition awards $25,000 and publishes the winner's research essay in the journal Science. The runner-up's essay is also published in Science. (Source: Science)

Noninvasive Brain Stimulation Study Explores Cortical Response

Jan. 31, 2020 - A study in healthy volunteers investigates how the physiological effects of noninvasive brain stimulation differ across the human cortex. (Source: Science Advances)

Multicenter Study Compares Medical Management and Spinal Cord Stimulation in Painful Diabetic Neuropathy

Feb. 4, 2020 - A presentation at the North American Neuromodulation Society (NANS) reported on an ongoing randomized controlled trial of spinal cord stimulation at 10kHz in painful diabetic neuropathy. (Source: NeuroNews)

Column Presents Neuromodulation as a Therapy Option to Manage Chronic Migraine

Feb. 4, 2020 - A column by a physician introduces neuromodulation as one recently emerging therapy option to help manage migraine, and suggests that patients could ask their physicians about different non-pharmaceutical treatments for migraine, since there are now a variety of options. The author says neuromodulation exemplifies the extent of progress being made in migraine management. (Source: Yahoo! Lifestyle)

Heart Failure Neuromodulation Device Implanted in the United States

Feb. 3, 2020 - A medical center in New Jersey announced it is the first U.S. location to implant a neuromodulation device for congestive heart failure, Barostim Neo. (Source: Yahoo! Finance)

Researchers Investigate Brain Stimulation for Chronic Pain

Feb. 3, 2020 - Researchers began a clinical trial in October with funding from National Institutes of Health to directly observe how the brains of chronic pain patients represent their pain. The study may help to improve deep brain stimulation as a possible therapy for chronic pain, by potentially suggesting therapeutic neurostimulation targets and tracking neural response in order to automatically adjust stimulation levels. (Source: UCSF)

Documentary Features Functional Electrical Stimulation

Jan. 30, 2020 - A news story features the Cleveland FES Center, whose work creating functional electrical stimulation systems for people with functional deficits, such as quadriplegia, was included in the documentary "I Am Human". (Source: Freshwater Cleveland)

The Case for Establishing Neuromodulation Centers of Excellence

Jan. 30, 2020 - An opinion article by Robert Levy, MD, PhD, the President of the International Neuro­modulation Society and Editor-in-Chief of Neuromodulation: Technology at the Neural Interface, presents a strong case for establishing neuromodulation centers of excellence. (Source: Neuro News)

Following a Scientific Meeting, an Analyst Recaps Spinal Cord Stimulation Developments

Jan. 27, 2020 - An industry analyst provided an overview of developments from different spinal cord stimulation companies that were reported during the recent annual scientific meeting of the North American Neuromodulation Society (NANS). (Source: MD+DI)

Deep Brain Stimulation System Receives FDA Approval for an Additional Brain Target in Parkinson's Disease

Jan. 24, 2020 - Abbott announced the FDA has approved using its deep brain stimulation system to target the globus pallidus interna to manage medication-resistant motor symptoms of Parkinson's disease. (Source: MD+DI)

Study Results Presented Concerning Spinal Cord Stimulation in Chronic Pain

Jan. 23, 2020 - Abbott announced results presented at the North American Neuromodulation Society annual meeting about two prospective studies of its spinal cord stimulation system in people in chronic pain. (Source: Biospace)

Device Maker Announces Scientific Presentations Concerning Its Spinal Cord Stimulation System

Jan. 22, 2020 - Nevro Corp. announced there will be a series of data presentations at the North American Neuromodulation Society annual meeting this week in Las Vegas concerning the company's spinal cord stimulation system for chronic pain. (Source: PR Newswire)

Company Begins Proof-of-Concept Studies in Human Subjects

Jan. 22, 2020 - Soin Neuroscience announced the start of early stage proof-of-concept studies in human subjects for the spinal cord stimulation device that the company is developing for chronic pain. (Source: P&T Community)

Company Announces Presentation of Spinal Cord Stimulation Studies

Jan. 21, 2020 - Saluda Medical Pty Limited announced that multiple studies of its spinal cord stimulation system for treatment of chronic pain will be presented during the annual meeting of the North American Neuromodulation Society. Neurology Advisor also published a summary of recent findings. (Source: PR Newswire)

Three-month Results Released from Randomized Controlled Trial Comparing Spinal Cord Stimulation Modes

Jan. 21, 2020 - Medtronic plc announced three-month results from a randomized controlled trial of differential target multiplexed spinal cord stimulation (SCS) compared to conventional SCS, adding that the results will be presented at the annual meeting of the North American Neuromodulation Society. (Source: Globe Newswire)

Case Series Published Concerning Peripheral Nerve Stimulation in Low Back Pain

Jan. 21, 2020 - SBR Therapeutics announced publication of a prospective case series concerning its peripheral nerve stimulation system in the treatment of low back pain. (Source: NeuroNews)

