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Heart Failure, Hypertension Therapy Granted MRI-Conditional Status in Europe

Dec. 16, 2014 - CVRx Barostim neo is now cleared for MRI use in Europe under certain conditions, according to a company announcement. This second-generation carotid artery pulse stimulator is being developed as a therapy for some types of heart failure and drug resistant hypertension. (MedGadget)

Company Prepares for Shareholder Vote on Merger

Dec. 16, 2014 - Medtronic, Inc. announced it is ready for a shareholder vote Jan. 6, 2015, on the proposed merger with Covidien, now that the way has been cleared by anti-trust regulators from the U.S., European Union, China, South Korea and Canada. (Mass Device)

Company Says Patent Issued on Treatment for Balance Problems

Dec. 16, 2014 - Helius Medical Technologies, Inc. said it has received a U.S. patent "generally directed to a non-invasive neuromodulation therapy that includes stimulating the cranial nerves found in the mouth while the patient is engaged simultaneously in physical movement." The company's Portable Neuromodulation Stimulator (PoNS™) device induces neuromodulation by stimulating the cranial nerves found in the tongue, and is being studied for the treatment of balance disorder symptoms caused by traumatic brain injury and multiple sclerosis. (Business Wire)

North American Neuromodulation Society Issues Lifetime Achievement Award

Dec. 16, 2014 - The North American Neuromodulation Society presented a Lifetime Achievement award to Prof. Alim Louis Benabid, board chairman of Clinatec - The Edmond J. Safra Biomedical Research Center for his work on developing deep brain stimulation for Parkinson's disease. (News-Medical.net)

U.S. Agency Seeks Capabilities to Stimulate Peripheral Nervous System to Treat Disease

Dec. 15, 2014 - A news release says, "DARPA’s Electrical Prescriptions (ElectRx) program is seeking innovative research proposals to help transform neuromodulation therapies from last resort to first choice for a wide range of diseases." The agency has issued a notice of capabilities sought that "would leverage advanced sensing and stimulating technologies to target specific peripheral neural circuits that control organ functions." Both inflammatory disease and mental health disorders are being targeted. (Medical Design Technology)

 

Dorsal Root Ganglion Studies Presented

Dec. 15, 2014 - Twenty peer-reviewed abstracts were presented at the North American Neuromodulation Society meeting about dorsal root ganglion stimulation using Spinal Modulation's Axium neurostimulator system for chronic pain. The studies in Australia and Europe included chronic post-surgical pain, upper limb neuropathy, and visceral pain. (Business Wire)

Post-Traumatic Stress Disorder Clinical Trial to Start

Dec. 15, 2014 - Israel's Brainsway said it will carry out a clinical trial of deep transcranial magnetic stimulation with FDA clearance in 166 patients who have post-traumatic stress disorder. (Mass Device)

Brain Stimulation Said to Boost Performance on Anti-Anxiety Training

Dec. 15, 2014 - An article in Biological Psychiatry says transcranial direct current stimulation to a region of the frontal cortex helped subjects perform better at a task designed to retrain unhelpful patterns of attention that are known to maintain high levels of anxiety, in which participants endeavor to direct their attention away from "unhelpful information". (Health Canal)

Article Highlights Transcranial Magnetic Stimulation Use in Treatment-Resistant Depression

Dec. 15, 2014 - A news feature on transcranial magnetic stimulation for depression says up to one-third of patients can achieve remission, and about 50 - 60% of patients show some response. (U.S. News & World Report)

Neurosurgery Resident Presents Neuromodulation for Future Health Practitioners

Dec. 12, 2014 - International Neuromodulation Society member Shannon Hann, MD, has authored an article with INS President Simon Thomson, MBBS on a website devoted to future healthcare professionals that introduces neuromodulation as a modality they may see more of in their future. (Student Doctor Network)

Anti-Pain Device Clinical Trial Will Enroll Patients Who Have Axial Low Back Pain Without Prior Back Surgery

