2017 News Briefs - International Neuromodulation Society

Earlier News:


January - June 2017

Article Recaps Brain-Computer Interface Progress

June 19, 2017 - A feature article summarizes the state of brain-computer interface research projects, noting that while devices are far from everyday use, they are beginning to help people who are paralyzed, and include attempts to include sensory input. (Paste Magazine)

Neuromodulation Research Database Registrants Surge After INS Congress

June 2017 - The collective database of primary neuromodulation research data, WIKISTIM, reported the largest monthly increase in registrants -- a one-month increase of more than 7% -- since the online resource was created in 2013. Its editor, International Neuromodulation Society member Jane Shipley, attributes that growth to her presentations made at the INS 13th World Congress. In the monthly newsletter, she acknowledged INS Director-at-Large Konstantin Slavin for mentioning the resource during his presentations as well. With an additional 37 registrants since May, the registered users now number 510. (WIKISTIM)

Deep Brain Stimulation Clinical Trial Addresses Affective Component of Neuropathic Pain

June 14, 2017 - International Neuromodulation Society member Andre Machado, MD, PhD, was mentioned in an article about the first prospective, randomized, controlled trial of DBS for neuropathic pain. The work was published in May 2017 in the Annals of Neurology. Co-authors included fellow INS members Scott Lempke, PhD and Kenneth Baker, PhD. In the nine patients in the cross-over trial, active stimulation did not produce at least a 50% improvement in pain disability compared to sham, but the stimulation to the ventral striatum did improve indices of the affective component of pain, such as depression, anxiety and quality of life. (Cleveland Clinic)

Spinal Cord Stimulation Improved Gait in Patients with Advanced Parkinson's Disease

June 6, 2017 - A pilot study of spinal cord stimulation in advanced Parkinson's disease, reported at the International Congress of Parkinson's Disease and Movement Disorders (MDS) 2017, showed the intervention improved freezing of gait in five patients whose gait dysfunction did not respond to levodopa. Up to 25 patients may eventually be included in the study. (Medscape)

Vagus Nerve Stimulation in Stroke Rehabilitation: Pilot Data Presented, Pivotal Clinical Trial Announced

May 31, 2017 - At the International Neuromodulation Society 13th World Congress, results of a randomized controlled pilot study were presented regarding 20 patients undergoing physical rehabilitation for stroke. Nine of the 20 patients received six weeks of vagus nerve stimulation in conjunction with intensive physical rehabilitation. The combination led to improvement in 75% of patients, compared to improvement in 33% of the 11 patients who only received physical rehabilitation. The response to the combined intervention increased to 88% at 90 days, and scores continued to increase through 9 months. At the same meeting, MicroTransponder, Inc. announced a 120-patient pivotal clinical trial http://www.vnsstroketrial.com/ of this intervention will begin enrollment this summer in the U.S. and U.K. (military-technologies.net)

Startup Plans Clinical Trial of Contact Lenses for Glaucoma

May 31, 2017 - Bionode, a Purdue University affiliated startup, plans to start a clinical trial of a contact lens designed to decrease pressure within the eye to treat glaucoma. The device includes a gold loop that receives an electromagnetic field from a special pair of glasses, which is converted into a current and delivered to a part of the eye that helps drain fluid build-up. (Journal & Courier)

Company Announces Positive Interim Results of Rechargeable Neurostimulator for Overactive Bladder

May 30, 2017 - Axonics Modulation Technologies, Inc. announced interim results of a prospective multi-center clinical study of its rechargeable sacral neuromodulation system for the treatment of overactive bladder. Of 33 patients who reached the three-month mark, 71% experienced at least a 50% decrease in symptoms, according to the results presented at the International Neuromodulation Society 13th World Congress. (Business Wire)

Company Announces $40 Million Pre-Commercial Investment

May 29, 2017 - Saluda Medical Pty Limited announced it received $40 million in a series D round of financing led by new investor Action Potential Venture Capital, a GSK fund, with previous investors participating. The funding should support clinical development of an intelligent, closed-loop spinal cord stimulation system that is undergoing a prospective, randomized, controlled, double-blinded clinical study by pain specialists at up to 20 U.S. sites. The funding will also allow the company to commercialize the therapy in Europe and Australia. (PR Newswire)

INS Announces Six Best Abstracts at the 13th World Congress

May 29, 2017 - The International Neuromodulation Society announced six best abstract awards at its 13th World Congress in Edinburgh, Scotland. The abstracts about pain and movement disorder were presented in a plenary session during the opening day of the congress. (EurekAlert)

Company Announces CE Marking for Peripheral Nerve Stimulation Anchoring System

May 26, 2017 - Freedom Neuro BV, a medical device distributor for Stimwave Technologies, announced CE mark approval for a percutaneous injectable anchor system used with Stimwave's neurostimulation devices designed to address chronic pain. (Business Wire)

Company Announces Financing for Clinical Validation of Its Stretchable Neuromodulation Lead

May 25, 2017 - WISE Srl announced EUR 6.5 million in series B financing to clinically validate its flexible, stretchable implantable neuromodulation leads for brain monitoring and spinal cord stimulation. Based on Italy with an office in Berlin, the company opened a production plant in Milan in 2016, where the leads' electrode functionality is impregnated into a polymer substrate using supersonic cluster beam implantation. (Gruenderfonds)

Small Study Suggests Transcranial Direct Current Stimulation Can Help Relieve Chronic Knee Pain

May 22, 2017 - A double-blind, randomized clinical study of 40 adults aged 50 -70 with osteoarthritis indicated that five daily sessions of transcranial direct Current stimulation lessened their pain severity. (tDCS) (Medscape)

