The International Neuromodulation Society

The Fastest-Growing, Worldwide Multidisciplinary Body Devoted to Building Knowledge of Neuromodulation

The International Neuromodulation Society (INS) is a non-profit group of clinicians, scientists and engineers dedicated to the scientific development and awareness of neuromodulation – the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body. The San Francisco-based INS was formed in 1989 and educates and promotes the field through meetings, its peer-reviewed journal Neuromodulation: Technology at the Neural Interface, mentorship, and chapter websites. The INS also provides information for patients and produces rolling news briefs about this rapidly evolving field.

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The INS Peer-Reviewed Journal

The INS journal Neuromodulation: Technology at the Neural Interface has a growing Impact Factor and is indexed in Index Medicus, MEDLINE and Pubmed from its first issue in 1998. Members may log in to the members-only section to read the journal online. The journal also has social media accounts on Twitter, Facebook, and Instagram.

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The Neuromodulation Podcast has been developed for our membership to dive into the forefront of today's emerging neuromodulation techniques, insights, and ethical and clinical applications.

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What is Neuromodulation?

Medical Professionals can learn about various considerations concerning neuromodulation and clinic contacts. Once your preliminary questions have been answered, please use the Contact Us facility to find out more and to discuss specific objectives. Others may simply wish to join the INS and one of its related chapter societies, please use the Membership Application.

Clinical trials that involve a wide range of emerging neuromodulation approaches are listed on our Research page. Neuromodulation clinical trials address symptom control through nerve stimulation in such condition categories as:

Chronic pain
Movement disorders
Epilepsy
Psychiatric disorders
Brain injury / Stroke 
Cardiovascular disorders
Gastrointestinal disorders
Genitourinary and colorectal disorders
Sensory deficits


If you are not a medical professional
and you are searching for information about neuromodulation and how these types of treatment could benefit a specific condition such as treatment-resistant headache or other chronic pain syndromes, you may find the sections titled Therapies, About Neuromodulation or FAQs particularly helpful.

Breaking News

Tongue-Based Neuromodulation Shows Promise for Improving Balance After Brain Injury

May 30, 2026 - A neuromodulation therapy that delivers electrical stimulation through the tongue is being used alongside rehabilitation exercises to improve balance and gait impairments associated with traumatic brain injury and other neurological conditions. The approach targets cranial nerve pathways connected to the brainstem and cerebellum and has received regulatory clearance for treating chronic balance deficits after brain injury. Ongoing clinical research is evaluating its role as a noninvasive tool to support neurorehabilitation and functional recovery. (Source: Psychology Today)  

First Chronic Clinical Trial of Fully Implantable Brain–Computer Interface Approved for ALS Patients

Researchers in the Netherlands have received regulatory approval to begin a clinical trial evaluating a fully implantable brain–computer interface in people with amyotrophic lateral sclerosis (ALS). The study will assess the long-term safety and performance of the system, with a focus on restoring communication and speech capabilities in everyday home settings. The trial represents an early step toward testing implantable brain–computer interfaces for real-world use outside controlled research environments. (Source: MSN)  

Neuromodulation Linked to Restoration of Brain Network Dynamics in Parkinson’s Disease

April 20, 2026 - A brain imaging study in Parkinson’s disease shows that deep brain stimulation of the subthalamic nucleus is associated with a normalization of large-scale cortical network dynamics linked to motor function. Using advanced fMRI-based analysis, researchers identified altered patterns of brain state transitions that were restored alongside symptom improvement during stimulation. Similar effects were also observed with a noninvasive neuromodulation approach, suggesting shared network-level mechanisms across different stimulation techniques. (Source: Nature)  

Review Outlines Progress and Challenges in Implantable Bioelectronic Systems

April 11, 2026 - A new perspective in Nature Communications reviews advances in implantable bioelectronic technologies that integrate physiological sensing with therapeutic stimulation for organ-level disease management. It highlights emerging approaches such as soft biomaterials, optogenetic methods, and closed-loop control, alongside ongoing challenges in safety, stability, and clinical translation. The authors discuss how continued development may support more targeted and adaptive medical interventions in the future. (Source: Nature)  

Targeted Brain Stimulation Shows Strong Results for PTSD in Military Study

April 8, 2026 - A study published in JAMA Network Open found that MRI-guided transcranial magnetic stimulation combined with psychotherapy led to significant symptom improvement in 85% of military personnel and veterans with severe PTSD, compared to 59% with psychotherapy alone. The approach uses individualized brain targeting to enhance treatment effectiveness and showed more sustained benefits over time. (Source: Reuters)  

To see select neuromodulation news by category, as well as news about the INS in particular, please visit the Newsroom. To see archived news briefs dating back to January 2011, visit the News Archive.

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