Dec. 12, 2014 - Stimwave Technologies Inc. announced a randomized, double-blind, placebo-controlled study, Tsunami, to evaluate its miniature, wireless anti-pain neuromodulation device in 45 patients who have chronic, non-specific-origin lower back pain. The study will begin enrollment in 2015 in the U.K., Netherlands, Switzerland and Belgium. In addition to pain reduction, secondary endpoints are quality of life, patients' global impression of change and reduction in opioid use. (Mass Device)

Company Presents Several Studies of Spinal Cord Stimulation at North American Neuromodulation Society Meeting

Dec. 12, 2014 - Retrospective data presented at the 18th North American Neuromodulation Society meeting show that stimulation targeting enabled by Boston Scientific Corporation's 32-contact Precision Spectra spinal cord stimulator system and anatomy-driven Illumina 3D™ software contributed to pain reduction that averaged more than 50% in 213 patients at 12 months. Other presentations included describing a 10-kHz spinal cord stimulation trial, ACCELERATE, and a clinical trial evaluating sub-perception multiple independent current control, WHISPER. (PR Newswire)

Company Presents Advances in Chronic Pain Therapy

Dec. 11, 2014 - Medtronic, Inc. planned to exhibit a variety of pain-control products during the North American Neuromodulation Society annual meeting, and to highlight two in particular; the high-density programming option AdaptiveStim®HD and the SureScan® spinal cord stimulation system that provides access to MRI imaging of the body under specific conditions. (Nasdaq)

Scoliosis Patient Reported to Benefit From Spinal Cord Stimulation to Limit Chronic Pain

December 2014 - International Neuromodulation Society member Sanjay Sastry, MD, and colleagues in Florida report a case of a man with spinal curvature and chronic pain from spine surgery who successfully received a spinal cord stimulator implant to manage his chronic pain symptoms. (Pain Medicine News)

Business Column Describes Bioelectronic Therapies

Dec. 10, 2014 - In a healthcare innovation column the Financial Times mentions the GlaxoSmithKline initiative with SetPoint Medical to modulate the vagus nerve to treat inflammatory disease, and electroCore's research into vagus nerve stimulation therapies. The column also mentions FDA approval of the Inspire Medical Systems "bioelectronic" system to treat obstructive sleep apnea, and EnteroMedic's FDA-approved system to control food intake through vagus nerve stimulation. The column cites revival of a newborn by cardiac electrostimulation in 1928 as the start of the modern era of bioelectronic medicine. (Financial Times)

Membrane Might Add Sense of Touch to Prostheses

Dec. 10, 2014 - Researchers from Seoul National University report in Nature Communications development of stretchable ​silicon nanoribbon electronics for skin prosthesis that might transfer signals to nerves via an ultrathin multi-electrode array. (Business Insider Australia)

Optogenetics Research Suggests New Intervention Target in Temporal Lobe Epilepsy

December/January 2014 - Data presented at the American Epilepsy Society’s annual meeting in Seattle indicate optogenetics may be a promising future therapy; researchers at the University of California in Irvine showed that in a mouse model of temporal lobe epilepsy, activating cells in the lateral cerebellar cortex or vermis with optogenetic lasers shortened seizures and in the case of the vermis, also prolonged seizure-free periods. The results indicate the cerebellum could be a good target for intervention, and reveal a strong influence between brain structures that are not typically thought to interact. (Neurology Now)

Political Leader Speaks Out in Favor of Bringing Deep Brain Stimulation to Ireland

Dec. 9, 2014 - After a session of the Oireachtas Health Committee, Dan Neville, the chair of the Fine Gael Party and assembly delegate to the Irish parliament, said that bringing a deep brain stimulation service to Ireland rather than flying patients to the UK for treatment will be kept under continuous review within the context of competing priorities. (Fine Gael)

Parents of Middle-Schooler with Dystonia Contemplate Future Deep Brain Stimulation Therapy

Dec. 6, 2014 - Relatives of a 12-year-old boy with dystonia describe their experience and how they are considering deep brain stimulation in the future, which is said to improve about 80% of the cases of his type of dystonia, DYTi. (American Epilepsy Society)

Physicians Update Recommendations on Deep Brain Stimulation in Severe Tourette Syndrome

