Closed-Loop Stimulation

Closed-loop stimulation is a form of neuromodulation that provides therapeutic stimulation only when necessary. While it has been explored for conditions such as Parkinson’s disease, the most developed application of this emerging technology is in the treatment of refractory epilepsy – when seizures cannot be adequately controlled by medication alone. Much like a pacemaker stops abnormal heart rhythms, a closed-loop device aims to halt epileptic seizures by delivering stimulation when it detects the beginnings of seizure activity. NeuroPace, Inc. (Mountain View, CA), has developed a programmable responsive neurostimulation (RNS) brain implant that received pre-market approval from the FDA in November 2013. (1)


1. Anon. FDA Grants Premarket Approval (PMA) for the NeuroPace RNS System to treat Medically Refractory Epilepsy. NeuroPace: News. Accessed March 5, 2018.

red diamond Read more

. . . a closed-loop neuromodulation system only delivers stimulation when it detects the beginnings of seizure activity . . .

Reviewed Oct. 19, 2012
Chengyuan Wu, MD, MSBmE
Member, International Neuromodulation Society
Thomas Jefferson University Hospital, Department of Neurosurgery
Philadelphia, Pennsylvania, U.S.A.

Last Updated on Monday, March 05, 2018 01:26 PM