Article Highlights Acceleration of Neuromodulation Progress

May 18, 2017 - An interview with International Neuromodulation Society President Timothy Deer, MD, prior to the INS 13th World Congress, touches upon the accelerating progress made in the field of neuromodulation. (Medtech Insight)

Company Receives $6 Million to Develop Peripheral Nerve Stimulation for Pain Relief

May 15, 2017 - SPR Therapeutics has received a second contract from the U.S. Department of Defense to use its peripheral nerve stimulation system for relief of chronic pain. Including an previous grant, the company has received nearly $9 million for research and commercialization of the therapy. (P&T Community)

Interview Surveys the Future of Neuromodulation

May 2017 - International Neuromodulation Society President Timothy Deer, MD, is interviewed about the future of neuromodulation in a publication's "Spotlight on neuromodulation". He describes devices becoming smarter so they can evaluate the response of the body and make changes in real time, as well as work in the brain to find new targets to treat diseases and conditions that are not optimally treated by pharmaceutical options. (Neuro Central)

Company Announces Its Neurostimulator's First Use in Ireland

May 9, 2017 - Mainstay Medical International plc announces its first sale and implant of its neurostimulation system to treat disabling chronic low back pain in Ireland. (Business Wire)

Long-Term Evidence Published Regarding Closed-Loop Neurostimulation in Epilepsy

May 3, 2017 - An article summarizes two recently published studies that offer long-term perspective on responsive, closed-loop, neurostimulation for the reduction of epileptic seizures. (Practical Neurology)

Sacral Neuromodulation Device Maker Raises $14.5 Million

May 2, 2017 - Axonics Modulation Technologies has raised $14.5 million toward its goal of $30 million for a series C round of financing for a pivotal study of its rechargeable sacral nerve stimulation system in overactive bladder. The clinical trial is anticipated to start in the second half of 2017 at medical centers in the U.S. and Europe. (Fierce Biotech)

Company Plans Clinical Study of Neurostimulator for Weight Loss

May 2, 2017 - According to an SEC filing, EnteroMedics Inc. will fund a clinical study of its vagus nerve stimulation implant by the Southern California Permanente Medical Group, to investigate the device as an aid for weight loss in patients who have Type 2 diabetes and obesity. (Mass Device)

International Neuromodulation Society Innovations Day Will Present 12 Emerging Companies and Organizations

April 27, 2017 - Twelve emerging companies and organizations will present their innovative therapeutic strategies at the International Neuromodulation Society's Innovations Day preconference on May 28, 2017 in Edinburgh. They are endeavoring to address such conditions as paralysis, autism, and challenging persistent pain. (International Neuromodulation Society)

Grant Supports Research into Combining Transcranial Magnetic Stimulation with Monitoring of Brain-Network Activation

April 26, 2017 - Aalto University and the University of Eastern Finland  have received a grant of €1M from the Jane and Aatos Erkko Foundation to produce a new kind of multi-channel transcranial magnetic stimulator that is compatible with fMRI and EEG methods to measure stimulation-induced neural network activation. The intent is to develop approaches to conditions such as Parkinson's disease, chronic pain, and potentially also stroke or depression. (Science Business)

U.S. Agency Announces Research Grants for Brain-Plasticity Studies

April 26, 2017 - The U.S. Department of Defense's Advanced Research Program Agency, DARPA, is funding eight projects at seven U.S. universities to study ways to potentially use peripheral nerve stimulation to facilitate brain plasticity and learning, through the Targeted Neuroplasticity Training (TNT) program. (DARPA)

Study: Transcutaneous Occipital Nerve Stimulation Lowered Migraine Intensity

April 17, 2017 - A randomized controlled clinical trial of transcutaneous occipital nerve stimulation in 110 patients with migraine found that one month of neurostimulation plus treatment with topiramate resulted in reduced headache intensity, regardless of frequency -- which was either 2 Hz, 100 Hz, or 2/100 Hz. The group that received 100 Hz stimulation plus topiramate had significant decreases in headache duration. (Pain)

FDA Approves Neurostimulator to Treat Dry Eye

April 25, 2017 - The FDA granted marketing authorization to Allergen plc for its stimulator to temporarily increase tear production in adults with dry eye. The handheld device is designed for intranasal use with disposable tips. (PR Newswire)

Non-invasive Brain Stimulation Aided Some Memory Training in Study

April 24, 2017 Researchers investigating the effects of transcranial direct current stimulation (tDCS) report that tDCS to the right dorsolateral prefrontal cortex in 12 subjects significantly improved performance on a verbal memory-training task and a related task, as well as a reasoning test. The overall research explored combinations of working memory training in groups of 70 volunteers total, with some tDCS administered to the left dorsolateral prefrontal cortex, and some to the right. Results appeared in the journal Neuropsychologia. http://www.sciencedirect.com/science/article/pii/S0028393216303852(Science Daily)

Case Series Indicates Sacral Nerve Stimulation Shows Promise for Refractory Constipation in Pediatric Patients

April 24, 2017 - The author of an abstract presented at the 2016 World Congress of Pediatric Gastroenterology, Hepatology and Nutrition concluded that sacral nerve stimulation is promising for children who have constipation that is refractory to conventional treatment. The study involved 25 patients with a mean age of 14. Despite a 25% complication rate, all patients said they would recommend the therapy to patients with similar symptoms. (Gastroenterology & Endoscopy News)

Review Summarizes Studies of Non-invasive Brain Stimulation in Spasticity Management

