The International Neuromodulation Society

The Fastest-Growing, Worldwide Multidisciplinary Body Devoted to Building Knowledge of Neuromodulation

The International Neuromodulation Society (INS) is a non-profit group of clinicians, scientists and engineers dedicated to the scientific development and awareness of neuromodulation – the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body. The San Francisco-based INS was formed in 1989 and educates and promotes the field through meetings, its peer-reviewed journal Neuromodulation: Technology at the Neural Interface, mentorship, and chapter websites. The INS also provides information for patients and produces rolling news briefs about this rapidly evolving field.

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The INS Peer-Reviewed Journal

The INS journal Neuromodulation: Technology at the Neural Interface has a growing Impact Factor and is indexed in Index Medicus, MEDLINE and Pubmed from its first issue in 1998. Members may log in to the members-only section to read the journal online. The journal also has social media accounts on Twitter, Facebook, and Instagram.

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The Neuromodulation Podcast has been developed for our membership to dive into the forefront of today's emerging neuromodulation techniques, insights, and ethical and clinical applications.

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What is Neuromodulation?

Medical Professionals can learn about various considerations concerning neuromodulation and clinic contacts. Once your preliminary questions have been answered, please use the Contact Us facility to find out more and to discuss specific objectives. Others may simply wish to join the INS and one of its related chapter societies, please use the Membership Application.

Clinical trials that involve a wide range of emerging neuromodulation approaches are listed on our Research page. Neuromodulation clinical trials address symptom control through nerve stimulation in such condition categories as:

Chronic pain
Movement disorders
Epilepsy
Psychiatric disorders
Brain injury / Stroke 
Cardiovascular disorders
Gastrointestinal disorders
Genitourinary and colorectal disorders
Sensory deficits


If you are not a medical professional
and you are searching for information about neuromodulation and how these types of treatment could benefit a specific condition such as treatment-resistant headache or other chronic pain syndromes, you may find the sections titled Therapies, About Neuromodulation or FAQs particularly helpful.

Breaking News

Researchers Developed BCI That Translates Inner Speech in Real Time

August 14, 2025 - Researchers at Stanford University developed a brain-computer interface (BCI) that can decode imagined speech in people with ALS or stroke-related paralysis. The system enables translation of internal verbal thoughts into sentences with 74% accuracy using neuronal recordings from the motor cortex. While effective for structured tasks, spontaneous thought decoding remains limited, and privacy safeguards are included to prevent unintentional access to private thoughts. (Source: The Scientist)

Study Links Depression Symptoms to Shifts in Prefrontal Brain Activity

August 6, 2025 - A new study published in Nature Communications shows that fluctuations in depression symptoms are tied to low-frequency communication and hemispheric imbalances in the prefrontal cortex. The findings support theories that depression involves disrupted inhibitory control in brain networks and could guide the development of personalized neuromodulation therapies like adaptive deep brain stimulation. (Source: PsyPost)

AI-Driven Models Help Personalize Deep Brain Stimulation to Improve Walking in Parkinson’s

August 5, 2025 - Researchers from University of California, San Francisco (UCSF) used mathematical models and AI to predict personalized deep brain stimulation (DBS) settings that improved gait in people with Parkinson’s disease. The study showcased that tailoring DBS based on individual brain activity could improve walking performance, pointing toward more effective, individualized therapies. (Source: Parkinson's News Today)

FDA Approves Vagus Nerve Stimulator for Rheumatoid Arthritis Treatment

July 31, 2025 - The FDA has approved a vagus nerve stimulation device developed by SetPoint Medical for treating moderate-to-severe rheumatoid arthritis in patients unresponsive to biologic or targeted synthetic DMARDs. Implanted in the neck and activated for one minute daily, the device showed clinical benefits in a year-long trial, with plans for U.S. commercialization beginning in select US cities in late 2025. (Source: Medscape)

Advances in Neuromodulation Techniques for Parkinson’s Disease Treatment

July 30, 2025 - Advancements in invasive and non-invasive neuromodulation techniques, including Deep Brain Stimulation (DBS), transcranial stimulation, and focused ultrasound, are expanding treatment options for Parkinson’s disease by targeting both motor and non-motor symptoms. Emerging technologies like temporal interference, gene therapy, and nanoparticle-assisted drug delivery point toward a future of more personalized and adaptive therapies, though further clinical research is needed to confirm their long-term effectiveness. (Source: npj Parkinson's Disease)

Vagus Nerve Stimulation Device Boosts Fitness Tolerance in Early Trial

July 28, 2025 - A study published in the European Heart Journal found that using a vagus nerve stimulator for 30 minutes daily over one week improved oxygen uptake, heart rate, and breathing rate during exercise in healthy individuals. The device also reduced inflammation markers in the blood. According to researchers, the findings could pave the way for new therapies to help people with heart conditions improve their physical activity and well-being, pending further trials. (Source: Medical Xpress)

To see select neuromodulation news by category, as well as news about the INS in particular, please visit the Newsroom. To see archived news briefs dating back to January 2011, visit the News Archive.

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