The International Neuromodulation Society

The Fastest-Growing, Worldwide Multidisciplinary Body Devoted to Building Knowledge of Neuromodulation

The International Neuromodulation Society (INS) is a non-profit group of clinicians, scientists and engineers dedicated to the scientific development and awareness of neuromodulation – the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body. The San Francisco-based INS was formed in 1989 and educates and promotes the field through meetings, its peer-reviewed journal Neuromodulation: Technology at the Neural Interface, mentorship, and chapter websites. The INS also provides information for patients and produces rolling news briefs about this rapidly evolving field.

Novel Coronavirus / COVID-19 Resources

The INS Peer-Reviewed Journal

The INS journal Neuromodulation: Technology at the Neural Interface has a growing Impact Factor and is indexed in Index Medicus, MEDLINE and Pubmed from its first issue in 1998. Members may log in to the members-only section to read the journal online. The journal also has social media accounts on Twitter, Facebook, and Instagram.

journal cover

+Submit a Manuscript.+

What is Neuromodulation?

Medical Professionals can learn about various considerations concerning neuromodulation and clinic contacts. Once your preliminary questions have been answered, please use the Contact Us facility to find out more and to discuss specific objectives. Others may simply wish to join the INS and one of its related chapter societies, please use the Membership Application.

Clinical trials that involve a wide range of emerging neuromodulation approaches are listed on our Research page. Neuromodulation clinical trials address symptom control through nerve stimulation in such condition categories as:

Chronic pain
Movement disorders
Psychiatric disorders
Stroke / brain injury
Cardiovascular disorders
Gastrointestinal disorders
Genitourinary and colorectal disorders
Sensory deficits

If you are not a medical professional
and you are searching for information about neuromodulation and how these types of treatment could benefit a specific condition such as treatment-resistant headache or other chronic pain syndromes, you may find the sections titled Therapies, About Neuromodulation or FAQs particularly helpful.

Members may log in and visit the members-only section’s Global Discussion Forum

Breaking News

Study Shows Higher Survival Rates for Pediatric Patients with Drug-Resistant Epilepsy Treated with Surgery or Vagus Nerve Stimulation

June 2, 2023 - A recent observational cohort study comparing treatment options for pediatric patients with drug-resistant epilepsy found that those who underwent cranial epilepsy surgery or received vagus nerve stimulation (VNS) had higher survival rates compared to those who received only medical treatment. (Source: The Lancet)

Adolescent Neurostimulation of Dopamine Circuit Shows Potential for Treating Neuropsychiatric Disorders

June 2, 2023 - Researchers at the University of Rochester used neurostimulation during critical developmental windows to target underperforming dopamine neurons in mice, leading to long-lasting changes that corrected structural brain deficiencies associated with neuropsychiatric disorders like schizophrenia and autism. This suggests the potential for interventions during specific developmental periods to alter the course of these disorders. (Source: Neuroscience News)

Study Reveals Brain's Memory Consolidation Process During Sleep

June 1, 2023 - New research demonstrates how the brain consolidates memories during sleep by stimulating specific brain regions. The study's brain stimulation technique shows potential for future advancements in memory research and therapeutic interventions. (Source: USA Today)

Computational Models Predict Vagus Nerve Stimulation Thresholds in Preclinical Animals and Humans

May 31, 2023 - Validated computational models, utilizing ASCENT software, accurately simulate the effects of vagus nerve stimulation (VNS) in humans, pigs, and rats. The models incorporate various factors such as nerve histology, device design, tissue conductivities, and realistic fiber models, successfully predicting activation thresholds for different species and fiber types. The study highlights the potential of these models in understanding the therapeutic and side effects of VNS and individual-specific variations in neural responses. (Source: IOP Science)

Interview Features Physician's Insights Microburst Vagus Nerve Stimulation for Drug-Resistant Epilepsy

May 31, 2023 - In an interview, Dr. Cornelia Drees, a senior associate consultant in the Department of Neurology at Mayo Clinic, highlights the potential of microburst vagus nerve stimulation (VNS) as a targeted treatment for drug-resistant epilepsy. Microburst VNS differs from traditional VNS by delivering stimulation at higher frequencies in short bursts, showing promising results in reducing seizure frequency and improving quality of life in patients. (Source: NeurologyLive)

Engineers Develop Flexible Nanoelectrodes for Fine-Grained Brain Stimulation

May 30, 2023 - Rice University engineers have created ultraflexible nanoelectrodes that can be implanted in the brain for long-term, high-resolution stimulation therapy. The devices exhibit high biocompatibility and precise control over stimulus patterns, offering potential for sensory prostheses and improved treatment for conditions such as Parkinson's disease, epilepsy, and obsessive-compulsive disorder (OCD). (Source: Science News)

Nerve Stimulation Shows Promise in Tobacco De-addiction

May 30, 2023 - Dr. M.S. Reddy, a psychiatrist, has introduced a non-invasive neuromodulation treatment using deep transcranial magnetic stimulation (TMS) to help tobacco users quit their addiction. The treatment has shown success in 27 out of 60 patients, with others significantly reducing tobacco use. (Source: Deccan Chronicle)

