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Article Presents Vagus Nerve Stimulation as an Alternative to Pharmaceuticals

Dec. 5, 2016 - An article talks about existing and emerging uses of vagus nerve stimulation in a number of disorders, with comments by a number of academic researchers. (Wall Street Journal)

Data Over Seven Years Show Seizure Rate Decline with Responsive Neurostimulation

Dec. 5, 2016 - NeuroPace, Inc. presented seven years of clinical data on 185 epilepsy patients who have used the company's closed-loop responsive neurostimulation system. The company reported a median reduction in seizure frequency of 72% in the patients, whose condition is medically refractory. The results were presented at the American Epilepsy Society meeting in Houston. (Mass Device)

Article Presents Sacral Neuromodulation as an Alternative Treatment for Bladder Dysfunction

Dec. 4, 2016 - A publication in Singapore features the use of sacral nerve stimulation as a potential option not many patients know about for either urinary retention or overactive bladder. Patients who have one or the other of those conditions are interviewed in the article, as well as their physician. (Star 2.com)

Geneticist Studies Brain Stimulation in Preclinical Investigation of Childhood Neurological Disorder

Dec. 4, 2016 - A geneticist who received a $3 million Breakthrough Prize in the fifth year of the Silicon Valley science gala saw significant improvements in learning and memory through the use of deep brain stimulation in mouse models of the rare childhood disorder Rett syndrome. She said the findings may translate to other disorders. (Houston Chronicle)

Weekly Science Show Presents Neuromodulation for Paralysis

Dec. 3, 2016 - A weekly radio program presents research into spinal cord stimulation and brain-computer interfaces in paraplegia. (PRI)

Vagus Nerve Stimulation Shows Promise in Small Crohn's Disease Study

Dec. 1, 2016 - A small study of seven patients shows vagus nerve stimulation may address the symptoms of Crohn's disease. Over six months, five of the seven patients achieved endoscopic remission and four experienced clinical remission. (Gastroenterology & Endoscopy News)

Non-Invasive Brain Stimulation Apparently Reveals an Additional Memory Capacity

Dec. 1, 2016 - The journal Science published results of a memory study involving transcranial magnetic stimulation (TMS). In the study, subjects were asked to recall a cue and then given other memory tasks to hold in their short-term memory. With TMS stimulation, neural activity associated with the "forgotten" item spiked. An accompanying news article in the journal describes the observation of latent recall as a second level of working memory, saying that it might be based in synapses or other neural features. (Medical Xpress)

Neuromodulation Start-Up Pursues a Pulse Generator Without an Application-Specific Integrated Circuit

Dec. 1, 2016 - A medical technology start-up, Lone Star Neuromodulation, says it has created a programmable, wirelessly rechargeable, 17-electrode pulse generator primarily using off-the-shelf components and no custom integrated circuits. The company adds that the device "is subject to future testing, trials and regulatory approval." (PR Newswire)

Study Shows No Advantage to Changing Epilepsy Medication Following Vagus Nerve Stimulation Treatment

Nov. 28, 2016 - An 85-person comparative study from 2005 - 2014 showed there was no outcome improvement from changing anti-epileptic drugs after a patient started vagus nerve stimulation therapy. The authors suggest keeping the same medication may allow optimizing stimulation parameters. (Epilepsy Research UK)

Clinical Trials Explore Subperception Spinal Cord Stimulation

Nov. 23, 2016 - A pilot cross-over study published in Neuromodulation: Technology at the Neural Interface, compared three weeks of subperception spinal cord stimulation (SCS) with conventional SCS with parathesia at 10 kHz. An article suggests subperception SCS may be an effective alternative for some pain patients to find relief. The study is being followed by a subsequent multicenter, randomized, controlled, crossover, open-label study of 146 previously implanted patients that will document the efficacy of subperception SCS at up to 1.2 kHz. (Anesthesiology News)

French Research Center Raises Funds to Study Brain-Based Neural-Interface Devices