April 19, 2017 - Authors of a literature review about repetitive transcranial magnetic stimulation or transcranial direct current stimulation for spasticity management say most studies have been heterogenous. However, they write that published findings indicate "low-frequency rTMS and cathodal-tDCS over the unaffected hemisphere are more effective in reducing spasticity than high-frequency rTMS and anodal-tDCS over the affected hemisphere in chronic post-stroke." (PM & R)

Company Receives a Five-Year Contract to Supply its Wireless Neurostimulation System to the U.S. Department of the Defense

April 21, 2017 - Stimwave Technologies announced it received a five-year contract from the Department of Defense to supply its spinal cord stimulation system. (Mass Device)

Facing Unusual Spinal Anatomy, Physicians Use Three-Dimensional Printing to Plan a Spinal Cord Stimulation Case

April 20, 2017 - A case report in Neuromodulation: Technology at the Neural Interface describes using 3D printing to plan spinal cord stimulation for a patient whose distorted spinal anatomy had previously made access to the target location difficult. (News-Medical.net)

Researchers Predict Electrical Stimulation Aids Memory Most When Recall Wanes

April 20, 2017 - Researchers published results of a study in which they analyzed brain activity during memory tests and then developed and tested a predictive algorithm that indicates memory recall is enhanced when a stimulus is applied at a time it is faltering. The study in Current Biology was funded by the U.S. Department of Defense, through the DARPA Restoring Active Memory (RAM) program. The data were obtained during intracranial monitoring of 102 people who were undergoing epilepsy evaluation. (IEEE Spectrum)

Review Summarizes Non-Invasive Brain Stimulation Studies that Address Obesity

April 19, 2017 - A review of studies of non-invasive brain stimulation for obesity in the journal Appetite found that short studies indicated stimulating the dorsolateral prefrontal cortex appears to decrease food cravings, but the promising results are preliminary and not conclusive. (Pakistan Observer)

INS Member Discusses Data Showing Patient Satisfaction Over 7.5 Years With Spinal Cord Stimulation

April 18, 2017 - International Neuromodulation Society member Simon Thomson, MD, was interviewed about a single-center case series of 321 patients in Neuromodulation: Technology at the Neural Interface that suggests the cost-effectiveness of spinal cord stimulation may become increasingly favorable. The interview also covered a comparatively low infection rate, accomplished through meeting the recent infection-control guidelines published by the Neuromodulation Appropriateness Consensus Committee. (NeuroNews)

Portable, Hand-Held Device Receives FDA Approval to Treat Cluster Headache

April 18, 2017 - The FDA has approved a non-invasive vagus nerve stimulation device to treat episodic cluster headaches. The manufacturer, electroCore LLC, said the condition affects about 350,000 people in the U.S. (NBC)

Clinical Trial Participant with ALS Uses Her Thoughts to Type Via a Brain-Computer Interface

March 29, 2017 - International Neuromodulation Society member Jamie Henderson, MD, of Stanford University was interviewed about an ALS patient who is using the BrainGate2 interface to mentally control a cursor and type out her thoughts despite her immobility due to her condition. His university is among the collaborating institutions that work on BrainGate research. (ABC7news.com)

Company Will Present Results of Clinical Trial of Rechargeable Sacral Neuromodulation in Overactive Bladder

April 18, 2017 - Axonics Modulation Technologies, Inc. will present initial results of its  prospective, multicenter clinical study of its rechargeable sacral neuromodulation system in 51 patients with overactive bladder at the International Neuromodulation Society 13th World Congress on May 30, 2017. (Yahoo Finance)

Analysis Tracks Infection Rates in Spinal Cord Stimulation Implants

April 14, 2017 - In an analysis of two U.S. payor databases, International Neuromodulation Society member David Provenzano, MD, found infection rates for spinal cord stimulation of 3.11% within one year of implant, which is approximately 1% higher than the rate for cardiac pacemaker implants. He called for identifying and evaluating common risk factors in a prospective manner. (Pain Medicine News)

Company Announces Brazilian Approval for Its Non-Invasive Brain Stimulation Products

April 13, 2017 - Soterix Medical said it has received regulatory approval in Brazil for its transcranial direct current stimulation products intended to address pain or depression. (P&T Community)

Company Announces FDA Approval for its Transcranial Magnetic Stimulation Device

April 12, 2017 - NeuroStar announced it has received FDA clearance for its most recent transcranial magnetic stimulation device, which provides treatment in 19 minutes, for use in major depressive disorder. (Mass Device)

Article Reports Tractography Aided Targeting in Deep Brain Stimulation for Depression

April 12, 2017 - Researchers prospectively planned surgical targeting of deep brain stimulation to the subcallosal cingulate in 11 patients with treatment-resistant depression, using diffusion tractography and 3-D modeling to guide individualized targeting. In Molecular Psychiatry, https://www.ncbi.nlm.nih.gov/pubmed/28397839 they report that after 12 months, nine of the patients were responders, with six in remission. (Medical Xpress)

FDA Nominee at Hearing: Devices May Aid Fight Against Opioid Crisis

April 6, 2017 - The nominee for FDA commissioner said at his confirmation hearing that a partial solution for the opioid abuse epidemic may be found in alternatives that include devices for pain control and drug-delivery devices. (Medtech Insight)

Experiments Explore Impact of Non-Invasive Brain Stimulation on Honesty

April 10, 2017 - Researchers found non-invasive brain stimulation increased honesty in experiments involving 300 university students. They report that transcranial direct current stimulation over the right dorsolateral prefrontal cortex made study subjects less likely to cheat for financial incentive on a die-rolling experiment, compared to controls. The study appeared in the Proceedings of the National Academy of Sciences.