December 2014 - International Neuromodulation Society members Andre Machado, MD, PhD; Alon Mogilner, MD, PhD; Joseph Neimat, MD; Barbara Changizi, MD; Verle Visser-Vandewalle, MD; Michael Pourfar, MD; J. G. Zhang, MD and colleagues have published updated recommendations regarding deep brain stimulation for Tourette syndrome, noting that the therapy can be a promising approach for a subset of medication refractory and severely affected patients. (Movement Disorders)

Ostomy Patient Publicizes Her Pain Relief from a Spinal Cord Stimulator

Dec. 8, 2014 - A woman who suffered neuropathic pain after a portion of her intestinal tract was removed says spinal cord stimulation relives 80-85% of her pain. (Great Falls Tribune)

Company's Pain Portfolio to be Presented

Dec. 8, 2014 - St. Jude Medical, Inc. will present data from 16 research abstracts about its product portfolio to provide spinal cord stimulation for chronic pain during the North American Neuromodulation Society annual meeting Dec. 11 - 14, 2014 in Las Vegas, NV. (Business Wire)

Authors Examine New Directions of Deep Brain Stimulation

December 2014 - International Medical Society member Jonathan Miller, MD, has co-authored an article about new directions in deep brain stimulation that says, "The intersection of advances in neuromodulation, neurophysiology, neuroimaging, and functional neuroanatomy has created an environment rife with new therapeutic possibilities." (PubMed)

Federal Agency, Patient Groups Team Challenge Developers to Devise Seizure Data Algorithms

Dec. 6, 2014 - The National Institute of Neurological Disorders and Stroke, American Epilepsy Society and the Epilepsy Foundation sponsored an online competition that drew 504 entrants who used recordings of seizures in both canines and people to try to develop algorithms to detect and predict the events. The winning team forecast abnormal brain activity with 82% accuracy. An article says the sponsors hope that one day the predictive algorithms will help to reduce seizures through being "married with the computing power of handheld devices and be used by epileptics." (Washington Post)

Company Starts Proof-of-Concept Anti-inflammatory Clinical Trial of Vagus Nerve Stimulation in Crohn's Disease

Dec. 4, 2014 - In conjunction with the  Crohn’s & Colitis Foundation’s annual conference in Orlando, SetPoint Medical announced the start of a clinical trial of a bioelectronic medicine therapy for Crohn's Disease. The proof-of-concept study will include patients at five centers in Europe whose condition did not respond to treatment with a tumor necrosis factor antagonist drug. SetPoint's implanted device will be used to stimulate the vagus nerve to produce a systemic anti-inflammatory effect. (Business Wire)

Merger Plans Receive Antitrust Clearance from China and Korea

Dec. 4, 2014 - The Chinese Ministry of Commerce and the South Korean Fair Trade Commission have accepted plans for Medtronic, Inc. to merge with Covidien Plc, according to Medtronic. With all antitrust clearances in hand, the companies now need sanction by the High Court of Ireland and shareholder approval. Covidien is based in Ireland and the combined company would have its tax domicile in Ireland, with operational headquarters in the U.S. (Mass Device)

Scientists Demonstrate Potential of Wireless Film to Serve as Retinal Implant

Dec. 3, 2014 - A collaboration between researchers in Israel and the U.K. has developed a light-sensitive film that could some day form the basis of a prosthetic retina. The film combines semiconductor nanorods and carbon nanotubes and has shown a response in neural tissue in preliminary studies. (The Hebrew University of Jerusalem)

Irish Health Officials Hear Benefits of Deep Brain Stimulation

Dec. 3, 2014 - The Ireland Committee on Health and Children planned to continue discussing deep brain stimulation benefits and how it can improve the lives of people with Parkinson's disease, a discussion started at its meeting last month with providers and patient representatives. (Houses of the Oireachtas)

Refractory Angina Pectoris Patients Showed Improved Perfusion After Spinal Cord Stimulation

Dec. 2, 2014 - International Neuromodulation Society members Pirkka Rautakorpi, MD and Markku Taittonen, MD, PhD, and colleagues from Turku University Hospital in Finland have published a prospective case series that indicated that three weeks of continuous spinal cord stimulation in 18 patients with refractory angina pectoris was able to alleviate myocardial perfusion abnormalities from coronary artery disease. (European Heart Journal Cardiovascular Imaging)