Nov. 22, 2016 - The French biomedical research center Clinatec has raised €10 million in the past 12 months in a matching-funds campaign with the Edmond J. Safra Foundation. The center is pursuing innovative treatments for cancer, neurodegenerative diseases and motor disorders. They include a brain-computer interface project for patients with quadriplegia; a near-infrared project to potentially provide neuroprotection and slow disease progression through use of an intracranial device delivering therapeutic light; and the Epicool project that aims to develop a cooling system implanted in the brain to block seizures. Also, the center is participating in the Equoloc project that studies potential brain dysfunctions in drug-resistant obsessive compulsive disorder, using imaging, including the center's MEG capability. (Business Wire)

Clinical Trial to Study the Use of Vagus Nerve Stimulation in Postpartum Hemorrhage

Nov. 22, 2016 - Partners were announced in a clinical trial of vagus nerve stimulation as a potential way to halt postpartum hemorrhage. The partners are the Global Good Fund, the Feinstein Institute, and Sanguistat, Inc., which licensed the technology from the Feinstein Institute. (PR Newswire)

Company to Expand and Extend Clinical Trial of Non-Invasive Device to Treat Symptoms of Neurological Disease or Trauma

Nov. 22, 2016 - Helius Medical Technologies amended its contract with the U.S. Army Medical Research and Material Command to extend it to the end of 2017 and include additional study sites for the clinical trial of the portable neuromodulation stimulator to treat neurological symptoms caused by disease or trauma. (FDA News)

Researchers Plan a Multi-Center Clinical Trial After Showing a Sustained Benefit from Deep Brain Stimulation in Early Parkinson's Disease

Nov. 17, 2016 - A 30-patient randomized study of patients with early Parkinson's disease found that individuals who had deep brain stimulation had better motor scores five years later, compared to those who only had medical treatment. The pilot study was presented in October at the annual meeting of the American Neurological Association. The researchers at Vanderbilt University said they are now pursuing funding for an FDA-approved Phase 3 clinical trial of 280 patients at 18 centers. (Neurology Today)

Study Investigates Non-Invasive Peripheral Nerve Stimulation in Veterans with Post-Traumatic Stress Disorder

Nov. 17, 2016 - Compared to sham stimulation, combat veterans with post-traumatic stress disorder showed improvements in autonomic nervous system electrophysiological measures and in the emotionally-modulated startle response following non-invasive peripheral nerve stimulation, researchers reported in an abstract at the Society for Neuroscience Annual Meeting. (Psychiatry Advisor)

Transcranial Direct Current Stimulation Investigated in Depression

Nov. 16, 2016 - A researcher described her small pilot study of transcranial direct current stimulation (tDCS) on depressed pregnant women who do not want to take antidepressants. At the University of Kansas, another researcher received $70,000 in funding to use brain imaging to compare the effects of tDCS on 40 subjects, half of whom have depression. (PBS)

Researcher Targets Brain Structures with Overlapping Non-Invasive Stimulation

Nov. 15, 2016 - A researcher presented early studies in healthy subjects to use non-invasive brain stimulation to target the hippocampi as a potential treatment for Alzheimer's disease. Imaging showed increased localized brain activity as a result of the stimulation. He also plans to target areas involved in depression and addiction. The stimulation involves using overlapping high-frequency stimulation that only exerts a physiological effect where the fields overlap and result in a lower-frequency stimulation. (New Scientist)

Researchers Seek an "Ideal Bioelectronic Interface"

Nov. 15, 2016 - An article described research into printing microelectronics on hydrogels as potential future brain-machine interfaces. (SPIE)

Retrospective Review Analyzes Post-Surgical Complications of Deep Brain Stimulation

Nov. 5, 2016 - A review of 650 cases in which Parkinson's disease patients underwent deep brain stimulation provides data that "can be used as an adjunct for short-term risk stratification" when patients are considered for the therapy, the authors state. (World Neurosurgery)

Researchers Explore a Hydrogel for Optogenetics Applications

Nov. 15, 2016 - Researchers at MIT and Harvard Medical School are working on a biocompatible, stretchable material with potential applications in optogenetics, according to an MIT news release. (Medica Magazine)