Article Explores Genesis and Possibilities for Brain-Computer Interfaces

April 9, 2017 - Engineers at the University of Washington produced an overview about the state of brain-computer interfaces, and their inherent limitations and possibilities. They claim the brain may adjust to an interface just as people learn to drive a car or use a touchscreen. (The Conversation)

Researchers Publish Findings on Deep Brain Stimulation in Tourette Syndrome

April 7, 2017 - International Neuromodulation Society member Alon Mogilner, MD, PhD was quoted in an article about a study he published with colleagues in the Journal of Neurosurgery. In it, they report on 13 patients with refractory Tourette Syndrome who received deep brain stimulation over the past seven years, with at least six months of follow-up. On average, the patients achieved a 50% reduction in tic severity. The average position of the active contact was the the junction of the posterior ventralis oralis internus and the centromedian-parafascicular nuclei. (Washington Post)

Company Launches Neurostimulator in Australia

April 7, 2017 - Stimwave LLC has received regulatory approval from the Australian Therapeutic Goods Administration for its wireless spinal cord stimulation system. The company launched the product at the 12th annual meeting of the Neuromodulation Society of Australia and New Zealand. (Business Wire)

Article Announces the International Neuromodulation Society 13th World Congress

March 30, 2017 - An article that announces the International Neuromodulation Society's 13th World Congress, in Edinburgh May 27 - June 1, 2017, quotes International Neuromodulation Society President Timothy Deer, MD, about recent growth in the field and developments to be presented. (News-medical.net)

Tetraplegia Patient Demonstrates Restored Reaching and Grasping by Using a Functional Electrical Stimulation Neuroprosthesis and Brain-Computer Interface

March 28, 2017 - International Neuromodulation Society member Jonathan Miller, MD and co-authors report in The Lancet on a patient with tetraplegia who was recruited to the BrainGate2 clinical trial to use a brain-computer-interface with an implanted functional electrical stimulation system as a neuroprosthesis to voluntarily reach and grasp following spinal cord injury, (The Lancet)

Review Examines Studies of Non-invasive Brain Stimulation in Post-Stroke Therapy for Dysphagia

March 28, 2017 - Two researchers review studies about post-stroke rehabilitation for swallowing difficulty and conclude that clinical trials of motor recovery that includes use of non-invasive brain stimulation -- such as transcranial magnetic stimulation or transcranial direct current stimulation -- offer early signs of promise for treatment of dysphagia. (Dysphagia)

Entrepreneur Finances a Brain-Computer Interface Startup

March 28, 2017 - Technology entrepreneur Elon Musk has started a California firm called Neuralink to develop a brain-computer interface. He confirmed reports of the company he is funding and indicated more information will come out in a week. (Newsweek)

Neural Prosthesis Allows Paralyzed Man to Eat Using Robotic Arm

March 28, 2017 - A man paralyzed for eight years has demonstrated an ability to feed himself mashed potatoes by using his thoughts to move his arm, attached to a brain-computer interface, as part of the BrainGate research project. (Reuters)

Article Describes Development of a Custom Neural Prosthesis

March 27, 2017 - An article highlights the journey taken by one man who has received a custom neural prosthetic that allows him some use of his hand, bypassing the spinal cord injury that left him paralyzed seven years ago. (Daily Mail)

Company Reports Insurance Coverage for Peripheral Nerve Stimulation System

March 27, 2017 - Bioness, Inc. reported that its peripheral nerve stimulator received insurance coverage from Aetna, Inc. to treat chronic pain of peripheral nerve origin. (Yahoo Finance)

Device Company That is Focused on Chronic Low Back Pain Releases 2016 Annual Report

March 23, 2017 - Mainstay Medical International plc announced publication of its 2016 annual report. The company received CE mark approval for its neurostimulator for chronic low back pain in 2016 and initiated commercial sales in Germany earlier in 2017. In preparation for filing for pre-market approval in the U.S., the company has selected 27 clinical trial sites, where 18 are already enrolling patients. Enrollment completion is anticipated by the end of 2017 with data expected to be available in 2018. (Business Wire)

Study Suggests Spinal Cord Stimulation Curbs Opioid Use

March 22, 2017 - A study presented at the 2017 annual meeting of the North American Neuromodulation Society analyzed data for more than 5,400 patients between January 2010 and December 2014, finding that 70% of patients who received spinal cord stimulation reported declined or stabilized opioid use. (Pain Medicine News)

Physicians Report Two Cases of Peripheral Nerve Stimulation for Lower Back Pain

March 20, 2017 - International Neuromodulation Society members Leonardo Kapural, MD, PhD, John Chae, MD, Richard Rauck, MD, Michael Saulino, MD, Joseph Boggs, PhD and colleagues report in Pain Practice on two patients who received one month of peripheral nerve stimulation for chronic low back pain. They say the use of pain relievers dropped and the patient who had been taking opioids stopped, and the pain relief continued at least four months after therapy began. (Medical Xpress)

Journal Publishes a Long-Term Followup of Eight Patients with Depression who Received Deep Brain Stimulation

March 20, 2017 - Researchers in Germany report that seven of eight patients who received deep brain stimulation to the medial forebrain bundle for severe depression showed lasting improvements up to four years into treatment. The report appeared in the journal Brain Stimulation. (News-Medical.net)

Venture Capital Firm Invests in Early Stage Neuromodulation Company

March 20, 2017 - SetPoint Medical announced it has received an investment from the venture capital firm New Enterprise Associates (NEA), and NEA general partner Dr. Josh Makower has joined its board of directors. (Mass Device)