Pakistan Patient Expresses Appreciation for Deep Brain Stimulation Surgery

Dec. 4, 2014 - A patient who received a deep brain stimulation implant for an unspecified indication in Lahore last month spoke with the news media and expressed appreciation for government support for the surgery which he could not afford to have overseas. He said that the operation bestowed him a new life and he will not have to spend his life dependent on others. (Pakistan Observer)

First Auditory Brainstem Implants Performed on Preschoolers in India with Government Support

Dec. 3, 2014 - Two children in India had auditory brainstem implants with government support, which is usually available for the more-common cochlear implant procedure. The procedures, performed in November, were also written up in The Hindu. The surgery was presented as the first time it was done in Asia with government funding; a representative of a research foundation said the procedure has only been done in Korea, France, Germany, the U.S., Italy, Turkey and India. (The New Indian Express)

Article Highlights Military Research into Performance-Enhancing Technology

Dec. 3, 2014 - The U.S. military is researching brain-stimulation techniques for cognitive enhancement to improve focus or memory, as well as devices such as exoskeletons to permit carrying more weight. (Vox)

Company Reports Record Revenues, Plans to Present at International Neuromodulation Society Chapter Annual Scientific Meeting

Dec. 2, 2014 - Nevro Corp. booked its biggest revenue gain in the quarter ended Sept. 30, 2014, the company announced, with $8.7 million in revenues marking a 40% increase over the same period the year before. The company added that results of its randomized controlled clinical trial, SENZA-RCT, will be presented Dec. 12 in Las Vegas at the annual meeting of the North American Neuromodulation Society. The Senza spinal cord stimulation system is marketed outside the U.S. Combined with that revenue, the company also raised approximately $131 million in an initial public offering and secured a $50 million credit facility. (BusinessWire)

Feature Profiles Dystonia Patient Who Received Deep Brain Stimulation

Dec. 2, 2014 - A health care worker in Idaho who has dystonia described how her symptoms lessened after she had a deep brain stimulation implant. (Deseret News)

U.S. Patient Enrollment Complete for Study of Dorsal Root Ganglion Stimulation for Chronic Pain

Dec. 2, 2014 - Enrollment has been completed for the randomized, controlled pivotal trial of the Axium Neurostimulator System, Spinal Modulation announced. The study co-lead, International Neuromodulation Society member Timothy Deer, MD, commented that results from European studies have been promising. The U.S. study, ACCURATE, has 152 patients at 22 centers who either have pain from nerve injuries (peripheral causalgia) or complex regional pain syndrome. The Axium targets the dorsal root ganglion, unlike traditional spinal cord stimulators. The ACCURATE study is considered the largest study of patients who suffer from peripheral causalgia or complex regional pain syndrome. The design of the ACCURATE study will be presented at the annual meeting of the North American Neuromodulation Society, as well as clinical outcomes from Europe and Australia, where the system is commercially available. (CNN Money)

FDA Approves Injectable Wireless Spinal Cord Stimulator

Dec. 2, 2014 - Stimwave Technologies Incorporated announced it has received FDA clearance to begin marketing its wireless microtechnology device, the Stimwave Freedom Spinal Cord Stimulation (SCS) System (TM), which is expected to be available in January 2015. Bearing electrode contacts and a microchip, the device is 2-11cm in size, and can be implanted through a standard needle. The permanent implant is designed to allow a patient to have a whole-body MRI of up to 3 Tesla, greater than is currently available. David Kloth, MD, president of the International Neuromodulation Society's North American chapter, hailed the arrival of this new option for chronic pain patients. (Yahoo News)

Company Completes $17 Billion Debt Offering

Dec. 1, 2014 - Medtronic, Inc. raised $17 billion in a corporate-debt bond sale to finance its acquisition of Covidien Plc. The deal was the largest corporate debt offering in more than a year. The investment-grade bonds were given a provisional rating of A3 by Moody's Investors, and had maturities of three to 30 years, with a 10-year bond offering a total yield of 3.613. The offering reportedly attracted $45 billion in orders. (Wall Street Journal)

International Neuromodulation Society Member Comments on Value of Collaborative Database