Spinal Cord Stimulation System Receives Approval for Full-Body, Conditional, MRI Scans

Nov. 14, 2016 - St. Jude Medical has received FDA approval for conditional full-body MRI using its spinal cord stimulation system that was approved in November 2015. (Fierce Biotech)

Company Demonstrates a Robotic Transcranial Magnetic Stimulation System

Nov. 14, 2016 - During the Medica 2016 trade show currently taking place in Germany, the ICube spinoff Axilum Robotics presented a robotic transcranial magnetic stimulation system intended for precision and repeatability in treatments of patients with chronic pain and other conditions. (Medical Plastics News)

Investigators Say Spinal Cord Stimulation Improved Gait in Patients with Advanced Parkinson's Disease

Nov. 10, 2016 - An article says that four patients who had advanced Parkinson's disease and had had deep brain stimulation experienced improved gait after spinal cord stimulation. (Movement Disorders)

Reviewers Examine Possible Mechanisms in Deep Brain Stimulation for Obsessive Compulsive Disorder

Nov. 9, 2016 - In a review, authors interested in the role of deep brain stimulation to the subthalamic nucleus for obsessive compulsive disorder say this target "has a coordinating role in decision-making and action-selection mechanisms" and they believe the treatment helps to normalize the disturbed circuit activity seen in the condition. (European Neuropsychopharmacology)

Column Describes Reimbursement Issues in Pre-Approved, Off-Label Deep Brain Stimulation

Nov. 7, 2016 - A viewpoint article raises the issue of third-party payers, including federal insurance providers, not reimbursing pre-approved off-label use of deep brain stimulation for severe, medication-refractory neurological and psychiatric disorders such as Tourette syndrome and obsessive compulsive disorder. (JAMA Neurology)

Brain-Machine Interface Study: Sensorimotor Plasticity Connected to Phantom Limb Pain

Nov. 4, 2016 - International Neuromodulation Society members Koichi Hosomi, MD, PhD; Haruhiko Kishima, MD, PhD; and Youchi Saitoh, MD, PhD and colleagues co-authored an article in Nature Communications, "Induced sensorimotor brain plasticity controls pain in phantom limb patients" The article describes phantom limb pain observed when study subjects used a brain-machine interface to move a robotic hand. When the interface used sensorimotor signals representing the missing limb, the pain increased -- perhaps due to the lack of sensory feedback, the authors commented. (Clinical Pain Advisor)

Patient with Locked-In Syndrome Uses Brain-Machine Interface to Type

Nov. 12, 2016 - Researchers in Utrecht reported in the New England Journal of Medicine that they have demonstrated a brain-computer interface that allowed an ALS patient who has no voluntary movement except for her eyes to use cortical brain signals to slowly spell words using typing software. The interface responds to her imagining she is moving her hand. A member of the team said the implant provides a way to communicate immediate needs. He added that she had been avoiding going outdoors because the eye-tracker she uses to communicate must be re-calibrated in different light conditions. (The Seattle Times)

U.S. Army Veterans to Participate in a Clinical Trial of Non-Invasive Vagus Nerve Stimulation for Pain and Related Symptoms

Nov. 10, 2016 - Researchers in New York plan to undertake a randomized clinical trial of 40 veterans of the 1990 - 1991 Gulf War who have widespread pain and migraines. The study, funded by a $703,200 medical research grant from the U.S. Army, will investigate the use of non-invasive vagus nerve stimulation to treat their symptoms. (Newswise)

Article Covers High-Frequency Spinal Cord Stimulation Clinical Trial Results

Nov. 9, 2016 - International Neuromodulation Society members Leonardo Kapural, MD, PhD, and Kiran Patel, MD, were quoted in an article about a recently published study of high-frequency spinal cord stimulation. (UPI)

Preclinical Study Demonstrates a Neuroprosthetic that Overcomes a Partial Spinal Lesion