Updated Intrathecal Drug Delivery Guidelines are Featured

March 16, 2017 - International Neuromodulation Society member Peter Staats, MD, was interviewed for an article about the updated guidelines published in Neuromodulation: Technology at the Neural Interface by the Polyanalgesic Consensus Conference. The update ranks evidence and lists 32 consensus points. INS member Todd Sitzman, MD was quoted in the article as noting that the guidelines recommend lower medication concentrations and potentially safer daily dosages of many medications. Dr. Staats said he anticipates a resurgence of interest in intrathecal therapy for patients whose conditions are otherwise hard to manage. (Pain Medicine News)

Noninvasive Brain Stimulation Studied in Australia for Mild to Moderate Alzheimer's Disease

March 15, 2017 - An article profiles a patient with early stage Alzheimer's disease who participated in a small placebo-controlled clinical trial of repetitive transcranial magnetic stimulation for cognition, attention, memory and concentration. The treatment consisted of six weeks of treatments with theta-burst stimulation, which can target four sections of the brain in 12 minutes. She said her symptoms have not worsened and in some cases her memory has been helped. (Sydney Morning Herald)

Patient's Tourette Syndrome Symptoms Improve After Deep Brain Stimulation

March 14, 2017 - International Neuromodulation Society member Joohi Jimenez-Shahed, MD, an assistant professor of neurology at Baylor College of Medicine, was interviewed for a television segment about a patient with Tourette Syndrome whose symptoms improved after Dr. Jimenez-Shahed implanted a deep brain stimulation system. The patient is a high school girl's club lacrosse team coach who said she had been drained by trying to control her symptoms and thinking of taking a medical leave before the successful procedure 10 months ago. (Click2Houston)

Authors Report Six Months' Follow-Up of Pain Control Using Tibial Nerve Microstimulator

March 15, 2017 - International Neuromodulation Society members Pawel Sokal, PhD; Marek Harat, MD, PhD, and colleagues published a case series of six patients with peripheral neuropathic pain and complex regional pain syndrome who were treated with a wirelessly controlled microstimulator to provide tibial nerve stimulation. The authors report that pain relief was immediate and sustained for six months. They write that intermittent tibial nerve stimulation with such a device is safe and effective as well as minimally invasive. (Dove Press)

Publication Profiles Alzheimer's Patient Who Is Participating in a Deep Brain Stimulation Study

March 15, 2017 - A woman who received deep brain stimulation (DBS) a year ago in a small clinical trial of DBS for mild to moderate Alzheimer's disease is profiled in an ongoing series. (Vancouver Courier)

Updated Intrathecal Drug Delivery Guidelines are Featured

March 16, 2017 - International Neuromodulation Society member Peter Staats, MD, was interviewed for an article about the updated guidelines published in Neuromodulation: Technology at the Neural Interface by the Polyanalgesic Consensus Conference. The update ranks evidence and lists 32 consensus points. INS member Todd Sitzman, MD was quoted in the article as noting that the guidelines recommend lower medication concentrations and potentially safer daily dosages of many medications. Dr. Staats said he anticipates a resurgence of interest in intrathecal therapy for patients whose conditions are otherwise hard to manage. (Pain Medicine News)

Noninvasive Brain Stimulation Studied in Australia for Mild to Moderate Alzheimer's Disease

March 15, 2017 - An article profiles a patient with early stage Alzheimer's disease who participated in a small placebo-controlled clinical trial of repetitive transcranial magnetic stimulation for cognition, attention, memory and concentration. The treatment consisted of six weeks of treatments with theta-burst stimulation, which can target four sections of the brain in 12 minutes. She said her symptoms have not worsened and in some cases her memory has been helped. (Sydney Morning Herald)

Patient's Tourette Syndrome Symptoms Improve After Deep Brain Stimulation

March 14, 2017 - International Neuromodulation Society member Joohi Jimenez-Shahed, MD, an assistant professor of neurology at Baylor College of Medicine, was interviewed for a television segment about a patient with Tourette Syndrome whose symptoms improved after Dr. Jimenez-Shahed implanted a deep brain stimulation system. The patient is a high school girl's club lacrosse team coach who said she had been drained by trying to control her symptoms and thinking of taking a medical leave before the successful procedure 10 months ago. (Click2Houston)

Brain Stimulation to Improve Synchronization Aids Working Memory, Investigated as a Potential Therapy Tool

March 14, 2017 - In two experiments, with 10 or 20 healthy volunteers each, a research team determined that applying transcranial alternating current stimulation to induce frontoparietal synchronization enhanced performance on working memory tests, as tracked in brain-activity imaging via functional magnetic resonance stimulation. The researchers say they would like to later apply these methods to patients who have brain injury or epilepsy. The work was published in the journal eLife. (Medical Xpress)

Scientist Exploring Brain Stimulation for Stroke Rehabilitation Receives a Research Award

March 14, 2017 - A researcher studying transcranial brain stimulation as a potential treatment for stroke-induced aphasia has received an early career recognition from the American Academy of Neurology. (News-Medical.net)

Show Features Investigational Uses of Deep Brain Stimulation

March 13, 2017 - An online radio program about novel uses of deep brain stimulation (DBS) includes a research study by International Neuromodulation Society (INS) member Andre Machaco, MD, PhD, of DBS in stroke recovery, as well as research by INS member Jennifer Sweet, MD, into DBS for chronic pain or memory. (WKSU)