Interview Addresses DARPA's Brain Hacking Experiment: Transforming a Science Writer into a Precision Shooter

May 29, 2023 - In a conversation with journalist Rose Eveleth, former editor of IEEE Spectrum, Sally Adee, discusses the potential implications of transcranial direct current stimulation (tDCS) technology. Adee touches upon concerns about the democratization of tDCS, the risks of self-experimentation, the limited understanding of its efficacy, the ethical considerations in sports and the workplace, and the need to approach emerging bioelectricity research, including tDCS, with clear eyes, avoiding the tendency to fit it into pre-existing narratives. (Source: Bulletin of the Atomic Scientists)

FDA Clears Company’s Micro-Implant Neurostimulation System for Chronic Peripheral Nerve Pain Treatment

May 29, 2023 - The FDA has granted clearance to Neuspera's micro-implant neurostimulation system, making it the first ultra-miniaturized peripheral nerve stimulation device approved for treating chronic peripheral nerve pain. The wireless platform, including a wearable transmitter and iPad-based clinician programmer, offers improved patient experience and procedural flexibility, allowing physicians to target deeper anatomical sites for pain relief. (Source: Pain Medicine News)

Wireless Brain-Computer Interface Enables Thought-Controlled Movement in Spinal Cord Injury Patients

May 27, 2023 - A study in Nature demonstrates the potential of a wireless brain-computer interface (BCI) paired with ARC Therapy to restore thought-controlled movement in individuals with spinal cord injury (SCI). The BCI establishes a continuous link between movement intentions and spinal cord stimulation, allowing for more natural mobility restoration. The ongoing clinical feasibility study shows promising safety and preliminary effectiveness in brain-controlled spinal cord stimulation after SCI. (Source: News Medical)

Analysis of Brain Stimulation Studies Explores Efficacy in Enhancing Memory and Focus

May 26, 2023 - A comprehensive analysis of over 100 studies on transcranial alternating current stimulation (tACS) and, suggests that these methods can lead to moderate improvements in attention, memory, problem-solving, and other cognitive processes. However, some researchers argue that the diverse nature of the studies makes it difficult to draw definitive conclusions. (Source: Nature)

Deep Brain Stimulation of Anterior Nucleus of the Thalamus Shows Efficacy in Drug-Resistant Epilepsy

May 26, 2023 - A study published in Neurology presents the results of the Medtronic Registry for Epilepsy (MORE), which assessed the safety and effectiveness of deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) in patients with drug-resistant epilepsy. The study showed a significant reduction in seizure frequency and a responder rate consistent with previous clinical trials. However, adverse events such as changes in seizure patterns, memory impairment, and depressive mood were reported, underscoring the need for careful monitoring during DBS therapy. (Source: Physicians Weekly)

Neuralink Receives FDA Approval for First In-Human Clinical Study of Brain Implant Technology

May 26 2023 - Neuralink, Elon Musk's neurotech startup, has gained FDA approval for its first in-human clinical study, allowing it to move forward with testing its brain implant called the Link, which aims to help patients with severe paralysis control external technologies using neural signals. (Source: CNBC)

Article Shares Patient Experience of Brain-Spine Interface That Enabled Natural Walking After Spinal Cord Injury

May 24, 2023 - As featured in Nature, researchers developed a brain-spine interface (BSI) that restored communication between the brain and the spinal cord in a person with chronic tetraplegia, allowing them to stand and walk naturally. The BSI, which consists of implanted recording and stimulation systems, facilitated control over leg movements and improved neurological recovery, offering a framework for restoring movement in individuals with paralysis. (Source: Science)

Head-Worn Device Utilizes Machine Learning and Brain Imaging to Differentiate Hand Gestures

May 23, 2023 - Researchers at the University of California San Diego have developed a head-worn wearable device that uses machine learning and magnetoencephalography (MEG) to differentiate hand gestures. The device achieved over 85% accuracy in distinguishing gestures in a trial. This technology has the potential to assist individuals with paralysis or amputated limbs in controlling devices using their minds. (Source: Health IT Analytics)

Breakthrough in Decoding Brain Signals Reveals Objective Biomarker for Chronic Pain

May 22, 2023 - For individuals with intractable chronic pain, researchers have successfully decoded brain activity underlying chronic pain for the first time. The findings may have an impact on deep brain stimulation clinical trials. The study identified brain regions associated with pain and developed an algorithm to predict pain levels based on electrical signals in the brain, which may provide opportunity for personalized therapies. (Source: Guardian)

Study Addresses Accelerated TMS for Faster Relief of Depression Symptoms

May 22, 2023 - Accelerated transcranial magnetic stimulation (TMS) protocols have shown potential for reducing treatment duration and improving response time in major depressive disorder (MDD). This study reviews nine elements around accelerated TMS including treatment parameters, cumulative exposure, individualized parameters, and brain state. (Source: Nature)