Nov. 9, 2016 - An international research team reported in a letter to Nature that they had demonstrated two monkeys the capability of restoring movement to a lower limb through dual electrode interfaces at the brain's motor cortex and the lower spinal cord. With the neuroprosthetic implant, the research subjects regained the ability to walk following a spinal lesion that paralyzed one leg. (Seeker)

Newly Public Device Company Reports Quarterly Earnings

Nov. 9, 2016 - Nuvectra Corporation announced a 196.3% increase in revenue in the third quarter of 2016, compared to the third quarter of 2015, related to a deep brain stimulation development agreement with Aleva Neurotherapeutics and commercial launch of Nuvectra's spinal cord stimulation system. The revenue of $3.8 million for the third quarter of 2016 was offset by operating expenses of $11.1 million. The company said the costs reflect its investment in a sales and marketing team and increased headcount after becoming a publicly traded company. (Globe Newswire)

Authors Review Deep Brain Stimulation in Psychiatric Conditions

Nov. 8, 2016 - A journal article says relative safety and efficacy of deep brain stimulation has become more widely accepted, adding that investigations into its use in psychiatric disorders "suggest moderate benefit in many cases and remain encouraging." (Psychiatric Annals)

Device-Maker Raises Equity Funds

Nov. 8, 2016 - An SEC filing shows that Inspire Medical Systems, which developed and produces a sleep-apnea implant, raised $12.5 million in equity financing. (Mass Device)

Non-invasive Brain Stimulation Improved Study Participants' Ability to Multi-task

Nov.8, 2016 - A controlled study of 20 Air Force personnel found that transcranial direct current stimulation increased working memory when they undertook a test that required them to multitask. The authors think the stimulation may help with attention and vigilance. (International Business Times)

Company's MRI-Conditional Leads Enter Use in Canada

Nov. 8, 2016 - Medtronic Canada announced the first patients had been implanted with its spinal cord stimulation leads that are licensed for full-body MRIs under specified conditions. The announcement noted the leads have been approved by the regulatory body Health Canada. (Newswire)

Scotland Centre for Deep Brain Stimulation is Delayed

Nov. 8, 2016 - The BBC reports that a specialty center to provide deep brain stimulation for movement disorder patients in the north and east of Scotland is delayed and not expected to open until the spring after final equipment and staffing arrangements are made. (BBC News)

First U.K. Implant Announced in a Clinical Trial of a Retinal Prosthesis

Nov. 7, 2016 - The first retinitis pigmentosa patient in the U.K. received an implanted retinal prosthesis in a clinical trial by the device company Pixium Vision. (Mass Device)

Article Profiles Participant in a Clinical Trial of Deep Brain Stimulation for Alzheimer's Disease

Nov. 4, 2016 - A Canadian woman who is participating in a clinical trial of deep brain stimulation in Alzheimer's disease describes her experience in an article that mentions the search for 97 more participants to enter the third phase of the clinical trial. Results of the second phase, published in September, showed a trend toward a benefit in patients above age 65. The clinical trial investigates stimulation of the fornix as a potential intervention for mild Alzheimer's disease. (CBS News)

Study Examines Repetitive Transcranial Magnetic Stimulation in Phantom Limb Pain

Nov. 3, 2016 - A randomized controlled clinical study of 54 patients with phantom limb pain following traumatic limb loss from land mine explosions indicated that repetitive transcranial magnetic stimulation produced better results than sham over the two-week treatment period, but the effects faded by 30 days post-treatment. The study author commented that in other pain disorders, periodic maintenance stimulation treatments have been safe and effective for sustaining benefit. (Pain Medicine News)

Company Announces Medicare Payment Decisions for Its Retinal Prosthesis

Nov. 2, 2016 - Second Sight Medical announced that in 2017 its retinal prosthesis will have a new Medicare implantation payment rate and billing codes for programming or reprogramming. (Mass Device)

Patient Organization to Present Talk on Deep Brain Stimulation

Nov. 2, 2016 - International Neuromodulation Society member David VanSickle, MD, discussed changing guidelines of when to consider deep brain stimulation for Parkinson's disease in an article announcing an upcoming presentation organized by the Parkinson's Association of the Rockies. (Steamboat Today)