Television Show Profiles Sisters Who Received Deep Brain Stimulation for Obsessive Compulsive Disorder

March 12, 2017 - Twin sisters who received deep brain stimulation for obsessive compulsive disorder are featured on a segment of The Doctors. The young women's neurosurgeon, International Neuromodulation Society member David Vansickle, MD, explains the procedure in the program. (Yahoo News)

Patient From Noninvasive Brain Stimulation Study Describes Her Anorexia Symptoms

March 10, 2017 - An article profiles an anorexia patient who says she temporarily responded to a single dose of noninvasive electrical brain stimulation in a pilot trial for a graduate student's doctoral thesis in London. The stimulation targeted the dorsolateral prefrontal cortex, which is associated with impulsivity or self-control. (BBC News)

Group Calls For Comment on Proposed Workers' Compensation Revision

March 10, 2017 - The North American Neuromodulation Society, NANS, issued a news release asking for physician and patient comment on proposed revised rules by the California Division of Workers' Compensation that do not address coverage for neuromodulation for chronic pain. International Neuromodulation Society members Lawrence Poree, MD, PhD, and Nathan Miller, MD, have submitted published comments. (Business Wire)

Retinal Prosthesis Maker Raises About $20 Million

March 9, 2017 - Second Sight Medical closed a rights offering that raised approximately $20 million to support continued development and improvement of its retinal prosthesis. (Mass Device)

Bioelectronics Research Institute Enters Partnership to Address Cardiovascular Issues

March 9, 2017 - The Feinstein Institute for Medical Research entered a partnership with United Therapeutics Corp. to apply bioelectronics and cell-therapy technologies to cardiology and hypertension cases. (Innovate)

Neurostimulator Company Receives Expanded CE Mark for Disabling Migraine

March 9, 2017 - Autonomic Technologies, Inc. announced it received an expanded CE mark indication for its sphenopalatine ganglion stimulator for patients with highly disabling migraine. (PR Newswire)

Publisher Announces Travel Grant in Honor of International Women's Day

March 8, 2017 - Wiley has announced a Women in Research Travel Grant Competition. Women may apply, or be nominated, by March 31, 2017. A panel of editors-in-chief and society leaders from across disciplines will judge the applications. The winner will receive $2,000 to attend a conference in her research field. (Wiley)

Case Series: Patients Would Have Wanted Spinal Cord Stimulation as an Earlier Option

Feb. 27, 2017 - International Neuromodulation Society members Simon Thomson, MBBS; Dmitry Kruglov, MD, PhD; and Rui Duarte, PhD report data about 321 patients who had spinal cord stimulation trials at a single center from January 2008 until July 2015. Among their findings, they project a mean gain of 6.2 quality of life years. They add that 96.4% of the patients would have wanted SCS as an earlier treatment option. (Neuromodulation: Technology at the Neural Interface)

Deep Brain Stimulation Lowers Woman's Hypertension

Feb. 27, 2017 - International Neuromodulation Society member Nik Patel, MD has published a case in the journal Hypertension of a woman who is said to the the first to receive deep brain stimulation (DBS) to treat her high blood pressure. He had previously published a report of high blood pressure resolving in a patient who received DBS for neuropathic pain. (University of Bristol)

Pilot Study Investigates Vagus Nerve Stimulation in Stroke Recovery

Feb. 27, 2017 - At the International Stroke Conference, International Neuromodulation Society member Jesse Dawson, MD, presented results of a sham-controlled pilot trial of vagus nerve stimulation during rehabilitation for upper limb mobility following stroke. Treatment consisted of six weeks of stimulation. He said that 90 days after treatment ended, scores in the treatment group diverged from those of the sham group, and indicated significant improvement. (MedPage Today)

Survey Authors Conclude that Drug Delivery System Refilling Training Should be Standardized

Feb. 24, 2017 - International Neuromodulation Society member Gail McGlothen, DNP, RN has co-authored a U.S. survey of 65 healthcare professionals who refill intraspinal drug delivery systems. The article, in available online in Early View, concludes the high variability in methods calls for the need for standardized training to minimize risk of human error. (Neuromodulation: Technology at the Neural Interface)

Study Investigates Deep Brain Stimulation for Anorexia Nervosa

Feb. 24, 2017 - A study of 16 patients with anorexia nervosa who had deep brain stimulation to their subcallosal cingulate showed the intervention was safe and might help improve their symptoms, according to data published in The Lancet Psychiatry. (Medical Xpress)

Chronic Pain Patients Simulation Preferences Varied in Neurostimulation Clinical Trial

Feb. 23, 2017 - International Neuromodulation Society member Frank Huygen, MD, PhD and colleagues report in the European Journal of Pain that a multi-center, cross-over trial of five different types of stimulation in 29 patients with complex regional pain syndrome showed 48% preferred the standard frequency of stimulation and 54% preferred a non-standard one. (Neuro News)

Company Announces U.S. Patents for Its Sacral Neuromodulation System

Feb. 23, 2017 - Axionics Modulation Technologies, Inc. announced issuance of four U.S. patents related to the company's implantable sacral nerve stimulation technology. (Yahoo Finance)

Company Announces First European Implants of Its Neurostimulator for Peripheral Neuralgias

Feb. 22, 2017 - Bioness, Inc. announced a series of the first implantations of its percutaneous peripheral nerve stimulation system at medical centers in the Netherlands, Ireland, and Belgium. (Yahoo Finance)

Cognitive Training Improved Slightly with Transcranial Direct Current Stimulation in Home Study of Multiple Sclerosis Patients