Vagal Nerve Stimulation Explored as Potential Treatment for New-Onset Refractory Status Epilepticus

May 21, 2023 - Researchers propose the consideration of vagal nerve stimulation (VNS) as a well-tolerated intervention for new-onset refractory status epilepticus (NORSE). Although limited evidence exists, VNS shows potential in reducing seizure burden and modulating ictogenesis, highlighting the need for further investigation through clinical trials. (Source: AJMC)

Deep Brain Stimulation Shows Cost-Effectiveness and Clinical Efficacy for Advanced Parkinson's Disease

May 19, 2023 - A prospective study of 73 adults conducted in Vietnam compared deep brain stimulation (DBS) surgery to medical therapy in patients with advanced Parkinson's disease (PD). The study found that DBS was more cost-effective and improved motor function, reducing "off" time and dyskinesia in patients. (Source: Healio)

Stanford Study Reveals How Transcranial Magnetic Stimulation Treats Depression

May 18, 2023 - A Stanford study has found that transcranial magnetic stimulation (TMS) treats depression by reversing the direction of abnormal brain signals. Backward streams of neural activity between specific areas of the brain were highlighted as a potential biomarker to diagnose depression. (Source: Neurology Live)

Article Shares First Person Experience in Study for Spinal Cord Injury Recovery

May 18, 2023 - An news story covers a news anchor who is part of a research study at the University of Louisville. The study uses epidural stimulation to help individuals with spinal cord injuries regain muscle control and independence, showing promising progress in the patient’s ability to stand and improve mobility. (Source: WISN)

Tactile Stimulation at 40 Hz Frequency Shows Promise in Alzheimer's Treatment

May 18, 2023 - Researchers have found that daily exposure to tactile stimulation at a frequency of 40 Hz can reduce Alzheimer's disease pathology and improve motor function. The study conducted on Alzheimer's model mice demonstrated a decrease in phosphorylated tau levels, protection against neuronal damage and synaptic loss. This discovery suggests the potential for non-invasive therapeutic strategies in treating neurodegenerative diseases like Alzheimer's. (Source: Neuroscience News)

FDA Approves Spinal Cord Stimulation Devices for Non-Surgical Back Pain

May 16, 2023 - Abbott received FDA approval for its entire portfolio of spinal cord stimulation (SCS) devices for patients with chronic back pain who have not had or are ineligible for surgery. This approval includes the recharge-free Proclaim SCS family and the rechargeable Eterna SCS platform. (Source: MassDevice)

First-in-Human Use for Spinal Cord Injury Patients Shows Promising Results

May 15, 2023 - ONWARD Medical has achieved a successful first-in-human use of their ARC-IM Lead, delivering targeted electrical pulses to the spinal cord. The lead's unique design and electrode placement offer potential benefits for blood pressure regulation in individuals with spinal cord injury. (Source: Yahoo Finance)

Smart Earpiece May Accelerate Stroke Recovery by Stimulating Neural Circuits

May 15, 2023 - Researchers from ETH Zurich have developed a smart earpiece that stimulates the vagus nerve to accelerate stroke recovery. The non-invasive system eliminates the need for surgery and promotes neuroplasticity by timing electrical impulses during specific motor actions. A movement sensor tracks progress, and remote monitoring is possible via a smartphone app. The first clinical study is impending. (Source: Today’s Medical Developments)

Transcutaneous Auricular Vagus Nerve Stimulation is a Potential Novel Treatment for Polycystic Ovary Syndrome   

May 12, 2023 - This study targets parasympathetic modulation via non-invasive transcutaneous auricular vagal nerve stimulation (ta-VNS) and suggests that this procedure is promising as a treatment or supplementary treatment for polycystic ovary syndrome (PCOS). (Source: Nature)

Study Indicates PET Imaging Reveals Brain Stimulation's Effects in Coma Patients

May 11, 2023 - A study utilizing PET imaging has shown that trigeminal nerve stimulation (TNS) can increase brain metabolism in key cognitive areas and potentially promote recovery in patients with disorders of consciousness. The findings support the use of TNS as a promising intervention for coma awakening and demonstrate the effectiveness of FDG-PET as an objective evaluation tool in assessing brain function in these patients (Source: Brain Stimulation)

Spinal Cord Stimulation System Receives Expanded FDA Approval for MRI Labeling

May 11, 2023 - Abbott has received expanded FDA MRI labeling for its Eterna pain relief device. (Source: Seeking Alpha)

Implantable Tibial Neuromodulation Therapy for Overactive Bladder Shows Promising Results

May 10, 2023 - OASIS, a 151-patient open-label clinical study demonstrated statistically significant improvement in reduction in urgency urinary incontinence, including urinary urgency and urinary frequency. Results are under review by the FDA. (Source: Yahoo! Finance)

To see select neuromodulation news by category, as well as news about the INS in particular, please visit the Newsroom. To see archived news briefs dating back to January 2011, visit the News Archive.

Continue Reading News Briefs