Report Sees Growing Role for Deep Brain Stimulation

Nov. 2, 2016 - A market report predicts that by the end of the year 2021, deep brain stimulation will represent almost 20% of the market share for neurostimulation devices. (Business Wire)

Laboratory Device May Enable Neurostimulation Implants to Also Administer Chemical Agents

Nov. 2, 2016 - A research team has demonstrated the capability of delivering neurotransmitters at nearly the same rate as neurons. An article says this technology could be coupled with deep brain stimulation to provide chemical treatment in addition to electrical stimulation in conditions such as epilepsy. (IEEE Spectrum)

To see select neuromodulation news by category, as well as news about the INS in particular, please visit the Newsroom. To see archived news briefs dating back to January 2011, visit the News Archive.

How Has Neuromodulation Been Developed and Used?

Conventional medicine has typically had four modes of treating diseases or disorders: counseling or “talk therapy”; physical therapy involving manipulation and strengthening of muscles and range of motion; pharmaceuticals that act on a chemical level; and altering or augmenting tissue through surgery, injections, or filtering methods like dialysis. The growing field of neuromodulation is a new class of therapies that involves directly treating the nervous system itself, often through small implanted devices that target a specific area, to rebalance the activity of neural circuits and manage symptoms.

Progress has been spurred by advances in our understanding of the nervous system, as well as new technologies and clinical experience, enabling treatments to modify nerve cell activity in brain, spinal cord and periphery to restore function, minimize pain, and treat disease symptoms. Developed over the last 45 years, neuromodulation has grown rapidly into a family of therapies that applies stimulation or agents directly to the nervous system, often using small implanted medical devices that are powered in a similar fashion to a cardiac pacemaker. By delivering electrical or chemical stimulation, neuromodulation has increasingly been used to treat motor disorders such as Parkinson’s disease, refractory chronic pain ranging from neuropathy to cancer related pain to severe headaches, spasticity, epilepsy, and incontinence. It is also under study for conditions ranging from gastroparesis to medically refractory depression. Providers of such therapies include neurosurgeons, pain physician specialists and rehabilitation physicians. They may often work with other specialists such as neurologists, psychiatrists, psychologists, gastrointestinal or colorectal specialists, urologists, primary care physicians, and physical therapists to achieve best outcomes.

Learn More . . .

Medical Professionals can learn about various considerations concerning neuromodulation and clinic contacts. Once your preliminary questions have been answered, please use the Contact Us facility to find out more and to discuss specific objectives. Others may simply wish to join the INS and one of its related chapter societies, please use Membership Application.

Clinical trials that involve a wide range of emerging neuromodulation approaches are listed on our Resources and Research pages. Neuromodulator trials address symptom control through nerve stimulation in such condition categories as:

If you are not a medical professional
and you are searching for information about neuromodulation and how these types of treatment could benefit a specific condition such as treatment-resistant headache or other chronic pain syndromes, you may find the sections titled Therapies, About Neuromodulation or FAQs particularly helpful.

The International Neuromodulation Society (INS) is a non-profit group of clinicians, scientists and engineers dedicated to the scientific development and awareness of neuromodulation - the alteration of nerve activity through the delivery of electrical stimulation or chemical agents to targeted sites of the body. Founded in 1989 and based in San Francisco, CA, the INS educates and promotes the field through meetings, its peer-reviewed journal Neuromodulation: Technology at the Neural Interface, explanatory content, and chapter websites.

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Neuromodulation: Technology at the Neural Interface
contains articles of the highest scientific caliber. The journal's sole purpose is to advance the basic and clinical science of the field of neuromodulation. In eight issues a year, it publishes scientific works, scientific reviews, and abstracts of papers accepted for review at national and international congresses.

Neuromodulation is indexed in Index Medicus, MEDLINE and Pubmed!

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Last Updated on Tuesday, December 06, 2016 02:51 PM
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