Feb. 22, 2017 - A feasibility study of multiple sclerosis patients showed modest improvements from receiving transcranial direct current stimulation during 10 sessions of computer-based cognitive-training at home, while they were remotely monitored through video-conferencing. Compared to 20 patients who only received cognitive training, 25 patients who received simultaneous stimulation improved modestly in performance scores for complex attention tasks and reaction times. The results were published in Neuromodulation: Technology at the Neural Interface. (Mass Device)

Bioelectric Medicine Center Receives $25 Million Donation

Feb. 21, 2017 - The Feinstein Institute for Medical Research, which pursues research in bioelectric medicine, received A $25 million donation from philanthropists Leonard and Susan Feinstein, whose donation follows a $25 million donation in 2005 that led to the institute's renaming in their honor. (Innovate LI)

Review Examines Studies of Non-Invasive Stimulation in Stroke

Feb. 21, 2017 - A review about the safety of transcranial direct current stimulation (tDCS) in stroke rehabilitation says studies should describe exclusion criteria and induced adverse effects, in order to facilitate examination of factors that may induce side effects. Less than 12% of papers published between 1998 and 2015 reported adverse effects of tDCS in stroke patients. (Neuromodulation: Technology at the Neural Interface)

Column Highlights Research and Industry Developments Presented at Neuromodulation Meeting

February 2017 - A business column summarizes highlights from the 2017 annual meeting of the North American Neuromodulation Society, held in January. (Neurotech Reports)

Company Developing a Non-invasive Neurostimulator Raises Nearly $10 million

Feb. 16, 2017 - Helius Medical Technologies raised nearly $10 million in a public offering. The company plans to complete a clinical trial of its portable neurostimulator in treating mild to moderate traumatic brain injury. In addition, the company plans new clinical trials in multiple sclerosis and cognition, and to submit an FDA application. (Mass Device)

Startup Would Use Ultrasound to Non-Invasively Stimulate Vagus Nerve

Feb. 11, 2017 - A doctor and an engineer have begun investigating non-invasive stimulation of the vagus nerve through their startup company, Acuta Technologies. An article describes their interest in applying the technology to potentially address diabetes, or control appetite or inflammation. (Minneapolis Star Tribune)

Researchers Build Computer Model of Motor Circuits to Optimize Deep Brain Stimulation

Feb. 10, 2017 - In a research project at University College Dublin, a team is modeling the brain-to-muscle pathway as a way to develop smarter, closed-loop deep brain stimulation devices for Parkinson's disease. The article says there are some 2 million possible stimulation parameters, and the research is intended to help select optimal ones. (Silicon Republic)

Clinical Trial Will Examine Effect of Transcranial Magnetic Stimulation on Fear and Anxiety

Jan 24, 2017 - The National Institute of Mental Health is recruiting up to 126 healthy volunteers for a clinical trial to explore whether transcranial magnetic stimulation to the dorsolateral prefrontal cortex can reduce fear and anxiety. (Clinicaltrials.gov)

Company Developing Non-Invasive Stimulator Plans Public Offering

Feb. 10, 2017 - Helius Medical Technologies plans a public offering on the Toronto Stock Exchange that could bring in about Can$10.8 million. The company also announced publication of a pilot study of its non-invasive stimulator in patients with multiple sclerosis. (Seeking Alpha)

Marketing Clearance Received for Device to Improve Gait

Feb. 8, 2017 - A Bioness system that provides stimulation to assist with gait received FDA clearance. The system includes feedback and a learning algorithm to correct gait as a patient moves. (FDA News)

Brain-Computer Interface Research Attempts to Help Patients with Locked-In Syndrome Communicate

Feb. 7, 2017 - A researcher at the Wyss Center for Bio and Neuroengineering in Geneva is developing an EEG monitoring system for otherwise uncommunicative patients who have locked-in syndrome to respond to yes-or-no questions. (Extreme Tech)

Visual Prosthesis Research Explores Magnetic Stimulation

Feb. 7, 2017 - A magnetic micro-coil developer, PARC, announced unspecified funding from the National Institutes of Health through the U.S. BRAIN Initiative to develop a visual prosthetic in collaboration with the Massachusetts General Hospital, Harvard Medical School, and the University of Florida. The announcement said the funding is "a multi-year, multi-million dollar award". (Globe Newswire)

Article Highlights Importance of Data Analytics for Devices That Employ Neurosensing

Feb. 7, 2017 - An article says data analytics can help neurosensing applications to improve devices to address a number of conditions, such as helping store limb motion after spinal injury. (Healthcare IT)

Retinal Prosthesis Company Raises Funds

Feb. 6, 2017 - Second Sight Medical announced plans for a rights offering to raise additional funds to further develop its retinal prosthesis and expand the market to better-sighted patients who have retinitis pigmentosa. The company announced a decision by the German Institute for the Hospital Renumeration System last week that allows approved hospitals to negotiate for reimbursement by insurers for treatment of patients with advanced retitinitis pigmentosa. (Mass Device)

Company Seeks Regulatory Approval for Sacral Nerve Stimulation System

Feb. 1, 2017 - Nuvectra Corporation filed regulatory submissions with the FDA and CE mark authorities for its sacral nerve stimulation system to treat chronic urinary retention or overactive bladder symptoms. (Nasdaq)

Germany's First Patient Receives First Implant for Disabling Chronic Low Back Pain

Jan. 31, 2017 - Mainstay Medical International plc announced the first sale and implant of its neurostimulation system for disabling chronic low back pain in Germany. (Business Wire)