Research Center Formed by Universities in Australia and China

Jan. 15, 2020 - The University of Queensland in Australia and the Southern University of Science and Technology in China established a joint Centre for Neuroscience and Neural Engineering to formalize a partnership in which surgeons from Shenzhen had been trained in neuromodulation in Queensland. The collaboration will continue with research into neural protection and repair following stroke, and improved neuromodulation techniques for movement disorders and neurological conditions. (Source: University of Queensland)

Brain Study Suggests Basis of Essential Tremor and Potential Target for Neuromodulation

Jan. 15, 2020 - A study of structural differences in the brains of people with essential tremor suggests a brain-activity cause for the condition. The research could open possibilities to reduce tremor, potentially, for instance, with noninvasive types of neuromodulation using activity in that particular brain region as a guide, according to the paper's senior author. (Source: Columbia University Irving Medical Center)

Retrospective Article Considers Issues and Advances in Neurotechnology Development

January 2020 - A year-in-review column about developments in 2019 in the neurotechnology field identifies some challenges that have remained over the past decade concerning issues such as clinical trial design of control arms and obtaining reimbursement for emerging therapies. (Source: Neurotech Reports)

Column Discusses Non-Opioid Intrathecal Pain Relief

Jan. 14, 2020 - An opinion article discusses intrathecal ziconotide in the management of chronic non-cancer pain. (Source: Expert Opinion on Pharmacotherapy)

Researcher Analyzes Factors Influencing Development of Neural Interface Technologies

Jan. 8, 2020 - A viewpoint article discusses factors affecting translational research and development of neural technology, particularly, previously approved or emerging implantable devices and functional electrical stimulation systems. (Source: Neuron)

Company's Sacral Neuromodulation System Receives Marketing Clearance in Europe

Jan. 13, 2020 - Medtronic received CE mark clearance introduce its micro neurostimulator and leads for sacral neuromodulation therapy to treat overactive bladder, fecal incontinence, and non-obstrctive urinary retention. (Source: Medgadget)

CE Mark Announced for Deep Brain Stimulation System with Recording Capability

Jan. 9, 2020 - Medtronic has received CE mark approval in Europe for a deep brain stimulation system that can record brain signals. The company said the first implantations will begin next week in western Europe. (Source: Fierce Biotech)

Implantable Vagus Nerve Stimulation Generator is Subject to an FDA Recall in the United States

Dec. 23, 2019 - LivaNova is recalling its implantable vagus nerve stimulation SenTiva Generator System following reports of 14 reset errors that caused it to stop delivering therapy. Four patients required revision surgery to replace the generator. Since mitigation steps were taken July 31, the company said no additional reset errors were reported. The FDA identified the recall, initiated on Aug. 22, as Class I. Patients whose device resets, or who experience a loss of stimulation or an increase in symptoms, are advised to immediately contact a healthcare provide to determine if a replacement is needed. The recall affects 2,909 devices in the United States; the devices that failed did so within 60 days of the start of therapy, according to the FDA. (Source: MedTech Dive)

Device Company Acquires Developer of Differential Target Multiplexed Spinal Cord Stimulation

Jan. 9, 2020 - Medtronic announced it has acquired Stimgenics, a privately held company that developed differential target multiplexed spinal cord stimulation based on studies of neural-glial interactions. Three-month results of an ongoing randomized controlled trial in chronic pain are slated for presentation at the 23rd North American Neuromodulation Society annual meeting this month in Las Vegas. (Source: NeuroNews)

Neurostimulator Receives Marketing Approval in Europe for Treatment of Fecal Incontinence

Jan. 6, 2020 - BioNess announced it has received CE mark approval for its implantable tibial nerve stimulator for the treatment of fecal incontinence. (Source: Mass Device)

Television News Segment Features Clinical Trial of Neurostimulation as a Potential Treatment for Addiction

Jan. 6, 2020 - In a medical television news segment, a Pittsburgh, PA station featured the clinical trial of deep brain stimulation to the nucleus accumbens as an investigative potential therapy for treatment-resistant addiction. (Source: KDKA)

Workshop Invites Applicants to Explore Modeling and Simulation of Peripheral Neuromodulation to Regulate Organ Function

Jan. 1, 2020 - The IT'IS Foundation, with funding from the National Institutes of Health, is seeking applicants by Jan. 31 for a 5-day Ideas Lab in April to develop solutions for predictive modeling of peripheral neuromodulation to regulate organ function. (Source: SPARC Science)

Meta-Analysis Investigates Effectiveness of Placebo Vs. Spinal Cord Stimulation

Jan. 1, 2020 - A meta-analysis of spinal cord stimulation (SCS) trials introduces a potentially generalizable differentiation between placebo and sham concepts and investigates the effectiveness of SCS when compared with placebo. (Source: Pain)