Dec. 1, 2014 - The free-to-use, searchable, collaborative database of primary neurostimulation research data, WIKISTIM, announced in its monthly newsletter that it received two unexpected donations last month and will present two posters at the December annual meeting of the North American Neuromodulation Society. In addition to previous corporate donations and a new donation of $5,000 from Greatbatch in recognition of the value of the site to its employees, an individual donation came from International Neuromodulation Society member B. Todd Stizman, MD, PhD, who was quoted as remarking that the benefit of the resource "should be obvious to all [spinal cord stimulation] implanters, academic and private practice," adding that more should know about the initiative. Section editors include INS members Tracy Cameron, PhD; Elliot Krames, MD; Bengt Linderoth, MD, PhD; Robert Foreman, MD, PhD; Richard North, MD; and Konstantin Slavin. MD. (A sacral nerve stimulation section editor is to be determined.) (WIKISTIM)

To see select neuromodulation news by category, as well as news about the INS in particular, please visit the Newsroom. To see archived news briefs dating back to January 2011, visit the News Archive.


How Has Neuromodulation Been Developed and Used?

Conventional medicine has typically had four modes of treating diseases or disorders: counseling or “talk therapy”; physical therapy involving manipulation and strengthening of muscles and range of motion; pharmaceuticals that act on a chemical level; and altering or augmenting tissue through surgery, injections, or filtering methods like dialysis. The growing field of neuromodulation is a new class of therapies that involves directly treating the nervous system itself, often through small implanted devices that target a specific area, to rebalance the activity of neural circuits and manage symptoms.

Progress has been spurred by advances in our understanding of the nervous system, as well as new technologies and clinical experience, enabling treatments to modify nerve cell activity in brain, spinal cord and periphery to restore function, minimize pain, and treat disease symptoms. Developed over the last 45 years, neuromodulation has grown rapidly into a family of therapies that applies stimulation or agents directly to the nervous system, often using small implanted medical devices that are powered in a similar fashion to a cardiac pacemaker. By delivering electrical or chemical stimulation, neuromodulation has increasingly been used to treat motor disorders such as Parkinson’s disease, refractory chronic pain ranging from neuropathy to cancer related pain to severe headaches, spasticity, epilepsy, and incontinence. It is also under study for conditions ranging from gastroparesis to medically refractory depression. Providers of such therapies include neurosurgeons, pain physician specialists and rehabilitation physicians. They may often work with other specialists such as neurologists, psychiatrists, psychologists, gastrointestinal or colorectal specialists, urologists, primary care physicians, and physical therapists to achieve best outcomes.

Learn More . . .

Medical Professionals can learn about various considerations concerning neuromodulation and clinic contacts. Once your preliminary questions have been answered, please use the Contact Us facility to find out more and to discuss specific objectives. Others may simply wish to join the INS and one of its related chapter societies, please use Membership Application.

Clinical trials that involve a wide range of emerging neuromodulation approaches are listed on our Resources and Research pages. Neuromodulator trials address symptom control through nerve stimulation in such condition categories as:


If you are not a medical professional
and you are searching for information about neuromodulation and how these types of treatment could benefit a specific condition such as treatment-resistant headache or other chronic pain syndromes, you may find the sections titled Therapies, About Neuromodulation or FAQs particularly helpful.

The International Neuromodulation Society (INS) is a non-profit group of clinicians, scientists and engineers dedicated to the scientific development and awareness of neuromodulation - the alteration of nerve activity through the delivery of electrical stimulation or chemical agents to targeted sites of the body. Founded in 1989 and based in San Francisco, CA, the INS educates and promotes the field through meetings, its peer-reviewed journal Neuromodulation: Technology at the Neural Interface, explanatory content, and chapter websites.

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Now indexed in MEDLINE!

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Neuromodulation: Technology at the Neural Interface
contains articles of the highest scientific caliber. The journal's sole purpose is to advance the basic and clinical science of the field of neuromodulation. In eight issues a year, it publishes scientific works, scientific reviews, and abstracts of papers accepted for review at national and international congresses.

Neuromodulation is now indexed in Index Medicus, MEDLINE and Pubmed!

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Last Updated on Wednesday, December 17, 2014 01:45 PM
 
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