Cleveland Starts a Brain Health Initiative

Jan. 27, 2017 - The Cleveland Foundation is awarding $15. million grant to Case Western Reserve University to start a multi-institution Cleveland Brain Health Initiative. An article about the grant mentions a federal grant for stroke research by International Neuromodulation Society member Andre Machado, MD, PhD, chair of the Cleveland Clinic Neurological Institute.  (Cleveland Business)

Proof-of-Principle Study Explores Non-invasive Brain Stimulation for Bulimia Patients

Jan. 25, 2017 - A proof-of-principle clinical trial of transcranial direct current stimulation showed effects on bulimia symptoms the day after active stimulation, compared to sham, according to results in 39 patients. The results were reported in PLoS ONE. (Healio)

Study: Most Spinal Cord Stimulation Recipients Do Not Increase Opioid Use

Jan. 24, 2017 - An analysis of medical claims from 5,476 patients who received a spinal cord stimulator showed opioid use declined or stabilized in 70% of them, according to a study sponsored by Abbott and presented at the North American Neuromodulation Society annual meeting. (Pain News Network)

Physician Investigating Potential Benefits of Vagus Nerve Stimulation in Head Injury Patients

Jan. 24, 2017 - A physician has started a clinical trial for up to 30 patients who have had a traumatic brain injury or concussion, in order to investigate transcutaneous vagus nerve stimulation (VNS). Daily VNS sessions address cognitive or functional symptoms ascribed to "abnormal electrical currents in the brain," a news article says. (Minnesota Daily)

Company Prepares to Test Non-invasive Neuromodulation Device in Neuromotor Spasticity

Jan. 23, 2017 - PathMaker Neurosystems Inc. announced it will start a clinical trial in Paris of a non-invasive neuromodulation device to treat neuromotor spasticity. (Business Wire)

Peripheral Neurostimulation Studied in Post-Stroke Shoulder Pain

Jan. 21, 2017 - In a poster presentation at the annual meeting of the North American Neuromodulation Society, data on seven patients with post-stroke shoulder pain were presented. The data showed an average 70% reduction in the patients' pain, as rated in a visual analogue scale, following treatment with a peripheral neurostimulator. (National Pain Report)

Device Company Targeting Weight Loss Raises $19 Million

Jan. 19, 2017 - The company EnteroMedics Inc. announced it raised $19 million in an oversubscribed public offering. The company is commercializing a vagus nerve stimulation system for weight loss. (Mass Device)

Company Makes a Dorsal Root Ganglion Stimulator Available in Europe

Jan. 18, 2017 - St. Jude Medical, which is now part of Abbott, announced it is releasing a dorsal root ganglion stimulation system in Europe. (Medgadget)

New Prize in Neuromodulation Announced

January 2017 - A Science & PINS Prize for Neuromodulation was established in 2016 to honor contributions to neuromodulation research. Recipients will be honored annually for outstanding research as described in an essay based on research performed in the past three years. The award carries a prize of $25,000 and publication of the essay in Science Online, which is published by the nonprofit American Association for the Advancement of Science. Beijing PINS Medical Equipment Co. Ltd. develops nerve stimulation technologies. (Science)

Health Canada Approves a Rechargeable Sacral Neuromodulation System

Jan. 5, 2017 - Axonics Modulation Technologies, Inc. announced it received medical device approval  from Health Canada for its rechargeable sacral neuromodulation system to treat overactive bladder, fecal incontinence and urinary retention. (Yahoo Finance)

Vagus Nerve Stimulation Approach Blocks Unwanted Nerve Conduction

Jan. 5, 2017 - Biomedical engineers at Georgia Tech have designed a pair of vagus nerve stimulation electrodes that block stimulation in an afferent direction and force stimulation to only go in an efferent direction in order to lower inflammatory effects. The blocking electrode uses kilohertz frequency to block unwanted nerve conduction. (Medical Xpress)

First Patient Receives Implant in Clinical Trial of Deep Brain Stimulation for Motor Recovery After Stroke

Jan. 5, 2017 - International Neuromodulation Society member Andre Machado, MD, PhD, is interviewed for a news story about the first stroke patient to be implanted with a deep brain stimulation (DBS) system in his clinical trial of DBS in stroke recovery. The study will investigate if DBS and physical therapy combined help regain motor function. (WOIO)

Review: Non-invasive Neuromodulation is Useful for Migraine Management

January 2017 - A review of non-invasive stimulation in migraine treatment concludes, "Noninvasive neuromodulation is an exciting and useful method that is being increasingly recognised as a valid strategy for migraine management." (touch Neurology)

Small Study Shows Positive Results for Treating Depression in Elderly with Transcranial Magnetic Stimulation

Jan. 3, 2017 - A placebo-controlled study of 52 patients over the age of 60 who have treatment-resistant depression showed that deep transcranial magnetic stimulation led to half the patients achieving full remission, compared to only 16% of the sham-treated patients. (Nasdaq)

Journal Publishes New Consensus on Neuromodulation Therapy

Jan. 2, 2017 - The International Neuromodulation Society journal, Neuromodulation: Technology at the Neural Interface, has published updated guidelines for neurostimulation implants and intrathecal drug delivery. The six articles appear in Early View, and were authored by the Polyanalgesic Consensus Conference and the Neurostimulation Appropriateness Consensus Committee. These more than 60 international experts were convened by the INS Executive Board to provide guidance for improving safety and efficacy of these therapies that can help reduce opioid use. The authors reviewed publications that appeared in the scientific literature by 2014 to issue the updated guidance. (News-Medical.net)

Last Updated on Tuesday, June 20, 2017 04:04 PM